ID Q9A1N6_STRP1 Unreviewed; 220 AA.
AC Q9A1N6;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 123.
DE SubName: Full=Hexulose-6-phosphate synthase {ECO:0000313|EMBL:AAK33277.1};
GN OrderedLocusNames=SPy_0177 {ECO:0000313|EMBL:AAK33277.1};
OS Streptococcus pyogenes serotype M1.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=301447 {ECO:0000313|EMBL:AAK33277.1, ECO:0000313|Proteomes:UP000000750};
RN [1] {ECO:0000313|EMBL:AAK33277.1, ECO:0000313|Proteomes:UP000000750}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700294 / SF370 / Serotype M1
RC {ECO:0000313|Proteomes:UP000000750};
RX PubMed=11296296; DOI=10.1073/pnas.071559398;
RA Ferretti J.J., McShan W.M., Adjic D., Savic D., Savic G., Lyon K.,
RA Primeaux C., Sezate S.S., Surorov A.N., Kenton S., Lai H., Lin S., Qian Y.,
RA Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA Clifton S.W., Roe B.A., McLaughlin R.E.;
RT "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
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DR EMBL; AE004092; AAK33277.1; -; Genomic_DNA.
DR RefSeq; NP_268556.1; NC_002737.2.
DR AlphaFoldDB; Q9A1N6; -.
DR PaxDb; 1314-HKU360_00196; -.
DR KEGG; spy:SPy_0177; -.
DR PATRIC; fig|160490.10.peg.155; -.
DR HOGENOM; CLU_081825_0_0_9; -.
DR OMA; WEQAQEW; -.
DR Proteomes; UP000000750; Chromosome.
DR GO; GO:0004590; F:orotidine-5'-phosphate decarboxylase activity; IEA:InterPro.
DR GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR CDD; cd04726; KGPDC_HPS; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR041710; HPS/KGPDC.
DR InterPro; IPR001754; OMPdeCOase_dom.
DR InterPro; IPR011060; RibuloseP-bd_barrel.
DR PANTHER; PTHR35039; 3-KETO-L-GULONATE-6-PHOSPHATE DECARBOXYLASE SGBH-RELATED; 1.
DR PANTHER; PTHR35039:SF3; 3-KETO-L-GULONATE-6-PHOSPHATE DECARBOXYLASE SGBH-RELATED; 1.
DR Pfam; PF00215; OMPdecase; 1.
DR SMART; SM00934; OMPdecase; 1.
DR SUPFAM; SSF51366; Ribulose-phoshate binding barrel; 1.
PE 4: Predicted;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW Reference proteome {ECO:0000313|Proteomes:UP000000750}.
FT DOMAIN 6..211
FT /note="Orotidine 5'-phosphate decarboxylase"
FT /evidence="ECO:0000259|SMART:SM00934"
SQ SEQUENCE 220 AA; 23846 MW; 6D8204C1D39AA328 CRC64;
MTHIPNLQVA LDHSDLQGAV KAAVAVGHEV DVIEAGTVCL LQVGSELVEV LRSLFPEKII
VADTKCADAG GTVAKNNAKR GADWMTCICC ATIPTMEAAL KAIKEERGDR GEIQIELYGD
WTYEQAQLWL DAGISQAIYH QSRDALLAGE TWGEKDLNKV KTLIDMGFRV SVTGGLDVDT
LRLFEGVDVF TFIAGRGITE AEDPAAAARA FKDEIKRIWG
//
