ID Q9AK67_STRCO Unreviewed; 206 AA.
AC Q9AK67;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=Lysine N-acyltransferase MbtK {ECO:0000256|ARBA:ARBA00020586};
DE AltName: Full=Mycobactin synthase protein K {ECO:0000256|ARBA:ARBA00031122};
GN OrderedLocusNames=SCO4050 {ECO:0000313|EMBL:CAC32321.1};
GN ORFNames=2SCD60.16 {ECO:0000313|EMBL:CAC32321.1};
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226 {ECO:0000313|EMBL:CAC32321.1, ECO:0000313|Proteomes:UP000001973};
RN [1] {ECO:0000313|EMBL:CAC32321.1, ECO:0000313|Proteomes:UP000001973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145
RC {ECO:0000313|Proteomes:UP000001973};
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
CC -!- FUNCTION: Acyltransferase required for the direct transfer of
CC medium- to long-chain fatty acyl moieties from a carrier protein (MbtL)
CC on to the epsilon-amino group of lysine residue in the mycobactin core.
CC {ECO:0000256|ARBA:ARBA00003818}.
CC -!- PATHWAY: Siderophore biosynthesis; mycobactin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005102}.
CC -!- SIMILARITY: Belongs to the lysine N-acyltransferase MbtK family.
CC {ECO:0000256|ARBA:ARBA00009893}.
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DR EMBL; AL939118; CAC32321.1; -; Genomic_DNA.
DR RefSeq; NP_628232.1; NC_003888.3.
DR RefSeq; WP_003974913.1; NZ_VNID01000032.1.
DR AlphaFoldDB; Q9AK67; -.
DR STRING; 100226.gene:17761681; -.
DR PaxDb; 100226-SCO4050; -.
DR DNASU; 1099486; -.
DR PATRIC; fig|100226.15.peg.4112; -.
DR eggNOG; COG1670; Bacteria.
DR HOGENOM; CLU_039848_5_0_11; -.
DR InParanoid; Q9AK67; -.
DR OrthoDB; 5177616at2; -.
DR PhylomeDB; Q9AK67; -.
DR UniPathway; UPA00011; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0016410; F:N-acyltransferase activity; IBA:GO_Central.
DR GO; GO:0019290; P:siderophore biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.630.30; -; 1.
DR InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR InterPro; IPR019432; Acyltransferase_MbtK/IucB-like.
DR PANTHER; PTHR31438; LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED; 1.
DR PANTHER; PTHR31438:SF1; LYSINE N-ACYLTRANSFERASE C17G9.06C-RELATED; 1.
DR Pfam; PF13523; Acetyltransf_8; 1.
DR SMART; SM01006; AlcB; 1.
DR SUPFAM; SSF55729; Acyl-CoA N-acyltransferases (Nat); 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001973}.
FT DOMAIN 29..77
FT /note="Acyltransferase MbtK/IucB-like conserved"
FT /evidence="ECO:0000259|SMART:SM01006"
SQ SEQUENCE 206 AA; 22005 MW; A34CC4A6696870D8 CRC64;
MTDAPATPYA ARTPVHEQHL DGFGTVRVLP LDPAADAAVV HGWVGEERAA FWGMNDLTRD
QVAAVYAHMD TLDTHHAFLV VKDGEPAALL QTYDPAADRV SECYAAEPGD IGVHLLLAPA
GAEGTRPGWT AALSGALMAY VLLGLDRTRI VVDPDVANEK AIARFLKQGF TAGPAVVLPE
VDLPDVYLPE KKAQLAFLRR EVAFGA
//
