ID CXCR6_MACFA Reviewed; 343 AA.
AC Q9BDS6;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 24-JAN-2024, entry version 97.
DE RecName: Full=C-X-C chemokine receptor type 6;
DE Short=CXC-R6;
DE Short=CXCR-6;
DE AltName: Full=G-protein coupled receptor STRL33;
DE AltName: Full=G-protein coupled receptor bonzo;
DE AltName: CD_antigen=CD186;
GN Name=CXCR6; Synonyms=BONZO, STRL33;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11242524; DOI=10.1089/08892220150503744;
RA Wade-Evans A.M., Russell J., Jenkins A., Javan C.;
RT "Cloning and sequencing of cynomolgus macaque CCR3, GPR15, and STRL33:
RT potential coreceptors for HIV type 1, HIV type 2, and SIV.";
RL AIDS Res. Hum. Retroviruses 17:371-375(2001).
CC -!- FUNCTION: Receptor for the C-X-C chemokine CXCL16. Used as a coreceptor
CC by SIVs and by strains of HIV-2 and m-tropic HIV-1.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF291671; AAK25742.1; -; mRNA.
DR RefSeq; NP_001306326.1; NM_001319397.1.
DR AlphaFoldDB; Q9BDS6; -.
DR SMR; Q9BDS6; -.
DR STRING; 9541.ENSMFAP00000045217; -.
DR GlyCosmos; Q9BDS6; 1 site, No reported glycans.
DR eggNOG; ENOG502QSJQ; Eukaryota.
DR OrthoDB; 5322216at2759; -.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016494; F:C-X-C chemokine receptor activity; IEA:InterPro.
DR GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
DR GO; GO:0006935; P:chemotaxis; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:InterPro.
DR CDD; cd15173; 7tmA_CXCR6; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR002235; Chemokine_CXCR6.
DR InterPro; IPR000355; Chemokine_rcpt.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR10489:SF705; C-X-C CHEMOKINE RECEPTOR TYPE 6; 1.
DR PANTHER; PTHR10489; CELL ADHESION MOLECULE; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00657; CCCHEMOKINER.
DR PRINTS; PR01105; CXCCHMKINER6.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..343
FT /note="C-X-C chemokine receptor type 6"
FT /id="PRO_0000069366"
FT TOPO_DOM 1..33
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 34..60
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 61..69
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 70..90
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 91..104
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 105..126
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 127..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..188
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 189..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 233..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..276
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 277..294
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 295..343
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 17
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 103..181
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 343 AA; 39473 MW; 0961328F948E7784 CRC64;
MAEYDHYEDD GFLNSFNDSS QEEHQDFLQF RKVFLPCMYL VVFVCGLVGN SLVLVISIFY
HKLQSLTDVF LVNLPLADLV FVCTLPFWTY AGIHEWIFGQ VMCKTLLGVY TINFYTSMLI
LTCITVDRFI VVVKATKAYN QQAKRMTWGK VICLLIWVIS LLVSLPQIIY GNVFNLDKLI
CGYHDEEIST VVLATQMTLG FFLPLLAMIV CYSVIIKTLL HAGGFQKHRS LKIIFLVMAV
FLLTQTPFNL VKLIRSTRWE YYAMTSFHYT IIVTEAIAYL RACLNPVLYA FVSLKFRKNF
WKLVKDIGCL PYLGVSHQWK SSEDNSKTFS ASHNVEATSM FQL
//
