ID Q9BIB8_CAEEL Unreviewed; 896 AA.
AC Q9BIB8;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2002, sequence version 3.
DT 27-MAR-2024, entry version 148.
DE SubName: Full=Importin N-terminal domain-containing protein {ECO:0000313|EMBL:CCD69827.1};
GN Name=imb-1 {ECO:0000313|EMBL:CCD69827.1,
GN ECO:0000313|WormBase:F28B3.8};
GN ORFNames=CELE_F28B3.8 {ECO:0000313|EMBL:CCD69827.1}, F28B3.8
GN {ECO:0000313|WormBase:F28B3.8};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD69827.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD69827.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD69827.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the importin beta family. Importin beta-1
CC subfamily. {ECO:0000256|ARBA:ARBA00010907}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BX284601; CCD69827.1; -; Genomic_DNA.
DR RefSeq; NP_491477.2; NM_059076.5.
DR AlphaFoldDB; Q9BIB8; -.
DR SMR; Q9BIB8; -.
DR STRING; 6239.F28B3.8.1; -.
DR EPD; Q9BIB8; -.
DR PaxDb; 6239-F28B3-8; -.
DR PeptideAtlas; Q9BIB8; -.
DR EnsemblMetazoa; F28B3.8.1; F28B3.8.1; WBGene00002075.
DR EnsemblMetazoa; F28B3.8.2; F28B3.8.2; WBGene00002075.
DR GeneID; 172110; -.
DR KEGG; cel:CELE_F28B3.8; -.
DR UCSC; F28B3.8; c. elegans.
DR AGR; WB:WBGene00002075; -.
DR WormBase; F28B3.8; CE30523; WBGene00002075; imb-1.
DR eggNOG; KOG1241; Eukaryota.
DR GeneTree; ENSGT00550000074898; -.
DR HOGENOM; CLU_008296_1_0_1; -.
DR InParanoid; Q9BIB8; -.
DR OMA; QQYQERW; -.
DR OrthoDB; 124901at2759; -.
DR PhylomeDB; Q9BIB8; -.
DR Reactome; R-CEL-1655829; Regulation of cholesterol biosynthesis by SREBP (SREBF).
DR Reactome; R-CEL-6798695; Neutrophil degranulation.
DR Reactome; R-CEL-909733; Interferon alpha/beta signaling.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00002075; Expressed in embryo and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR GO; GO:0000003; P:reproduction; IMP:WormBase.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF1; IMPORTIN SUBUNIT BETA-1; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF03810; IBN_N; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:Q9BIB8,
KW ECO:0007829|PeptideAtlas:Q9BIB8};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 27..107
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
SQ SEQUENCE 896 AA; 98758 MW; C9C453822AFD44B6 CRC64;
MAEQAAEQML TVLEKTVSQN QNDQKQAMDY IAAACQQDFP VFVQCLSMIL RTQQCQSFVR
QAAGLQLKNV LCAKETETKN VYLQRWLQLT AEVREQVKQN VTGTLGTEPS RPSIAAQCVA
AIACAELPQN LWPNVINLLK SNVTESQSGE MLKESSLETL GYICQDIDPR VLETKANDVL
TAIIHGMRPE ESSANVRFAA TNALLNSLEF TNTNFSNEAE RNIIMQVVCE STSSSDQRVK
VAALQCLVRI MQLYYEHMLS YMGSALFQIT LSAMKSQEPE VAMQGMEFWS TVAEEEFDLY
MTYEDEVERG APNPKCASLR FMEQAASHVC PVLLEAMAHH DDGDDDDDWT PAKAAGVCLM
LAAQCVRDDI VNHVIPFFKH FQNPDWKYKE AAIMAFGSIL DGPDPKKLLP MAQEALPAIV
AAMCDKNVNV RDTAAWSLGR VIDTCSELAN NAELLQSVLP VLSNGLHQEP RVANNVCWAL
VSLVKACYES AVANGTDGSG QPDTFALSSV FDPMVGELIK ITDRVDGNQS NLRITAYEAL
MELIKHSPKD CYSAVRNTTV VILKKLESLL QMESQATSEA DKAQVRDLQA MLCATLQSVT
RKMQPADIPA VGEHIMNGLY QIMNRAAATR SNAVMEEALL AVACLAEHLG KGFLSYMNVL
KPYLLEGLSN TDETQVCAAA VGLVTDLSRA LEAEIMPFMD ELIQKLILCL QSPRLDRNVK
VVIIGTFADI AMAIEAHFER YVGSVVPILN NAQNAAVVTD PNDDDQVDYV DRLREACLNS
YTGIIQGLKA IPDTTAARNM INVFVEPIVQ LITRISSMEP VPPSEALIAT TAGIIGDLVQ
LYEGDIIRFF LTDNVTQMLQ KGRKSKVSKT KSMANWATKE IKKHTNNGAA TFNFNR
//
