ID Q9BKR5_CAEEL Unreviewed; 921 AA.
AC Q9BKR5;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 2.
DT 27-MAR-2024, entry version 126.
DE SubName: Full=Nuclear export mediator factor NEMF {ECO:0000313|EMBL:CCD73050.1};
GN ORFNames=CELE_Y82E9BR.18 {ECO:0000313|EMBL:CCD73050.1}, Y82E9BR.18
GN {ECO:0000313|EMBL:CCD73050.1, ECO:0000313|WormBase:Y82E9BR.18};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CCD73050.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CCD73050.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD73050.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the NEMF family.
CC {ECO:0000256|ARBA:ARBA00008318}.
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DR EMBL; BX284603; CCD73050.1; -; Genomic_DNA.
DR RefSeq; NP_497411.2; NM_065010.5.
DR AlphaFoldDB; Q9BKR5; -.
DR SMR; Q9BKR5; -.
DR STRING; 6239.Y82E9BR.18.1; -.
DR EPD; Q9BKR5; -.
DR PaxDb; 6239-Y82E9BR-18; -.
DR PeptideAtlas; Q9BKR5; -.
DR EnsemblMetazoa; Y82E9BR.18.1; Y82E9BR.18.1; WBGene00022350.
DR EnsemblMetazoa; Y82E9BR.18.2; Y82E9BR.18.2; WBGene00022350.
DR GeneID; 175303; -.
DR KEGG; cel:CELE_Y82E9BR.18; -.
DR UCSC; Y82E9BR.18; c. elegans.
DR AGR; WB:WBGene00022350; -.
DR WormBase; Y82E9BR.18; CE33002; WBGene00022350; -.
DR eggNOG; KOG2030; Eukaryota.
DR GeneTree; ENSGT00390000018516; -.
DR HOGENOM; CLU_003612_1_1_1; -.
DR InParanoid; Q9BKR5; -.
DR OMA; MFLEFFA; -.
DR OrthoDB; 129892at2759; -.
DR PhylomeDB; Q9BKR5; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00022350; Expressed in germ line (C elegans) and 4 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:1990112; C:RQC complex; IBA:GO_Central.
DR GO; GO:0043023; F:ribosomal large subunit binding; IBA:GO_Central.
DR GO; GO:0000049; F:tRNA binding; IBA:GO_Central.
DR GO; GO:0072344; P:rescue of stalled ribosome; IBA:GO_Central.
DR GO; GO:1990116; P:ribosome-associated ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR Gene3D; 2.30.310.10; ibrinogen binding protein from staphylococcus aureus domain; 1.
DR InterPro; IPR021846; NFACT-C.
DR InterPro; IPR008532; NFACT_RNA-bd.
DR NCBIfam; NF041120; RqcH_arch; 1.
DR PANTHER; PTHR15239; NUCLEAR EXPORT MEDIATOR FACTOR NEMF; 1.
DR PANTHER; PTHR15239:SF6; RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF; 1.
DR Pfam; PF11923; NFACT-C; 1.
DR Pfam; PF05670; NFACT-R_1; 1.
DR Pfam; PF05833; NFACT_N; 1.
PE 1: Evidence at protein level;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Proteomics identification {ECO:0007829|EPD:Q9BKR5,
KW ECO:0007829|PeptideAtlas:Q9BKR5};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940}.
FT DOMAIN 493..604
FT /note="NFACT RNA-binding"
FT /evidence="ECO:0000259|Pfam:PF05670"
FT DOMAIN 824..892
FT /note="NFACT protein C-terminal"
FT /evidence="ECO:0000259|Pfam:PF11923"
FT REGION 633..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 305..342
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 448..475
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 697..714
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..807
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 921 AA; 105001 MW; 9906787CF1244A4E CRC64;
MKNRFTLVDV IAATTELKKL EGMRVNNVYD IDNKTYLIKL SRTDEKAVIL FESGVRLHQT
FHDWPKSQTP SSFSMKLRKH INQKRLTSIR VVGFDRLVEL TFGTEDRENR LYVELYDRGN
VVLTDQELTI LNILRVRTDK DTSVRWAVRE KFTFSDDENS AAKTGEKLEI SDVKLAISGI
PDGKEEQFGR ILAQITKCGN PVTKEILARC QVKWDTKIKN SSEISEIFDG NLHKFEEIQK
ATEDVWDTVL HKPLGFISYS EVLSPISTPI QIYQDFNPIS MEFTAKLSKE LSSFCEAVDE
FYSRIETQKQ EQKAVNMEKQ ALKKLENVEK DQKDRIEALQ LTQSQREQMA NRIILNTELV
EKALLLIRSA LANQFSWQTI EEMRKTAAGN GDPVAKSIDS FKFENNEFMM SLADPYDDEA
EVLKVPIDIS LNASKNAQRH FVDKKSAAEK VKKTVASSEK AIKNAQEKAK STLEQVKIVV
EVKKSRKSMW FEKFRWFISS EGFIVVAGRD AQQNELLVKK YLRPNDIYMH ADVRGASSVV
IRNKSFDAEI PPKTLTEAAQ MAVCYSNAWE ATVTASAWWV HPDQVSRTAP TGEYLPSGSF
MIRGKKNFMP PSQLVMGLGI LFRMDEESIE RHVALEKSKA EEKSEEDGEK MEDSPKKTAK
IPENPAENDE FPDIEVKIAR PSGEEAEEMT LIEVGPKNPV KNSQNAQKLP KNAEKTTQLY
LEEKLKEQLG GPSAKTQKRR QRKEKLAKMK YKDQTDDDLE LHKELLKPQG KIVEKVEERP
VERPEKSEKP VKIEEFKPKI QEKRENPDEE AEEPEEDDKE ANLEELSILT TLTAQPLDED
TLLFAVPVVA PYSALSTYKY RVKITPGIGK RGKATKSAIE LFTRQRTDRQ AALIKSLLSD
DSASRNLPTK VRISAPQLHA K
//
