ID MFS55_MYCLE Reviewed; 509 AA.
AC Q9CCP7;
DT 11-NOV-2015, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 117.
DE RecName: Full=Probable triacylglyceride transporter ML0556 {ECO:0000250|UniProtKB:P9WJY3};
DE AltName: Full=MFS-type drug efflux transporter P55;
GN OrderedLocusNames=ML0556;
OS Mycobacterium leprae (strain TN).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium.
OX NCBI_TaxID=272631;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TN;
RX PubMed=11234002; DOI=10.1038/35059006;
RA Cole S.T., Eiglmeier K., Parkhill J., James K.D., Thomson N.R.,
RA Wheeler P.R., Honore N., Garnier T., Churcher C.M., Harris D.E.,
RA Mungall K.L., Basham D., Brown D., Chillingworth T., Connor R.,
RA Davies R.M., Devlin K., Duthoy S., Feltwell T., Fraser A., Hamlin N.,
RA Holroyd S., Hornsby T., Jagels K., Lacroix C., Maclean J., Moule S.,
RA Murphy L.D., Oliver K., Quail M.A., Rajandream M.A., Rutherford K.M.,
RA Rutter S., Seeger K., Simon S., Simmonds M., Skelton J., Squares R.,
RA Squares S., Stevens K., Taylor K., Whitehead S., Woodward J.R.,
RA Barrell B.G.;
RT "Massive gene decay in the leprosy bacillus.";
RL Nature 409:1007-1011(2001).
CC -!- FUNCTION: In association with lipoprotein LprG probably transports
CC triacylglycerides (TAG) across the inner cell membrane into the
CC periplasm; TAG probably regulates lipid metabolism and growth
CC regulation. May be an efflux transporter and involved in maintaining
CC correct cell wall permeability. Probably required with LprG for normal
CC surface localization of lipoarabinomannan (LAM).
CC {ECO:0000250|UniProtKB:P9WJY3}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255}; Multi-pass
CC membrane protein {ECO:0000255}.
CC -!- MISCELLANEOUS: Bacterial LAM blocks host cell phagosome-lysosome fusion
CC and is one way in which Mycobacteria evade the host immune system.
CC {ECO:0000305}.
CC -!- MISCELLANEOUS: Triacylglycerides accumulate in lipid droplets in the
CC cytoplasm of M.leprae, and are used as an energy source during
CC starvation. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC {ECO:0000305}.
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DR EMBL; AL583918; CAC30064.1; -; Genomic_DNA.
DR PIR; D86978; D86978.
DR RefSeq; NP_301470.1; NC_002677.1.
DR RefSeq; WP_010907794.1; NC_002677.1.
DR AlphaFoldDB; Q9CCP7; -.
DR SMR; Q9CCP7; -.
DR STRING; 272631.gene:17574377; -.
DR KEGG; mle:ML0556; -.
DR PATRIC; fig|272631.5.peg.967; -.
DR Leproma; ML0556; -.
DR eggNOG; COG0477; Bacteria.
DR HOGENOM; CLU_000960_2_5_11; -.
DR OrthoDB; 3453194at2; -.
DR Proteomes; UP000000806; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17321; MFS_MMR_MDR_like; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 1.20.1720.10; Multidrug resistance protein D; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR PANTHER; PTHR23501; MAJOR FACILITATOR SUPERFAMILY; 1.
DR PANTHER; PTHR23501:SF202; TRIACYLGLYCERIDE TRANSPORTER RV1410C-RELATED; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..509
FT /note="Probable triacylglyceride transporter ML0556"
FT /id="PRO_0000434647"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 112..132
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 232..252
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..329
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 339..359
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 381..403
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 410..430
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 477..497
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 509 AA; 53712 MW; 2EC18FF618051644 CRC64;
MSTRAGRRVA ISAGSLAVLL GALDTYVVVT IMRDIMHDVG IPVNQMQRIT WIVTMYLLGY
IAAMPLLSRA SDRFGRKLLL QVSLAGFAIG SVMTALAGQF GDFHMLIAGR TIQGVASGAL
LPITLALGAD LWAQRNRAGV LGGIGAAQEL GSVLGPLYGI FIVWLFSDWR YVFWINIPLT
AIAMLMIQVS LSAHDRGDEL EKVDVVGGVL LAIALGLVVI GLYNPQPDSK QVLPSYGVPV
LVGGIVATVA FAVWERCART RLIDPAGVHI RPFLSALGAS VAAGAALMVT LVNVELFGQG
VLGMDQTQAA GLLVWFLIAL PIGAVLGGWG ATKAGDRTMT FVGLLITAGG YWLISHWPVD
LLNYRRSIFG LFSVPTMYAD LLVAGLGLGL VIGPLSSATL RVVPTAQHGI ASAAVVVARM
TGMLIGVAAL TAWGLYRFNQ ILAGLSTAVP PDATLIERAA AVADQAKRAY TMMYSDIFMI
TAIVCVIGAL LGLLISSRKE HASEPKVPE
//
