ID Q9CDN4_LACLA Unreviewed; 302 AA.
AC Q9CDN4;
DT 01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 119.
DE SubName: Full=6-phosphogluconate dehydrogenase {ECO:0000313|EMBL:AAK06283.1};
DE EC=1.1.1.44 {ECO:0000313|EMBL:AAK06283.1};
GN Name=gntZ {ECO:0000313|EMBL:AAK06283.1};
GN ORFNames=L53699 {ECO:0000313|EMBL:AAK06283.1};
OS Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus.
OX NCBI_TaxID=272623 {ECO:0000313|EMBL:AAK06283.1, ECO:0000313|Proteomes:UP000002196};
RN [1] {ECO:0000313|EMBL:AAK06283.1, ECO:0000313|Proteomes:UP000002196}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IL1403 {ECO:0000313|EMBL:AAK06283.1,
RC ECO:0000313|Proteomes:UP000002196};
RX PubMed=11337471; DOI=10.1101/gr.GR-1697R;
RA Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J.,
RA Ehrlich S.D., Sorokin A.;
RT "The complete genome sequence of the lactic acid bacterium Lactococcus
RT lactis ssp. lactis IL1403.";
RL Genome Res. 11:731-753(2001).
CC -!- SIMILARITY: Belongs to the 6-phosphogluconate dehydrogenase family.
CC {ECO:0000256|ARBA:ARBA00008419}.
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DR EMBL; AE005176; AAK06283.1; -; Genomic_DNA.
DR PIR; A86898; A86898.
DR RefSeq; NP_268342.1; NC_002662.1.
DR AlphaFoldDB; Q9CDN4; -.
DR PaxDb; 272623-L53699; -.
DR EnsemblBacteria; AAK06283; AAK06283; L53699.
DR KEGG; lla:L53699; -.
DR PATRIC; fig|272623.7.peg.2347; -.
DR eggNOG; COG1023; Bacteria.
DR HOGENOM; CLU_024540_0_0_9; -.
DR OrthoDB; 9804542at2; -.
DR Proteomes; UP000002196; Chromosome.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:UniProtKB-EC.
DR GO; GO:0019521; P:D-gluconate metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR GO; GO:0006098; P:pentose-phosphate shunt; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR004849; 6DGDH_YqeC.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006114; 6PGDH_C.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006183; Pgluconate_DH.
DR NCBIfam; TIGR00872; gnd_rel; 1.
DR PANTHER; PTHR11811; 6-PHOSPHOGLUCONATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11811:SF67; 6-PHOSPHOGLUCONATE DEHYDROGENASE YQEC-RELATED; 1.
DR Pfam; PF00393; 6PGD; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PRINTS; PR00076; 6PGDHDRGNASE.
DR SMART; SM01350; 6PGD; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Gluconate utilization {ECO:0000256|ARBA:ARBA00023064};
KW Oxidoreductase {ECO:0000313|EMBL:AAK06283.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002196}.
FT DOMAIN 171..300
FT /note="6-phosphogluconate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|SMART:SM01350"
SQ SEQUENCE 302 AA; 33185 MW; 67A4EADAD66E3608 CRC64;
MMKFGMIGLG KMGMNLVKNA VDHEIEVVAY DLNTKAVEEA KDYSDKITAV STIENLLTEL
PASKIVWLML PAGTPTNSTI EMLSEKLSAG DILIDGGNSN YKDNLEQNKL LTEKGIKFFD
VGTSGGMAGA RQGGNFMIGG DDEKSWTIIE PIFKAISMEE GYLYTGKLGS GHYLKMIHNG
IEYGMMQAIA EGFEILEESP FDYDYEAVAK LWNHGSVIRS WLMELAQEQF SKDPKLDQII
GHVQSSGEGK WTVEESLDLG VPAPVIALSL MMRQRSLQED TMTGKVVAAL RNGFGGHDVE
QK
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