GenomeNet

Database: UniProt
Entry: Q9CYA0
LinkDB: Q9CYA0
Original site: Q9CYA0 
ID   CREL2_MOUSE             Reviewed;         350 AA.
AC   Q9CYA0;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   13-FEB-2019, entry version 130.
DE   RecName: Full=Cysteine-rich with EGF-like domain protein 2;
DE   Flags: Precursor;
GN   Name=Creld2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Embryo, and Lung;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=FVB/N; TISSUE=Colon;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney, Liver, Lung, Pancreas, Spleen, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: May regulate transport of alpha4-beta2 neuronal
CC       acetylcholine receptor. {ECO:0000250}.
CC   -!- SUBUNIT: May interact with CHRNA4. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted. Endoplasmic reticulum
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRELD family. {ECO:0000305}.
DR   EMBL; AK017880; BAB30986.1; -; mRNA.
DR   EMBL; AK165884; BAE38436.1; -; mRNA.
DR   EMBL; BC047370; AAH47370.1; -; mRNA.
DR   CCDS; CCDS27733.1; -.
DR   RefSeq; NP_083996.1; NM_029720.2.
DR   UniGene; Mm.292567; -.
DR   ProteinModelPortal; Q9CYA0; -.
DR   SMR; Q9CYA0; -.
DR   IntAct; Q9CYA0; 3.
DR   MINT; Q9CYA0; -.
DR   STRING; 10090.ENSMUSP00000024042; -.
DR   iPTMnet; Q9CYA0; -.
DR   PhosphoSitePlus; Q9CYA0; -.
DR   EPD; Q9CYA0; -.
DR   jPOST; Q9CYA0; -.
DR   MaxQB; Q9CYA0; -.
DR   PaxDb; Q9CYA0; -.
DR   PeptideAtlas; Q9CYA0; -.
DR   PRIDE; Q9CYA0; -.
DR   Ensembl; ENSMUST00000024042; ENSMUSP00000024042; ENSMUSG00000023272.
DR   GeneID; 76737; -.
DR   KEGG; mmu:76737; -.
DR   UCSC; uc007xep.1; mouse.
DR   CTD; 79174; -.
DR   MGI; MGI:1923987; Creld2.
DR   eggNOG; KOG4260; Eukaryota.
DR   eggNOG; ENOG41107X2; LUCA.
DR   GeneTree; ENSGT00940000160071; -.
DR   HOGENOM; HOG000004778; -.
DR   HOVERGEN; HBG081344; -.
DR   InParanoid; Q9CYA0; -.
DR   OMA; CVGCTGK; -.
DR   OrthoDB; 883628at2759; -.
DR   PhylomeDB; Q9CYA0; -.
DR   TreeFam; TF316507; -.
DR   ChiTaRS; Creld2; mouse.
DR   PRO; PR:Q9CYA0; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   Bgee; ENSMUSG00000023272; Expressed in 291 organ(s), highest expression level in prostate gland.
DR   Genevisible; Q9CYA0; MM.
DR   GO; GO:0005783; C:endoplasmic reticulum; IDA:MGI.
DR   GO; GO:0005615; C:extracellular space; IDA:MGI.
DR   GO; GO:0005794; C:Golgi apparatus; IDA:MGI.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005201; F:extracellular matrix structural constituent; HDA:BHF-UCL.
DR   CDD; cd00064; FU; 2.
DR   InterPro; IPR021852; DUF3456.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR006212; Furin_repeat.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR002049; Laminin_EGF.
DR   Pfam; PF11938; DUF3456; 1.
DR   Pfam; PF07645; EGF_CA; 2.
DR   SMART; SM00181; EGF; 4.
DR   SMART; SM00179; EGF_CA; 2.
DR   SMART; SM00261; FU; 2.
DR   SUPFAM; SSF57184; SSF57184; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 2.
PE   1: Evidence at protein level;
KW   Calcium; Complete proteome; Disulfide bond; EGF-like domain;
KW   Endoplasmic reticulum; Glycoprotein; Reference proteome; Repeat;
KW   Secreted; Signal.
FT   SIGNAL        1     22       {ECO:0000255}.
FT   CHAIN        23    350       Cysteine-rich with EGF-like domain
FT                                protein 2.
FT                                /FTId=PRO_0000256246.
FT   DOMAIN      134    176       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT      191    238       FU 1.
FT   REPEAT      251    298       FU 2.
FT   DOMAIN      288    329       EGF-like 2; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   CARBOHYD    249    249       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    138    152       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    146    164       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    166    175       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    292    306       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    299    315       {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   DISULFID    317    328       {ECO:0000255|PROSITE-ProRule:PRU00076}.
SQ   SEQUENCE   350 AA;  38220 MW;  781D7389B1944231 CRC64;
     MHLLLAAAFG LLLLLPPPGA VASRKPTMCQ RCRTLVDKFN QGMANTARKN FGGGNTAWEE
     KTLSKYEFSE IRLLEIMEGL CDSSDFECNQ LLEQQEEQLE AWWQTLKKEH PNLFEWFCVH
     TLKACCLPGT YGPDCQECQG GSERPCSGNG YCSGDGSRQG DGSCQCHTGY KGPLCIDCTD
     GFFSLQRNET HSICSACDES CKTCSGPSNK DCIQCEVGWA RVEDACVDVD ECAAETSPCS
     DGQYCENVNG SYTCEDCDST CVGCTGKGPA NCKECIAGYT KESGQCTDID ECSLEEKACK
     RKNENCYNVP GSFVCVCPEG FEETEDACVQ TAEGKVTEEN PTQPPSREDL
//
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