ID EFC11_MOUSE Reviewed; 162 AA.
AC Q9D0E5; Q9D041;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 27-MAR-2024, entry version 141.
DE RecName: Full=EF-hand calcium-binding domain-containing protein 11;
GN Name=Efcab11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9D0E5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9D0E5-2; Sequence=VSP_025103;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK011507; BAB27665.1; -; mRNA.
DR EMBL; AK011836; BAB27869.1; -; mRNA.
DR EMBL; AK035051; BAC28925.1; -; mRNA.
DR EMBL; BC049109; AAH49109.1; -; mRNA.
DR CCDS; CCDS26104.1; -. [Q9D0E5-1]
DR RefSeq; NP_084448.1; NM_030172.2. [Q9D0E5-1]
DR RefSeq; XP_006516446.1; XM_006516383.3.
DR RefSeq; XP_011242518.1; XM_011244216.2.
DR AlphaFoldDB; Q9D0E5; -.
DR SMR; Q9D0E5; -.
DR STRING; 10090.ENSMUSP00000044808; -.
DR iPTMnet; Q9D0E5; -.
DR PhosphoSitePlus; Q9D0E5; -.
DR PaxDb; 10090-ENSMUSP00000044808; -.
DR ProteomicsDB; 277691; -. [Q9D0E5-1]
DR Antibodypedia; 65215; 18 antibodies from 11 providers.
DR Ensembl; ENSMUST00000046485.5; ENSMUSP00000044808.4; ENSMUSG00000021176.7. [Q9D0E5-1]
DR Ensembl; ENSMUST00000223114.2; ENSMUSP00000152734.2; ENSMUSG00000021176.7. [Q9D0E5-1]
DR GeneID; 78767; -.
DR KEGG; mmu:78767; -.
DR UCSC; uc007osb.1; mouse. [Q9D0E5-2]
DR UCSC; uc007osc.1; mouse. [Q9D0E5-1]
DR AGR; MGI:1926017; -.
DR CTD; 90141; -.
DR MGI; MGI:1926017; Efcab11.
DR VEuPathDB; HostDB:ENSMUSG00000021176; -.
DR eggNOG; KOG0027; Eukaryota.
DR GeneTree; ENSGT00390000004917; -.
DR HOGENOM; CLU_114999_0_0_1; -.
DR InParanoid; Q9D0E5; -.
DR OMA; YAMKHGQ; -.
DR OrthoDB; 3558415at2759; -.
DR PhylomeDB; Q9D0E5; -.
DR TreeFam; TF329255; -.
DR BioGRID-ORCS; 78767; 0 hits in 76 CRISPR screens.
DR ChiTaRS; Egfem1; mouse.
DR PRO; PR:Q9D0E5; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q9D0E5; Protein.
DR Bgee; ENSMUSG00000021176; Expressed in spermatocyte and 109 other cell types or tissues.
DR ExpressionAtlas; Q9D0E5; baseline and differential.
DR Genevisible; Q9D0E5; MM.
DR GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR PANTHER; PTHR23050; CALCIUM BINDING PROTEIN; 1.
DR PANTHER; PTHR23050:SF354; EF-HAND CALCIUM-BINDING DOMAIN-CONTAINING PROTEIN 11; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF13833; EF-hand_8; 1.
DR SMART; SM00054; EFh; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Calcium; Metal-binding; Reference proteome; Repeat.
FT CHAIN 1..162
FT /note="EF-hand calcium-binding domain-containing protein
FT 11"
FT /id="PRO_0000286581"
FT DOMAIN 18..53
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 91..126
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 127..162
FT /note="EF-hand 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 140
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 142
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 144
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 146
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT BINDING 151
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT VAR_SEQ 137..162
FT /note="READQDSDGHVSFRDFEYAMNHGQSK -> SSCF (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025103"
SQ SEQUENCE 162 AA; 18470 MW; 234FA3067585B325 CRC64;
MFLSEAGARP RAGEASASER RKWVKVFKAC DEDNKGYLSR EDFKVAIVML FGYKPSKIEA
DAVMSSVNPN TSGVSLEGFL SAVKRKKEAR LYRNEIRQIF TAFDVHYRGF LTLEDFKRAF
SRVAPKLPAR TVLEVFREAD QDSDGHVSFR DFEYAMNHGQ SK
//
