GenomeNet

Database: UniProt
Entry: Q9D226
LinkDB: Q9D226
Original site: Q9D226 
ID   KRA53_MOUSE             Reviewed;         196 AA.
AC   Q9D226;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   10-MAY-2017, entry version 73.
DE   RecName: Full=Keratin-associated protein 5-3 {ECO:0000250|UniProtKB:Q6L8H2};
GN   Name=Krtap5-3 {ECO:0000312|MGI:MGI:1924465};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000312|EMBL:BAB32180.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB32180.1};
RC   TISSUE=Neonatal skin {ECO:0000312|EMBL:BAB32180.1};
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments
CC       are embedded in an interfilamentous matrix, consisting of hair
CC       keratin-associated protein (KRTAP), which are essential for the
CC       formation of a rigid and resistant hair shaft through their
CC       extensive disulfide bond cross-linking with abundant cysteine
CC       residues of hair keratins. The matrix proteins include the high-
CC       sulfur and high-glycine-tyrosine keratins. {ECO:0000305}.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 5 family.
CC       {ECO:0000250|UniProtKB:Q6L8H2}.
DR   EMBL; AK020699; BAB32180.1; -; mRNA.
DR   UniGene; Mm.462993; -.
DR   ProteinModelPortal; Q9D226; -.
DR   PaxDb; Q9D226; -.
DR   PRIDE; Q9D226; -.
DR   MGI; MGI:1924465; Krtap5-3.
DR   PRO; PR:Q9D226; -.
DR   Proteomes; UP000000589; Unplaced.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Complete proteome; Keratin; Reference proteome; Repeat.
FT   CHAIN         1    196       Keratin-associated protein 5-3.
FT                                /FTId=PRO_0000361659.
FT   REPEAT       14     17       1.
FT   REPEAT       20     23       2.
FT   REGION       14     23       2 X 4 AA repeats of C-C-X-P.
FT   COMPBIAS      3    133       Cys-rich. {ECO:0000255}.
FT   COMPBIAS    146    174       Leu-rich. {ECO:0000255}.
SQ   SEQUENCE   196 AA;  17777 MW;  2136738FD496D815 CRC64;
     MSCCGCCGGC GSSCCKPVCC CVPVCSCSSC GGCKGGCSSC GGCGSCGGCK GGCGSCGGCG
     SCGGCKGGCG SCGGCGSCGG CKGGCGSCGG CGSCGGCKGG CGSCGGCGSC GGCKGGCSSC
     GGCGSCGAAS PSCVSPAAAS PAVQALLLPV QLLQALLLPA QLLLVQLLLS LLLLHDCGSS
     CCPMSCSLPI YCQREI
//
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