ID Q9DGK8_XENLA Unreviewed; 147 AA.
AC Q9DGK8;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Atrial natriuretic factor {ECO:0000313|EMBL:AAG01000.1, ECO:0000313|RefSeq:NP_001080999.1};
GN Name=nppa.L {ECO:0000313|RefSeq:NP_001080999.1,
GN ECO:0000313|Xenbase:XB-GENE-865042};
GN Synonyms=anf {ECO:0000313|RefSeq:NP_001080999.1}, anf-A
GN {ECO:0000313|RefSeq:NP_001080999.1}, anp
GN {ECO:0000313|RefSeq:NP_001080999.1}, nppa
GN {ECO:0000313|Xenbase:XB-GENE-865042};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAG01000.1};
RN [1] {ECO:0000313|EMBL:AAG01000.1}
RP NUCLEOTIDE SEQUENCE.
RA Small E.M., Krieg P.A.;
RT "Expression of atrial natriuretic factor (ANF) during Xenopus cardiac
RT development.";
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|RefSeq:NP_001080999.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=14557693;
RA Sharma S., Razeghi P., Shakir A., Keneson BJ 2.n.d., Clubb F.,
RA Taegtmeyer H.;
RT "Regional heterogeneity in gene expression profiles: a transcript analysis
RT in human and rat heart.";
RL Cardiology 100:73-79(2003).
RN [3] {ECO:0000313|RefSeq:NP_001080999.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613,
CC ECO:0000256|RuleBase:RU003686}.
CC -!- SIMILARITY: Belongs to the natriuretic peptide family.
CC {ECO:0000256|RuleBase:RU003686}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF287050; AAG01000.1; -; mRNA.
DR RefSeq; NP_001080999.1; NM_001087530.1.
DR STRING; 8355.Q9DGK8; -.
DR PaxDb; 8355-Q9DGK8; -.
DR GeneID; 394320; -.
DR KEGG; xla:394320; -.
DR AGR; Xenbase:XB-GENE-865042; -.
DR CTD; 394320; -.
DR Xenbase; XB-GENE-865042; nppa.L.
DR OMA; CQHTLVS; -.
DR OrthoDB; 4309387at2759; -.
DR Proteomes; UP000186698; Chromosome 7L.
DR Bgee; 394320; Expressed in heart and 6 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR GO; GO:0097746; P:blood vessel diameter maintenance; IEA:UniProtKB-KW.
DR InterPro; IPR000663; Natr_peptide.
DR InterPro; IPR030480; Natr_peptide_CS.
DR InterPro; IPR002407; Natriuretic_peptide_atrial.
DR PANTHER; PTHR14066; ATRIAL NATRIURETIC FACTOR PRECURSOR; 1.
DR PANTHER; PTHR14066:SF2; NATRIURETIC PEPTIDES A; 1.
DR Pfam; PF00212; ANP; 1.
DR PRINTS; PR00711; ANATPEPTIDE.
DR PRINTS; PR00710; NATPEPTIDES.
DR SMART; SM00183; NAT_PEP; 1.
DR PROSITE; PS00263; NATRIURETIC_PEPTIDE; 1.
PE 2: Evidence at transcript level;
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|SAM:SignalP, ECO:0000313|RefSeq:NP_001080999.1};
KW Vasoactive {ECO:0000256|RuleBase:RU003686}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..147
FT /evidence="ECO:0000256|SAM:SignalP,
FT ECO:0000313|RefSeq:NP_001080999.1"
FT /id="PRO_5033206592"
SQ SEQUENCE 147 AA; 16350 MW; 99B6C266778830FD CRC64;
MQTSFVGYFT LIFFLLSLMK AKGSPAYSSV LSSDLTDLKN ILERLEDRVT AEEPMAPSQD
LFAQNYDAAD SSNSAPSWTG EAIRPQSDII YNKGSSWETP DKLSRLKSKL RELLNSPRSL
RRSSDCFGGR IDRIGAQSGM GCNSHRF
//
