GenomeNet

Database: UniProt
Entry: Q9FG08
LinkDB: Q9FG08
Original site: Q9FG08 
ID   ATXR4_ARATH             Reviewed;         325 AA.
AC   Q9FG08;
DT   02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 2.
DT   16-JAN-2019, entry version 97.
DE   RecName: Full=Histone-lysine N-methyltransferase ATXR4;
DE            EC=2.1.1.43;
DE   AltName: Full=Protein SET DOMAIN GROUP 38;
DE   AltName: Full=Trithorax-related protein 4;
DE            Short=TRX-related protein 4;
DE   Flags: Precursor;
GN   Name=ATXR4; Synonyms=SDG38, SET38; OrderedLocusNames=At5g06620;
GN   ORFNames=F15M7.15;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RA   Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL   Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana
RT   reference genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NOMENCLATURE.
RX   PubMed=11691919; DOI=10.1093/nar/29.21.4319;
RA   Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K.,
RA   Assalkhou R., Schulz I., Reuter G., Aalen R.B.;
RT   "The Arabidopsis thaliana genome contains at least 29 active genes
RT   encoding SET domain proteins that can be assigned to four
RT   evolutionarily conserved classes.";
RL   Nucleic Acids Res. 29:4319-4333(2001).
CC   -!- FUNCTION: Histone methyltransferase. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-lysyl-[histone] + S-adenosyl-L-methionine = H(+) +
CC         N(6)-methyl-L-lysyl-[histone] + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:10024, Rhea:RHEA-COMP:9845, Rhea:RHEA-COMP:9846,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:61929; EC=2.1.1.43;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the class V-like SAM-binding
CC       methyltransferase superfamily. Histone-lysine methyltransferase
CC       family. TRX/MLL subfamily. {ECO:0000255|PROSITE-ProRule:PRU00190}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB11411.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; AP002543; BAB11411.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED91043.1; -; Genomic_DNA.
DR   RefSeq; NP_196280.2; NM_120745.3.
DR   UniGene; At.32832; -.
DR   ProteinModelPortal; Q9FG08; -.
DR   BioGrid; 15829; 1.
DR   STRING; 3702.AT5G06620.1; -.
DR   PaxDb; Q9FG08; -.
DR   PRIDE; Q9FG08; -.
DR   EnsemblPlants; AT5G06620.1; AT5G06620.1; AT5G06620.
DR   GeneID; 830550; -.
DR   Gramene; AT5G06620.1; AT5G06620.1; AT5G06620.
DR   KEGG; ath:AT5G06620; -.
DR   Araport; AT5G06620; -.
DR   TAIR; locus:2144138; AT5G06620.
DR   eggNOG; KOG2084; Eukaryota.
DR   eggNOG; COG2940; LUCA.
DR   HOGENOM; HOG000030561; -.
DR   InParanoid; Q9FG08; -.
DR   KO; K11426; -.
DR   OMA; HIIWIEN; -.
DR   OrthoDB; 1001347at2759; -.
DR   PhylomeDB; Q9FG08; -.
DR   PRO; PR:Q9FG08; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FG08; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0018024; F:histone-lysine N-methyltransferase activity; IEA:UniProtKB-EC.
DR   InterPro; IPR001214; SET_dom.
DR   Pfam; PF00856; SET; 1.
DR   SMART; SM00317; SET; 1.
DR   PROSITE; PS50280; SET; 1.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Complete proteome; Methyltransferase; Nucleus;
KW   Reference proteome; S-adenosyl-L-methionine; Signal; Transferase.
FT   SIGNAL        1     30       {ECO:0000255}.
FT   CHAIN        31    325       Histone-lysine N-methyltransferase ATXR4.
FT                                /FTId=PRO_0000233361.
FT   DOMAIN       42    295       SET. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00190}.
SQ   SEQUENCE   325 AA;  36134 MW;  0695D0EE9599B0A2 CRC64;
     MSRLALNRYS RCFSRLKTLT TPLFFSSSAA SNRDGDYQIG PPPIRVGLTE SAGRAVFATR
     KIGAGDLIHT AKPVVACPSL LKLDSVCYLC LKKLMGSAKF EDRGVSYCSQ ECQENSKGFL
     DVETRADWSS FDDYCRTHNF KYPLMVKRLC CMIISGARPA DCLDILQPAV LSSEMISKIE
     DGYGLLWNAF RKANFKDDDV AFLTKQWYTA ILARIRINAF RIDLVGGSCG EDLLSLAAAS
     VEGEGAVGHA VYMLPSFYNH DCDPNAHIIW LHNADARLNT LRDVEEGEEL RICYIDASMG
     YEARQTILSQ GFGFLCNCLR CQSTD
//
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