ID Q9FHF4_ARATH Unreviewed; 1353 AA.
AC Q9FHF4;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 161.
DE SubName: Full=Disease resistance protein (TIR-NBS-LRR class) family {ECO:0000313|EMBL:AED95393.1};
DE SubName: Full=Disease resistance protein-like {ECO:0000313|EMBL:BAB10819.1};
GN Name=VICTL {ECO:0000313|EMBL:AED95393.1, ECO:0000313|TAIR:AT5G46510};
GN OrderedLocusNames=At5g46510 {ECO:0000313|Araport:AT5G46510,
GN ECO:0000313|EMBL:AED95393.1};
GN ORFNames=K11I1.10 {ECO:0000313|EMBL:AED95393.1}, K11I1_10
GN {ECO:0000313|EMBL:AED95393.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:BAB10819.1};
RN [1] {ECO:0000313|EMBL:BAB10819.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10718197; DOI=10.1093/dnares/7.1.31;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. X. Sequence
RT features of the regions of 3,076,755 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:31-63(2000).
RN [2] {ECO:0000313|EMBL:AED95393.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=11130714; DOI=10.1038/35048507;
RG Kazusa DNA Research Institute;
RG Cold Spring Harbor and Washington University in St Louis Sequencing Consortium;
RG European Union Arabidopsis Genome Sequencing Consortium;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., See L.H., Vil D., Baker J.,
RA Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Dusterhoft A., Stiekema W., Pohl T., Entian K.D.,
RA Terryn N., Hartley N., Bent E., Johnson S., Langham S.A., McCullagh B.,
RA Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H.,
RA Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Lankhorst R.K., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S.,
RA Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J.,
RA Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K., Rudd S., Schoof H.,
RA Schueller C., Zaccaria P., Mewes H.W., Bevan M., Fransz P.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [3] {ECO:0000313|EMBL:AED95393.1}
RP NUCLEOTIDE SEQUENCE.
RG TAIR;
RA Swarbreck D., Lamesch P., Wilks C., Huala E.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AED95393.1}
RP NUCLEOTIDE SEQUENCE.
RA Krishnakumar V., Cheng C.-Y., Chan A.P., Schobel S., Kim M., Ferlanti E.S.,
RA Belyaeva I., Rosen B.D., Micklem G., Miller J.R., Vaughn M., Town C.D.;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
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DR EMBL; CP002688; AED95393.1; -; Genomic_DNA.
DR EMBL; AB019223; BAB10819.1; -; Genomic_DNA.
DR RefSeq; NP_199463.1; NM_124021.2.
DR AlphaFoldDB; Q9FHF4; -.
DR SMR; Q9FHF4; -.
DR STRING; 3702.Q9FHF4; -.
DR PaxDb; 3702-AT5G46510-1; -.
DR EnsemblPlants; AT5G46510.1; AT5G46510.1; AT5G46510.
DR GeneID; 834694; -.
DR Gramene; AT5G46510.1; AT5G46510.1; AT5G46510.
DR Araport; AT5G46510; -.
DR TAIR; AT5G46510; VICTL.
DR HOGENOM; CLU_001561_0_1_1; -.
DR OrthoDB; 671670at2759; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FHF4; baseline and differential.
DR GO; GO:0005829; C:cytosol; HDA:TAIR.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd02019; NK; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF228; ADP-RIBOSYL CYCLASE_CYCLIC ADP-RIBOSE HYDROLASE-RELATED; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548}.
FT DOMAIN 7..170
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1326..1353
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1353 AA; 153544 MW; 327C82397F5C28D6 CRC64;
MASSRNWVYD VFPSFSGTDV RRNFLSHLLK GLHKSVNSFR DQNMERSQSL DPMLKQAIRD
SRIALVVFSK NYASSSWCLN ELLEIVKCKE EFGQMVIPIF YCLDPSHVRH QDGDFGKNFE
ETCGRNTEEE KIQWEKALTD VANLAGFDSV TWDDEAKMIE EIANDVSGKL LSTSSTDSAE
NSIGIEDHIA NMSVLLQLEA EEVRMVGIWG SSGIGKTTIA RALFNQLSRH FPVSKFIDRA
FVYKSRETYK GANPDDPNMK LHLQGCFLSE ILGKKDIKID HLGALGERLK HQKTLIIIDD
LDDLVVLDSL VGKTNWFGCG SRIIVITNNK QFLRAHGIDH IYEVSLPSKE RAQEMFCQSA
FGENSPPEGF EELVVEIAWL AGSLPLGLTV FGSALRGRKK EYWVKMLPRL QNDLDGNIEE
TLKVSYDAIG NVKDQALFRL IACLFNHVKV RDIELLLADS GLDVNIALEN LVDKSLIHVR
NDHVEMHRLL QETGRNIVRS QSTDNPGERE FLVDSNDSRT VLSEGIGTRK VLGISLDTSK
VSEFCVHENA FKGMGNLLFL DISSKTFIEE EVKVHLPEKI NYYSVQPKQL IWDRFPLKCM
PYTFLRNLVK LEMHDSKLEK LWEGAMSFTC LKELDMWASK YLKEIPDLSK ATNIEKLDFG
HCWSLVELPS SIRNLNKLLE LNMEYCGELE TLPTGFNLKS LDYLNFNECW KLRTFPEFAT
NISNLILAET SIEEYPSNLY FKNVRELSMG KADSDENKCQ GVKPFMPMLS PTLTLLELWN
IPNLVELSSS FQNLNNLERL DICYCRNLES LPTGINLESL VSLNLFGCSR LKRFPDISTN
IKYLDLDQTG IEEVPWQIEN FFNLTKLTMK GCRELKCVSL NIFKLKHLGE VSFSNCGALT
RVDLSCYPSG VEMMKADNAD IVSEETTSSL PDSCVLNVNF MDCVNLDREP VLHQQSIIFN
SMILPGEEVP SYFTYRTSDS QPFGTSSSLP IPLLPTQLSQ PFFRFRVCAV VSASNGVYIG
VYSRFKGRIG NKFDSFGELH KFMEIEKGIH LCIFDCRIRL YKDNVPLSQL NYDHVDINIH
ITSGDWRSTV VLKEWGIRLL EDCSSAENRL GNPNSTLPHV CVEDEENLVN GTEQGDRGDV
VTETSSKQNE DVILLQRSAD SMFSRMSGKE MISYFTHRTT GTSLTNIPLP HTSPSQPFFR
FKAFAVVGCK SSGQFSYFVT HISCRFKDGF ENQPRRLYKA ENGNHLDIYE CSFPLYQGNA
SPAEMNYDRV DIQLHLRYRS DSTVRLIVWG IRLIEDCSSS ENQLDSETDQ FEECGNSDIG
HEIDQSEECE DMDDTGGICI GIDQSEERGD SDE
//
