ID Q9FKI2_ARATH Unreviewed; 145 AA.
AC Q9FKI2;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 172.
DE RecName: Full=Eukaryotic translation initiation factor 4C {ECO:0000256|ARBA:ARBA00032507};
GN Name=MXH1.2 {ECO:0000313|EMBL:AAK68729.1};
GN Synonyms=MXH1_2 {ECO:0000313|EMBL:AED94000.1};
GN OrderedLocusNames=At5g35680 {ECO:0000313|Araport:AT5G35680,
GN ECO:0000313|EMBL:AAM10261.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702 {ECO:0000313|EMBL:BAB09265.1};
RN [1] {ECO:0000313|EMBL:BAB09265.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=9679202; DOI=10.1093/dnares/5.2.131;
RA Kaneko T., Kotani H., Nakamura Y., Sato S., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. V. Sequence
RT features of the regions of 1,381,565 bp covered by twenty one physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:131-145(1998).
RN [2] {ECO:0000313|EMBL:AED94000.1, ECO:0000313|Proteomes:UP000006548}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=11130714; DOI=10.1038/35048507;
RG Kazusa DNA Research Institute;
RG Cold Spring Harbor and Washington University in St Louis Sequencing Consortium;
RG European Union Arabidopsis Genome Sequencing Consortium;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., See L.H., Vil D., Baker J.,
RA Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Dusterhoft A., Stiekema W., Pohl T., Entian K.D.,
RA Terryn N., Hartley N., Bent E., Johnson S., Langham S.A., McCullagh B.,
RA Robben J., Grymonprez B., Zimmermann W., Ramsperger U., Wedler H.,
RA Balke K., Wedler E., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Lankhorst R.K., Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S.,
RA Hempel S., Feldpausch M., Lamberth S., Villarroel R., Gielen J.,
RA Ardiles W., Bents O., Lemcke K., Kolesov G., Mayer K., Rudd S., Schoof H.,
RA Schueller C., Zaccaria P., Mewes H.W., Bevan M., Fransz P.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [3] {ECO:0000313|EMBL:AAK68729.1}
RP NUCLEOTIDE SEQUENCE.
RA Nguyen M., Karlin-Neumann G., Southwick A., Lam B., Miranda M., Palm C.J.,
RA Bowser L., Jones T., Banh J., Carninci P., Chen H., Cheuk R., Chung M.K.,
RA Hayashizaki Y., Ishida J., Kamiya A., Kawai J., Kim C., Lin J., Liu S.X.,
RA Narusaka M., Pham P.K., Sakano H., Sakurai T., Satou M., Seki M., Shinn P.,
RA Yamada K., Shinozaki K., Ecker J., Theologis A., Davis R.W.;
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AAM61169.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12093376;
RA Haas B.J., Volfovsky N., Town C.D., Troukhan M., Alexandrov N.,
RA Feldmann K.A., Flavell R.B., White O., Salzberg S.L.;
RT "Full-length messenger RNA sequences greatly improve genome annotation.";
RL Genome Biol. 3:RESEARCH0029-RESEARCH0029(2002).
RN [5] {ECO:0000313|EMBL:AAM10261.1}
RP NUCLEOTIDE SEQUENCE.
RA Southwick A., Karlin-Neumann G., Nguyen M., Lam B., Miranda M., Palm C.J.,
RA Bowser L., Jones T., Banh J., Carninci P., Chen H., Cheuk R., Chung M.K.,
RA Hayashizaki Y., Ishida J., Kamiya A., Kawai J., Kim C., Lin J., Liu S.X.,
RA Narusaka M., Pham P.K., Sakano H., Sakurai T., Satou M., Seki M., Shinn P.,
RA Yamada K., Shinozaki K., Ecker J., Theologis A., Davis R.W.;
RL Submitted (FEB-2002) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:AAM61169.1}
RP NUCLEOTIDE SEQUENCE.
RA Brover V., Troukhan M., Alexandrov N., Lu Y.-P., Flavell R., Feldmann K.;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:AAM61169.1}
RP NUCLEOTIDE SEQUENCE.
RA Alexandrov N.A., Troukhan M.E., Brover V.V., Flavell R.B., Feldmann K.A.;
RT "Features of Arabidopsis genes and genome discovered using full-length
RT cDNAs.";
RL Plant Mol. Biol. 60:71-87(2006).
RN [8] {ECO:0000313|EMBL:AED94000.1}
RP NUCLEOTIDE SEQUENCE.
RG TAIR;
RA Swarbreck D., Lamesch P., Wilks C., Huala E.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
RN [9] {ECO:0000313|EMBL:AED94000.1}
RP NUCLEOTIDE SEQUENCE.
RA Krishnakumar V., Cheng C.-Y., Chan A.P., Schobel S., Kim M., Ferlanti E.S.,
RA Belyaeva I., Rosen B.D., Micklem G., Miller J.R., Vaughn M., Town C.D.;
RL Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
RN [10] {ECO:0000313|Proteomes:UP000006548}
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia {ECO:0000313|Proteomes:UP000006548};
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
CC -!- FUNCTION: Seems to be required for maximal rate of protein
CC biosynthesis. Enhances ribosome dissociation into subunits and
CC stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal
CC subunits. {ECO:0000256|RuleBase:RU004365}.
CC -!- SIMILARITY: Belongs to the eIF-1A family.
CC {ECO:0000256|ARBA:ARBA00007392, ECO:0000256|RuleBase:RU004364}.
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DR EMBL; AY042789; AAK68729.1; -; mRNA.
DR EMBL; AY081699; AAM10261.1; -; mRNA.
DR EMBL; AY084605; AAM61169.1; -; mRNA.
DR EMBL; CP002688; AED94000.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94001.1; -; Genomic_DNA.
DR EMBL; AB011485; BAB09265.1; -; Genomic_DNA.
DR RefSeq; NP_198418.1; NM_122959.4.
DR RefSeq; NP_851095.1; NM_180764.3.
DR AlphaFoldDB; Q9FKI2; -.
DR SMR; Q9FKI2; -.
DR ProteomicsDB; 193545; -.
DR EnsemblPlants; AT5G35680.1; AT5G35680.1; AT5G35680.
DR EnsemblPlants; AT5G35680.2; AT5G35680.2; AT5G35680.
DR GeneID; 833541; -.
DR Gramene; AT5G35680.1; AT5G35680.1; AT5G35680.
DR Gramene; AT5G35680.2; AT5G35680.2; AT5G35680.
DR Araport; AT5G35680; -.
DR TAIR; AT5G35680; -.
DR HOGENOM; CLU_109098_0_1_1; -.
DR OMA; WRYTRTE; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FKI2; baseline and differential.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR CDD; cd05793; S1_IF1A; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR HAMAP; MF_00216; aIF_1A; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR006196; RNA-binding_domain_S1_IF1.
DR InterPro; IPR001253; TIF_eIF-1A.
DR InterPro; IPR018104; TIF_eIF-1A_CS.
DR NCBIfam; TIGR00523; eIF-1A; 1.
DR PANTHER; PTHR21668; EIF-1A; 1.
DR PANTHER; PTHR21668:SF16; EUKARYOTIC TRANSLATION INITIATION FACTOR 4C; 1.
DR Pfam; PF01176; eIF-1a; 1.
DR SMART; SM00652; eIF1a; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR PROSITE; PS01262; IF1A; 1.
DR PROSITE; PS50832; S1_IF1_TYPE; 1.
PE 1: Evidence at protein level;
KW Initiation factor {ECO:0000256|PROSITE-ProRule:PRU00181,
KW ECO:0000256|RuleBase:RU004365};
KW Protein biosynthesis {ECO:0000256|PROSITE-ProRule:PRU00181,
KW ECO:0000256|RuleBase:RU004365};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q9FKI2,
KW ECO:0007829|ProteomicsDB:Q9FKI2};
KW Reference proteome {ECO:0000313|Proteomes:UP000006548}.
FT DOMAIN 22..96
FT /note="S1-like"
FT /evidence="ECO:0000259|PROSITE:PS50832"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 145 AA; 16590 MW; 8CAC58EC46308E92 CRC64;
MPKNKGKGGK NRKRGKNEAD DEKRELIFKE DGQEYAQVLR MLGNGRCDVM CIDGVKRLCH
IRGKMHKKVW IAAGDIILVG LRDYQDDKAD VILKYMSDEA RLLKAYGELP ENTRLNEGIV
GDLDDDDDVV GEDYIEFEDE DIDRI
//
