ID ZHD13_ARATH Reviewed; 242 AA.
AC Q9FMY7; Q8LGB1;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 132.
DE RecName: Full=Zinc-finger homeodomain protein 13;
DE Short=AtZHD13;
DE AltName: Full=Homeobox protein 27;
DE Short=AtHB-27;
GN Name=ZHD13; Synonyms=HB27; OrderedLocusNames=At5g42780; ORFNames=MJB21.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9501997; DOI=10.1093/dnares/4.6.401;
RA Nakamura Y., Sato S., Kaneko T., Kotani H., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. III. Sequence
RT features of the regions of 1,191,918 bp covered by seventeen physically
RT assigned P1 clones.";
RL DNA Res. 4:401-414(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP INTERACTION WITH ZHD11, TISSUE SPECIFICITY, AND GENE FAMILY.
RX PubMed=16428600; DOI=10.1104/pp.105.070565;
RA Tan Q.K., Irish V.F.;
RT "The Arabidopsis zinc finger-homeodomain genes encode proteins with unique
RT biochemical properties that are coordinately expressed during floral
RT development.";
RL Plant Physiol. 140:1095-1108(2006).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18713354; DOI=10.1111/j.1744-7909.2008.00681.x;
RA Hu W., dePamphilis C.W., Ma H.;
RT "Phylogenetic analysis of the plant-specific zinc finger-homeobox and mini
RT zinc finger gene families.";
RL J. Integr. Plant Biol. 50:1031-1045(2008).
RN [7]
RP INTERACTION WITH MIF1; MIF2 AND MIF3, GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=21059647; DOI=10.1074/jbc.m110.167692;
RA Hong S.-Y., Kim O.-K., Kim S.-G., Yang M.-S., Park C.-M.;
RT "Nuclear import and DNA binding of the ZHD5 transcription factor is
RT modulated by a competitive peptide inhibitor in Arabidopsis.";
RL J. Biol. Chem. 286:1659-1668(2011).
CC -!- FUNCTION: Putative transcription factor.
CC -!- SUBUNIT: Homo- and heterodimer with other ZFHD proteins (By
CC similarity). Interacts with MIF1, MIF2 and MIF3; these interactions
CC prevent nuclear localization and DNA-binding to inhibit transcription
CC regulation activity. Binds to ZHD11. {ECO:0000250,
CC ECO:0000269|PubMed:16428600, ECO:0000269|PubMed:21059647}.
CC -!- INTERACTION:
CC Q9FMY7; Q9FIW9: ZHD10; NbExp=4; IntAct=EBI-1806559, EBI-1806298;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Interactions with MIF
CC proteins prevent nuclear subcellular location and leads to a scattered
CC repartition throughout the cytoplasm. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in flowers.
CC {ECO:0000269|PubMed:16428600}.
CC -!- DOMAIN: The homeodomain differs form the typical one by having namely 4
CC instead of 3 extra amino acids inserted in the loop between helix 1 and
CC helix 2.
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DR EMBL; AB007647; BAB10634.1; -; Genomic_DNA.
DR EMBL; CP002688; AED94862.1; -; Genomic_DNA.
DR EMBL; BT002832; AAO22651.1; -; mRNA.
DR EMBL; BT004379; AAO42373.1; -; mRNA.
DR EMBL; AY084367; AAM60948.1; -; mRNA.
DR RefSeq; NP_199092.1; NM_123643.3.
DR AlphaFoldDB; Q9FMY7; -.
DR SMR; Q9FMY7; -.
DR BioGRID; 19538; 14.
DR IntAct; Q9FMY7; 15.
DR STRING; 3702.Q9FMY7; -.
DR PaxDb; 3702-AT5G42780-1; -.
DR ProteomicsDB; 242348; -.
DR EnsemblPlants; AT5G42780.1; AT5G42780.1; AT5G42780.
DR GeneID; 834288; -.
DR Gramene; AT5G42780.1; AT5G42780.1; AT5G42780.
DR KEGG; ath:AT5G42780; -.
DR Araport; AT5G42780; -.
DR TAIR; AT5G42780; HB27.
DR eggNOG; ENOG502QZSB; Eukaryota.
DR HOGENOM; CLU_039237_2_2_1; -.
DR InParanoid; Q9FMY7; -.
DR OMA; TTAYDGC; -.
DR OrthoDB; 648548at2759; -.
DR PRO; PR:Q9FMY7; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FMY7; baseline and differential.
DR Genevisible; Q9FMY7; AT.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISS:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR006455; Homeodomain_ZF_HD.
DR InterPro; IPR006456; ZF_HD_homeobox_Cys/His_dimer.
DR NCBIfam; TIGR01565; homeo_ZF_HD; 1.
DR NCBIfam; TIGR01566; ZF_HD_prot_N; 1.
DR PANTHER; PTHR31948:SF190; ZINC-FINGER HOMEODOMAIN PROTEIN 13; 1.
DR PANTHER; PTHR31948; ZINC-FINGER HOMEODOMAIN PROTEIN 2; 1.
DR Pfam; PF04770; ZF-HD_dimer; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51523; ZF_HD_DIMER; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Homeobox; Metal-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..242
FT /note="Zinc-finger homeodomain protein 13"
FT /id="PRO_0000426026"
FT ZN_FING 64..111
FT /note="ZF-HD dimerization-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00856"
FT DNA_BIND 179..238
FT /note="Homeobox"
FT REGION 144..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 231
FT /note="Required for DNA-binding"
FT /evidence="ECO:0000250"
FT CONFLICT 123
FT /note="V -> I (in Ref. 4; AAM60948)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 242 AA; 27968 MW; 8BBC8FD44858FA4F CRC64;
MDEIKPKKEE NSKRRRNVKP ICRETGDHVH YLPTCKTKPK PTRTHHAPPP ILDSIFKVTH
KPHYYECRKN HAADIGTTAY DGCGEFVSST GEEDSLNCAA CGCHRNFHRE ELIPENGGVT
ETVLEVLKIS SCQFRRIFCS PYGGGKSEGK KKKKEKESYG GDPIIKDRFG GAEEEEGIVK
RLKTKFTAEQ TEKMRDYAEK LRWKVRPERQ EEVEEFCVEI GVNRKNFRIW MNNHKDKIII
DE
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