GenomeNet

Database: UniProt
Entry: Q9FYH7
LinkDB: Q9FYH7
Original site: Q9FYH7 
ID   VSR6_ARATH              Reviewed;         631 AA.
AC   Q9FYH7; F4I7T2;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 3.
DT   13-FEB-2019, entry version 117.
DE   RecName: Full=Vacuolar-sorting receptor 6;
DE            Short=AtVSR6;
DE   AltName: Full=BP80-like protein d;
DE            Short=AtBP80d;
DE   AltName: Full=Epidermal growth factor receptor-like protein 6;
DE            Short=AtELP6;
DE   Flags: Precursor;
GN   Name=VSR6; Synonyms=BP80D, ELP6; OrderedLocusNames=At1g30900;
GN   ORFNames=F17F8.23;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S.,
RA   White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y.,
RA   Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W.,
RA   Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K.,
RA   Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y.,
RA   Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L.,
RA   Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E.,
RA   Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B.,
RA   Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P.,
RA   Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A.,
RA   Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I.,
RA   Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D.,
RA   Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M.,
RA   Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M.,
RA   Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana
RT   reference genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=12493849; DOI=10.1093/jxb/erg018;
RA   Laval V., Masclaux F., Serin A., Carriere M., Roldan C., Devic M.,
RA   Pont-Lezica R.F., Galaud J.-P.;
RT   "Seed germination is blocked in Arabidopsis putative vacuolar sorting
RT   receptor (atbp80) antisense transformants.";
RL   J. Exp. Bot. 54:213-221(2003).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=14657332; DOI=10.1073/pnas.2530568100;
RA   Shimada T., Fuji K., Tamura K., Kondo M., Nishimura M.,
RA   Hara-Nishimura I.;
RT   "Vacuolar sorting receptor for seed storage proteins in Arabidopsis
RT   thaliana.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:16095-16100(2003).
CC   -!- FUNCTION: Vacuolar-sorting receptor (VSR) involved in clathrin-
CC       coated vesicles sorting from Golgi apparatus to vacuoles.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}. Golgi apparatus membrane
CC       {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC       Cytoplasmic vesicle, clathrin-coated vesicle membrane
CC       {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
CC       Prevacuolar compartment membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in seedlings, roots, leaves, flowers
CC       and siliques. {ECO:0000269|PubMed:12493849}.
CC   -!- DOMAIN: The tyrosine-based internalization signal may be involved
CC       in trafficking at the TGN. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VSR (BP-80) family. {ECO:0000305}.
CC   -!- CAUTION: Was originally erroneously termed BP80E.
CC       {ECO:0000305|PubMed:12493849}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF98196.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; AC000107; AAF98196.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE31291.1; -; Genomic_DNA.
DR   PIR; G86434; G86434.
DR   RefSeq; NP_174375.1; NM_102827.2.
DR   UniGene; At.51844; -.
DR   ProteinModelPortal; Q9FYH7; -.
DR   SMR; Q9FYH7; -.
DR   STRING; 3702.AT1G30900.1; -.
DR   PaxDb; Q9FYH7; -.
DR   PRIDE; Q9FYH7; -.
DR   EnsemblPlants; AT1G30900.1; AT1G30900.1; AT1G30900.
DR   GeneID; 839974; -.
DR   Gramene; AT1G30900.1; AT1G30900.1; AT1G30900.
DR   KEGG; ath:AT1G30900; -.
DR   Araport; AT1G30900; -.
DR   TAIR; locus:2015726; AT1G30900.
DR   eggNOG; ENOG410IHDN; Eukaryota.
DR   eggNOG; ENOG41105IF; LUCA.
DR   HOGENOM; HOG000241019; -.
DR   InParanoid; Q9FYH7; -.
DR   OMA; VPAMGRF; -.
DR   OrthoDB; 1428226at2759; -.
DR   PRO; PR:Q9FYH7; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   Genevisible; Q9FYH7; AT.
DR   GO; GO:0030665; C:clathrin-coated vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005768; C:endosome; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0017119; C:Golgi transport complex; IBA:GO_Central.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0005802; C:trans-Golgi network; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IBA:GO_Central.
DR   GO; GO:0006896; P:Golgi to vacuole transport; IBA:GO_Central.
DR   GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR003137; PA_domain.
DR   Pfam; PF02225; PA; 1.
DR   SMART; SM00179; EGF_CA; 1.
DR   PROSITE; PS00010; ASX_HYDROXYL; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 1.
DR   PROSITE; PS01187; EGF_CA; 1.
PE   2: Evidence at transcript level;
KW   Calcium; Complete proteome; Cytoplasmic vesicle; Disulfide bond;
KW   EGF-like domain; Glycoprotein; Golgi apparatus; Membrane;
KW   Protein transport; Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix; Transport.
FT   SIGNAL        1     25       {ECO:0000255}.
FT   CHAIN        26    631       Vacuolar-sorting receptor 6.
FT                                /FTId=PRO_0000036468.
FT   TOPO_DOM     26    563       Lumenal. {ECO:0000255}.
FT   TRANSMEM    564    584       Helical. {ECO:0000255}.
FT   TOPO_DOM    585    631       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       57    165       PA.
FT   DOMAIN      413    463       EGF-like 1.
FT   DOMAIN      494    540       EGF-like 2.
FT   MOTIF       604    607       Tyrosine-based internalization motif.
FT                                {ECO:0000250}.
FT   CARBOHYD    294    294       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    431    431       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID    417    435       {ECO:0000250}.
FT   DISULFID    424    444       {ECO:0000250}.
FT   DISULFID    446    462       {ECO:0000250}.
FT   DISULFID    498    511       {ECO:0000250}.
FT   DISULFID    530    539       {ECO:0000250}.
SQ   SEQUENCE   631 AA;  70258 MW;  6BC20BF63461327D CRC64;
     MSLIHKGATL ALFLALTMVV NGVFGRFIVE KSSVTILNPL AMRSKHDAAI ANFGVPNYGG
     YMIGSVVYAG QGAYGCDSFD KTFKPKFPRP TILIIDRGEC YFALKVWNGQ QSGVAAVLVA
     DNVDEPLITM DSPEESKEAD DFIEKLNIPS ALIDFSFANT LKQALKKGEE VVLKIDWSES
     LPHPDERVEY ELWTNTNDEC GARCDEQMNF VKNFKGHAQI LEKGGYSLFT PHYITWFCPK
     DYVSSNQCKS QCINQGRYCA PDPEQDFGDG YDGKDIVFEN LRQLCVHKVA KENNRSWVWW
     DYVTDFHIRC SMKEKKYSKE CAERVVESLG LPLDKIKKCI GDPDANVENE VLKAEQALQV
     GQGDRGDVTI LPTLIVNNAQ YRGKLERNAV LKAICSGFKE RTEPGICLSG DIETNECLEA
     NGGCWEDKKS NVTACKDTFR GRVCECPVVN GVQYKGDGYT SCEPYGPARC SINQGGCWSE
     TKKGLTFSAC SNLETSGCRC PPGFKGDGLK CEDIDECKEQ SACQCDGCNC KNKWGGFECK
     CSGNRLYMKE QDTCIERSGS RIGWFPTFVI LAAVASICVG GYVFYKYRLR SYMDSEIMAI
     MSQYMPLESQ NTTDPMTGES QHQQLRLTSA A
//
DBGET integrated database retrieval system