ID MDGA2_MACFA Reviewed; 451 AA.
AC Q9GMT4;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 2.
DT 27-MAR-2024, entry version 96.
DE RecName: Full=MAM domain-containing glycosylphosphatidylinositol anchor protein 2;
DE AltName: Full=MAM domain-containing protein 1;
DE Flags: Precursor; Fragment;
GN Name=MDGA2; Synonyms=MAMDC1; ORFNames=QccE-16296;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RX PubMed=11574149; DOI=10.1016/s0378-1119(01)00665-5;
RA Osada N., Hida M., Kususda J., Tanuma R., Iseki K., Hirata M., Suto Y.,
RA Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K.;
RT "Assignment of 118 novel cDNAs of cynomolgus monkey brain to human
RT chromosomes.";
RL Gene 275:31-37(2001).
RN [2]
RP ERRATUM OF PUBMED:11574149.
RA Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirata M., Suto Y.,
RA Hirai M., Terao K., Suzuki Y., Sugano S., Hashimoto K., Kususda J.;
RL Gene 278:267-267(2001).
CC -!- FUNCTION: May be involved in cell-cell interactions. {ECO:0000250}.
CC -!- SUBUNIT: Interacts (through the Ig-like domains) with NLGN2.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB12260.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB047834; BAB12260.1; ALT_INIT; mRNA.
DR AlphaFoldDB; Q9GMT4; -.
DR SMR; Q9GMT4; -.
DR STRING; 9541.ENSMFAP00000018716; -.
DR GlyCosmos; Q9GMT4; 2 sites, No reported glycans.
DR eggNOG; ENOG502QSMD; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR CDD; cd06263; MAM; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR000998; MAM_dom.
DR PANTHER; PTHR23282; APICAL ENDOSOMAL GLYCOPROTEIN PRECURSOR; 1.
DR PANTHER; PTHR23282:SF123; MAM DOMAIN-CONTAINING GLYCOSYLPHOSPHATIDYLINOSITOL ANCHOR PROTEIN 1; 1.
DR Pfam; PF00629; MAM; 1.
DR PRINTS; PR00020; MAMDOMAIN.
DR SMART; SM00137; MAM; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50060; MAM_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor;
KW Immunoglobulin domain; Lipoprotein; Membrane; Reference proteome.
FT CHAIN <1..426
FT /note="MAM domain-containing glycosylphosphatidylinositol
FT anchor protein 2"
FT /id="PRO_0000072681"
FT PROPEP 427..451
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000292046"
FT DOMAIN 35..122
FT /note="Ig-like"
FT DOMAIN 133..234
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 241..416
FT /note="MAM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00128"
FT LIPID 426
FT /note="GPI-anchor amidated aspartate"
FT /evidence="ECO:0000255"
FT CARBOHYD 105
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 56..106
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT NON_TER 1
SQ SEQUENCE 451 AA; 51552 MW; 250BD3A38A6F7564 CRC64;
AREMSGMYRC QTSQYNGFNV KPREALVQLI VQYPPAVEPA FLEIRQGQDR SVTMSCRVLR
AYPIRVLTYE WRLGNKLLRT GQFDSQEYTE YPVKSLSNEN YGVYNCSIIN EAGAGRCSFL
VTGKAYAPEF YYDTYNPVWQ NRHRVYSYSL QWTQMNPDAV DRIVAYRLGI RQAGQQRWWE
QEIKINGNIQ KGELITYNLT ELIKPEAYEV RLTPLTKFGE GDSTIRVIKY SAPVNPHLRE
FHCGFEDGNI CLFTQDDTDN FDWTKQSTAT RNTKYTPNTG PNADRSGSKE GFYMYIETSR
PRLEGEKARL LSPVFSIAPK NPYGPTNTAY CFSFFYHMYG QHIGVLNVYL RLKGQTTIEN
PLWSSSGNKG QRWNEAHVNI YPITSFQLIF EGIRGPGIEG DIAIDDVSIA EGECAKQDLA
TKNSVDGAVG ILVHIWLFPI IVLISILSPR R
//
