ID Q9GMZ8_FELCA Unreviewed; 292 AA.
AC Q9GMZ8;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 24-JAN-2024, entry version 131.
DE SubName: Full=B-lymphocyte activation antigen B7-1 (CD80) {ECO:0000313|EMBL:BAB11687.1};
DE SubName: Full=CD80 molecule {ECO:0000313|Ensembl:ENSFCAP00000008890.3};
GN Name=CD80 {ECO:0000313|EMBL:BAB11687.1,
GN ECO:0000313|Ensembl:ENSFCAP00000008890.3,
GN ECO:0000313|VGNC:VGNC:97376};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|EMBL:BAB11687.1};
RN [1] {ECO:0000313|EMBL:BAB11687.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=11029611; DOI=10.1046/j.1365-2370.2000.00221.x;
RA Nishimura Y., Shimojima M., Miyazawa T., Sato E., Nakamura K., Izumiya Y.,
RA Ikeda Y., Mikami T., Takahashi E.;
RT "Molecular cloning of the cDNAs encoding the feline B-lymphocyte activation
RT antigen B7-1 (CD80) and B7-2 (CD86) homologues which interact with human
RT CTLA4-Ig.";
RL Eur. J. Immunogenet. 27:427-430(2000).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000008890.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008890.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000008890.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008890.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|Ensembl:ENSFCAP00000008890.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000008890.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AANG04001815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB030651; BAB11687.1; -; mRNA.
DR RefSeq; XP_019694786.1; XM_019839227.1.
DR STRING; 9685.ENSFCAP00000008890; -.
DR MEROPS; I43.001; -.
DR PaxDb; 9685-ENSFCAP00000008890; -.
DR Ensembl; ENSFCAT00000009587.6; ENSFCAP00000008890.3; ENSFCAG00000009585.6.
DR VGNC; VGNC:97376; CD80.
DR eggNOG; ENOG502S5B5; Eukaryota.
DR GeneTree; ENSGT00940000162632; -.
DR HOGENOM; CLU_071073_2_0_1; -.
DR OMA; HMTSVML; -.
DR OrthoDB; 5401666at2759; -.
DR Proteomes; UP000011712; Chromosome C2.
DR Bgee; ENSFCAG00000009585; Expressed in spleen and 10 other cell types or tissues.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0098636; C:protein complex involved in cell adhesion; IEA:Ensembl.
DR GO; GO:0015026; F:coreceptor activity; IEA:InterPro.
DR GO; GO:0048018; F:receptor ligand activity; IEA:Ensembl.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IBA:GO_Central.
DR GO; GO:0006955; P:immune response; IBA:GO_Central.
DR GO; GO:0002710; P:negative regulation of T cell mediated immunity; IEA:Ensembl.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR GO; GO:0042102; P:positive regulation of T cell proliferation; IBA:GO_Central.
DR GO; GO:0042110; P:T cell activation; IEA:Ensembl.
DR GO; GO:0031295; P:T cell costimulation; IBA:GO_Central.
DR CDD; cd16083; IgC1_CD80; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR013162; CD80_C2-set.
DR InterPro; IPR037676; CD80_IgC.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR25466; T-LYMPHOCYTE ACTIVATION ANTIGEN; 1.
DR PANTHER; PTHR25466:SF4; T-LYMPHOCYTE ACTIVATION ANTIGEN CD80; 1.
DR Pfam; PF08205; C2-set_2; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 2: Evidence at transcript level;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 243..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 17..132
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 145..226
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 292 AA; 33540 MW; ED9AEECE10D30401 CRC64;
MDHAAKWKTP LLKHPYPKLF PLLMLASLFY FCSGIIQVNK TVEEVAVLSC DYNISTKELT
EIRIYWQKDD EMVLAVMSGK VQVWPKYKNR TFTDVTDNHS IVIMALRLSD NGKYTCIIQK
IEKGSYKVKH LTSVMLLVRA DFPVPSITDL GNPSHNIKRI MCLTSGGFPK PHLSWLENEE
ELNAINTTVS QDPETELYTI SSELDFNMTN NHSFLCLVKY GNLLVSQIFN WQKSEPQPSN
NQLWIIILSS VVSGIVVITA LTLRCLVHRP AARWRQREMG RARKWKRSHL ST
//
