ID Q9GRY9_CAEEL Unreviewed; 413 AA.
AC Q9GRY9;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 155.
DE SubName: Full=K Homology domain-containing protein {ECO:0000313|EMBL:CAC14410.1};
GN Name=nova-1 {ECO:0000313|EMBL:CAC14410.1,
GN ECO:0000313|WormBase:Y59A8B.10a};
GN ORFNames=CELE_Y59A8B.10 {ECO:0000313|EMBL:CAC14410.1}, Y59A8B.10
GN {ECO:0000313|WormBase:Y59A8B.10a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000313|EMBL:CAC14410.1, ECO:0000313|Proteomes:UP000001940};
RN [1] {ECO:0000313|EMBL:CAC14410.1, ECO:0000313|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000313|EMBL:CAC14410.1,
RC ECO:0000313|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RA Sulson J.E., Waterston R.;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- INTERACTION:
CC Q9GRY9; P91277: hrpk-1; NbExp=3; IntAct=EBI-320508, EBI-320476;
CC Q9GRY9; Q9XVS2: sup-46; NbExp=4; IntAct=EBI-320508, EBI-311961;
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DR EMBL; BX284605; CAC14410.1; -; Genomic_DNA.
DR RefSeq; NP_001256769.1; NM_001269840.1.
DR AlphaFoldDB; Q9GRY9; -.
DR SMR; Q9GRY9; -.
DR DIP; DIP-24651N; -.
DR IntAct; Q9GRY9; 12.
DR EPD; Q9GRY9; -.
DR PeptideAtlas; Q9GRY9; -.
DR EnsemblMetazoa; Y59A8B.10a.1; Y59A8B.10a.1; WBGene00013347.
DR GeneID; 180183; -.
DR UCSC; Y59A8B.10; c. elegans.
DR AGR; WB:WBGene00013347; -.
DR WormBase; Y59A8B.10a; CE26206; WBGene00013347; nova-1.
DR eggNOG; KOG2191; Eukaryota.
DR GeneTree; ENSGT00940000171065; -.
DR HOGENOM; CLU_022670_6_1_1; -.
DR OMA; REKCADQ; -.
DR OrthoDB; 5478127at2759; -.
DR PhylomeDB; Q9GRY9; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00013347; Expressed in pharyngeal muscle cell (C elegans) and 4 other cell types or tissues.
DR ExpressionAtlas; Q9GRY9; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003729; F:mRNA binding; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IBA:GO_Central.
DR CDD; cd22435; KH-I_NOVA_rpt1; 1.
DR CDD; cd22436; KH-I_NOVA_rpt2; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 2.
DR InterPro; IPR047275; KH-I_NOVA_rpt1.
DR InterPro; IPR047276; KH-I_NOVA_rpt2.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR PANTHER; PTHR10288; KH DOMAIN CONTAINING RNA BINDING PROTEIN; 1.
DR PANTHER; PTHR10288:SF142; RNA-BINDING PROTEIN PASILLA; 1.
DR Pfam; PF00013; KH_1; 2.
DR SMART; SM00322; KH; 2.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 2.
DR PROSITE; PS50084; KH_TYPE_1; 2.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:Q9GRY9,
KW ECO:0007829|PeptideAtlas:Q9GRY9};
KW Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT DOMAIN 40..113
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 132..208
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 372..413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 413 AA; 42115 MW; 4431E90B9EC82789 CRC64;
MAEEFTEDSK TQQGVKRTQD ASDGPANKKA HFGGEEEGGD HLSIKILIPS NAVGAIIGKG
GEAMRNLKND NNCRVQMSKN SETYPGTSER ICLVKGRLNN IMAVIESIQD KIREKCADQG
GSDAFDHKNT SRGAEIKIVM PNTSAGMVIG KSGANIKDIR EQFGCQIQVY PKAGSVEAKT
SLERVVTVAH DEASALLQAA SRVLEKVASD PHHASEINKE DFGKGSGPSG SANSGPSGGG
GGGGGGGQSN NNSSFSSVPA FNGGGGGGGG MNVGAAGFGG GGGQGYGGPQ FGGQGGPQFG
NGNNKYPMSG LGNNELLSFL DNLQSTLRTS GFNEQSVSEV MQAMQVLAKY NIMGLGLGLG
VAAMAQMRTG QESQGMSANH GSAGFGDGYG QGGVQGGPQG PQGGGGDQSY WRR
//
