ID MAJE_PSEAE Reviewed; 172 AA.
AC Q9HI36;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE RecName: Full=Major exported protein;
DE AltName: Full=Secreted protein hcp;
GN Name=hcpA; OrderedLocusNames=PA0263;
GN and
GN Name=hcpB; OrderedLocusNames=PA1512;
GN and
GN Name=hcpC; OrderedLocusNames=PA5267;
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC PRS 101 / PAO1;
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the hcp1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE004091; AAG03652.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG04901.1; -; Genomic_DNA.
DR EMBL; AE004091; AAG08652.1; -; Genomic_DNA.
DR PIR; G82987; G82987.
DR RefSeq; NP_248954.1; NC_002516.2.
DR RefSeq; NP_250203.1; NC_002516.2.
DR RefSeq; NP_253954.1; NC_002516.2.
DR RefSeq; WP_003083317.1; NZ_JASSSF010000020.1.
DR PDB; 3HE1; X-ray; 2.10 A; A/B/C/D/E/F=1-172.
DR PDBsum; 3HE1; -.
DR AlphaFoldDB; Q9HI36; -.
DR SMR; Q9HI36; -.
DR STRING; 208964.PA0263; -.
DR PaxDb; 208964-PA0263; -.
DR DNASU; 879579; -.
DR GeneID; 879579; -.
DR GeneID; 880866; -.
DR GeneID; 883081; -.
DR KEGG; pae:PA0263; -.
DR KEGG; pae:PA1512; -.
DR KEGG; pae:PA5267; -.
DR PATRIC; fig|208964.12.peg.1564; -.
DR PseudoCAP; PA5267; -.
DR HOGENOM; CLU_116190_1_0_6; -.
DR InParanoid; Q9HI36; -.
DR OrthoDB; 5674026at2; -.
DR PhylomeDB; Q9HI36; -.
DR EvolutionaryTrace; Q9HI36; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 2.30.110.20; Hcp1-like; 1.
DR InterPro; IPR036624; Hcp1-lik_sf.
DR InterPro; IPR008514; T6SS_Hcp.
DR NCBIfam; TIGR03344; VI_effect_Hcp1; 1.
DR PANTHER; PTHR34319; MAJOR EXPORTED PROTEIN; 1.
DR PANTHER; PTHR34319:SF6; MAJOR EXPORTED PROTEIN; 1.
DR Pfam; PF05638; T6SS_HCP; 1.
DR SUPFAM; SSF141452; Hcp1-like; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Secreted.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250"
FT CHAIN 2..172
FT /note="Major exported protein"
FT /id="PRO_0000288024"
FT STRAND 5..11
FT /evidence="ECO:0007829|PDB:3HE1"
FT TURN 12..14
FT /evidence="ECO:0007829|PDB:3HE1"
FT TURN 17..20
FT /evidence="ECO:0007829|PDB:3HE1"
FT HELIX 24..27
FT /evidence="ECO:0007829|PDB:3HE1"
FT HELIX 28..30
FT /evidence="ECO:0007829|PDB:3HE1"
FT STRAND 38..41
FT /evidence="ECO:0007829|PDB:3HE1"
FT STRAND 43..45
FT /evidence="ECO:0007829|PDB:3HE1"
FT STRAND 68..74
FT /evidence="ECO:0007829|PDB:3HE1"
FT HELIX 78..87
FT /evidence="ECO:0007829|PDB:3HE1"
FT STRAND 90..101
FT /evidence="ECO:0007829|PDB:3HE1"
FT STRAND 105..127
FT /evidence="ECO:0007829|PDB:3HE1"
FT STRAND 140..147
FT /evidence="ECO:0007829|PDB:3HE1"
FT STRAND 149..155
FT /evidence="ECO:0007829|PDB:3HE1"
FT TURN 156..158
FT /evidence="ECO:0007829|PDB:3HE1"
FT STRAND 161..165
FT /evidence="ECO:0007829|PDB:3HE1"
SQ SEQUENCE 172 AA; 19091 MW; 8565ABE2F64B9577 CRC64;
MATPAYMSIT GTKQGLITAG AFTEDSVGNT YQEGHEDQVM VQGFNHEVII PRDPQSGQPT
GQRVHKPVVI TKVFDKASPL LLAALTSGER LTKVEIQWYR TSAAGTQEHY YTTVLEDAII
VDIKDYMHNC QDPGNAHFTH LEDVHFTYRK ITWTHEVSGT SGSDDWRSPV AG
//
