ID Q9HKV2_THEAC Unreviewed; 529 AA.
AC Q9HKV2;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE SubName: Full=p-methyltransferase related protein {ECO:0000313|EMBL:CAC11633.1};
GN OrderedLocusNames=Ta0491 {ECO:0000313|EMBL:CAC11633.1};
OS Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS 15155 / AMRC-C165).
OC Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC Thermoplasmataceae; Thermoplasma.
OX NCBI_TaxID=273075 {ECO:0000313|EMBL:CAC11633.1, ECO:0000313|Proteomes:UP000001024};
RN [1] {ECO:0000313|EMBL:CAC11633.1, ECO:0000313|Proteomes:UP000001024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165
RC {ECO:0000313|Proteomes:UP000001024};
RX PubMed=11029001; DOI=10.1038/35035069;
RA Ruepp A., Graml W., Santos-Martinez M.L., Koretke K.K., Volker C.,
RA Mewes H.W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT acidophilum.";
RL Nature 407:508-513(2000).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL445064; CAC11633.1; -; Genomic_DNA.
DR RefSeq; WP_010900918.1; NC_002578.1.
DR AlphaFoldDB; Q9HKV2; -.
DR STRING; 273075.gene:9571711; -.
DR PaxDb; 273075-Ta0491; -.
DR EnsemblBacteria; CAC11633; CAC11633; CAC11633.
DR GeneID; 1456096; -.
DR KEGG; tac:Ta0491; -.
DR eggNOG; arCOG01356; Archaea.
DR HOGENOM; CLU_021572_4_4_2; -.
DR InParanoid; Q9HKV2; -.
DR OrthoDB; 2305at2157; -.
DR Proteomes; UP000001024; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR CDD; cd02068; radical_SAM_B12_BD; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR036724; Cobalamin-bd_sf.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR034466; Methyltransferase_Class_B.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR PANTHER; PTHR43409:SF7; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE; 1.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR Pfam; PF02310; B12-binding; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDG01123; methyltransferase_(Class_B); 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW 4Fe-4S {ECO:0000256|ARBA:ARBA00022485};
KW Iron {ECO:0000256|ARBA:ARBA00022485};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00022485};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022485};
KW Reference proteome {ECO:0000313|Proteomes:UP000001024}.
FT DOMAIN 12..144
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 190..420
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 529 AA; 59996 MW; EBEBE7C95D0930A4 CRC64;
MKVLLIKPLN PTGSGYTTKF GFLPTPLGLQ VLAAQARAIG INDVRIVDME ADDLTADQMV
EYVERWRPDV IGITLHATAA HAFSQDLAKR IKAIYNPLIV AGGHQATFVP GELLDNGFDI
IVLGEGDEAF RDVLEHYRDN ADFSDIPGII FKSGNMKIRT EKRELIDDLD RLPIPAFDLV
DKERYTFKVF GEGSVATVET ARGCPYACDF CSVTPTWGNK WRNKSNDRIM EELRIVKSLG
YRWVFFTDDI FVVYPNVKQR SDLFDRIIEE DLGLKFIVQM RADVTSKNPD LIRKASQAGL
TIAFLGIESG SEEVLKAMHK GIMTSASVNA VKILTQNNIV VLGGMMLGAP YESFRDMMKT
IKFSRVLARA GIDAIQISTY TPLPGTRIFL DALRKNEIFT LDWSRYDILT PVAKTRVNPA
IIQALTAYGY YSFYAYKWLH DRLHEVRAVG FKDQIMMNAQ KFIMRMMPSY IKDIFRLPSD
IMKTAILYRN GIRKRIATDE HVRELIADSS SIVYKETDVK NPYFKIKTQ
//