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Database: UniProt
Entry: Q9HL19_THEAC
LinkDB: Q9HL19_THEAC
Original site: Q9HL19_THEAC 
ID   Q9HL19_THEAC            Unreviewed;       647 AA.
AC   Q9HL19;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   24-JAN-2024, entry version 97.
DE   RecName: Full=acetate--CoA ligase {ECO:0000256|ARBA:ARBA00013275};
DE            EC=6.2.1.1 {ECO:0000256|ARBA:ARBA00013275};
GN   OrderedLocusNames=Ta0421 {ECO:0000313|EMBL:CAC11563.1};
OS   Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS   15155 / AMRC-C165).
OC   Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC   Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273075 {ECO:0000313|EMBL:CAC11563.1, ECO:0000313|Proteomes:UP000001024};
RN   [1] {ECO:0000313|EMBL:CAC11563.1, ECO:0000313|Proteomes:UP000001024}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165
RC   {ECO:0000313|Proteomes:UP000001024};
RX   PubMed=11029001; DOI=10.1038/35035069;
RA   Ruepp A., Graml W., Santos-Martinez M.L., Koretke K.K., Volker C.,
RA   Mewes H.W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT   "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT   acidophilum.";
RL   Nature 407:508-513(2000).
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DR   EMBL; AL445064; CAC11563.1; -; Genomic_DNA.
DR   RefSeq; WP_010900848.1; NC_002578.1.
DR   AlphaFoldDB; Q9HL19; -.
DR   STRING; 273075.gene:9571640; -.
DR   PaxDb; 273075-Ta0421; -.
DR   EnsemblBacteria; CAC11563; CAC11563; CAC11563.
DR   GeneID; 1456030; -.
DR   KEGG; tac:Ta0421; -.
DR   eggNOG; arCOG04201; Archaea.
DR   HOGENOM; CLU_000022_3_6_2; -.
DR   InParanoid; Q9HL19; -.
DR   OMA; DHWWHDL; -.
DR   OrthoDB; 371752at2157; -.
DR   Proteomes; UP000001024; Chromosome.
DR   GO; GO:0003987; F:acetate-CoA ligase activity; IEA:InterPro.
DR   GO; GO:0016208; F:AMP binding; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0019427; P:acetyl-CoA biosynthetic process from acetate; IEA:InterPro.
DR   CDD; cd05966; ACS; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   InterPro; IPR011904; Ac_CoA_lig.
DR   InterPro; IPR032387; ACAS_N.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   NCBIfam; TIGR02188; Ac_CoA_lig_AcsA; 1.
DR   PANTHER; PTHR24095; ACETYL-COENZYME A SYNTHETASE; 1.
DR   PANTHER; PTHR24095:SF14; ACETYL-COENZYME A SYNTHETASE 1; 1.
DR   Pfam; PF16177; ACAS_N; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF13193; AMP-binding_C; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Ligase {ECO:0000256|ARBA:ARBA00022598};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001024}.
FT   DOMAIN          21..75
FT                   /note="Acetyl-coenzyme A synthetase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF16177"
FT   DOMAIN          78..464
FT                   /note="AMP-dependent synthetase/ligase"
FT                   /evidence="ECO:0000259|Pfam:PF00501"
FT   DOMAIN          525..603
FT                   /note="AMP-binding enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13193"
SQ   SEQUENCE   647 AA;  72683 MW;  07913C52F3D4E8B5 CRC64;
     MESEKGTLPM NEVYNPGMNV YSEIYRKSLE DPENFWAKQA EILTWYSKWN KILDDSKKPF
     YRWFVGGKLN VSYNAVDRHL EQHRRNKAAY IWVGENGEEK IVTYDGLYRR INNLAKALLN
     LGIKKGDRIV LYLPMIIEAP VAMLAAARIG AVFSFVFAGF GAGALAERIN DSKAVLLITA
     DGGFRNGKVV ELKKIADEAL EMTSTVRNVI VIKHARNDVN MVEDRDIWYH EIVGDSHTYV
     EPEHMDANDP LFILYTSGTT GKPKGAVHST GGYSVWVAST LKWAFNPDED DRWWCAADIG
     WITGHSYIVF APLILGLTSI MYEGSITYPE PDRLWEIIEK YRVNILYTSP TAIRTLMKFG
     EKYPQRHDLS TLKVLGTVGE PINPAAWKWY YEIIGNSRCP IIDTYWQTET GGFMIAPQRG
     LGLPPLKPGS ATFPLPGVDP AILDDAGKEV RTGEKGYIVF RRPWPGMLMT VNNDDERYVK
     TYFSKFPGYY YCGDYAVKDE DGYYWLLGRS DEVMNVSGHR LGTIEIEDAI VATGLAVEAA
     VFGKPDPVKG EAISAFVVPK DANADRHELI SEIRKRIRAD LGPIYVPDEI RIVKLLPKTR
     SGKIMRRVVK AVALNQIPGD LTTLEDSTSV DEIKSAIEAF KGEAGGE
//
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