ID Q9HLD7_THEAC Unreviewed; 658 AA.
AC Q9HLD7;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE SubName: Full=L-3-hydroxyacyl-CoA dehydrogenase related protein {ECO:0000313|EMBL:CAC11436.1};
GN OrderedLocusNames=Ta0291 {ECO:0000313|EMBL:CAC11436.1};
OS Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC
OS 15155 / AMRC-C165).
OC Archaea; Candidatus Thermoplasmatota; Thermoplasmata; Thermoplasmatales;
OC Thermoplasmataceae; Thermoplasma.
OX NCBI_TaxID=273075 {ECO:0000313|EMBL:CAC11436.1, ECO:0000313|Proteomes:UP000001024};
RN [1] {ECO:0000313|EMBL:CAC11436.1, ECO:0000313|Proteomes:UP000001024}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165
RC {ECO:0000313|Proteomes:UP000001024};
RX PubMed=11029001; DOI=10.1038/35035069;
RA Ruepp A., Graml W., Santos-Martinez M.L., Koretke K.K., Volker C.,
RA Mewes H.W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT acidophilum.";
RL Nature 407:508-513(2000).
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
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DR EMBL; AL445063; CAC11436.1; -; Genomic_DNA.
DR RefSeq; WP_010900720.1; NC_002578.1.
DR AlphaFoldDB; Q9HLD7; -.
DR STRING; 273075.gene:9571508; -.
DR PaxDb; 273075-Ta0291; -.
DR EnsemblBacteria; CAC11436; CAC11436; CAC11436.
DR GeneID; 1455916; -.
DR KEGG; tac:Ta0291; -.
DR eggNOG; arCOG00249; Archaea.
DR HOGENOM; CLU_010448_2_0_2; -.
DR InParanoid; Q9HLD7; -.
DR OrthoDB; 39812at2157; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000001024; Chromosome.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.12.10; Lyase 2-enoyl-coa Hydratase, Chain A, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR014748; Enoyl-CoA_hydra_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR23309; 3-HYDROXYACYL-COA DEHYROGENASE; 1.
DR PANTHER; PTHR23309:SF9; PEROXISOMAL BIFUNCTIONAL ENZYME; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000001024}.
FT DOMAIN 5..183
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 186..280
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 303..369
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 658 AA; 72229 MW; DE80E3FABBA2ACF8 CRC64;
MEINKVTVIG SGIMGHGIAE VIALAGIDVN IEDISNEVLD KAKASINSSL DRLVSSGKLK
NKDEVLSRIH YFTDIPSSVK DADLVIEAVP EVLDIKKSVF DQLDKSTKDS AILATNTSNI
RLTEIAEGIK KKGKVVGMHF FNPPVVLKLV EVIRSQYTED EVFETVYEFS KRIGKTPIKV
YKDTPGFVVN RINAPESLYF CLVIDNNLAK PEEVDRFARS QGLPMGPYEL MDYVGIDTVY
HSLQYYAKEL SPDYSKCQVY TKLFNEKKLG LKTGEGFYKW VNGKAQIPEA KPTKAVELMD
IFALEINEAV KIIEDGVASP DDIETGVKLG MNRPFGPITV AKGLTNAEVK AKLEALYQKF
SVEVFKPAKS IAEGKLKTVI SMQVALSKAE EKKEAASAYI SSSDPVIMET KGRIAILRIN
NTKNNLINAA VMDGLEKALT DLWNNREISV IVLTGNGPVF SAGAQLDSFF SSTFDFMEFS
RRGERVFKLL SEIPKVTIAE LKGYTLGGGF EMALACDIRV ATEDVQIGFP EVTLGLVPGW
GGTQRLSRTA GQSRAAYYIL TGERFTGKEA YEMGIVAKIF SKDTIDSETL NLAQNIADKV
APISAALAKR LVLRSTNTSL DDGLEMEAIS MGLLYGTEDL KEGISAFLGK RKPNYQGK
//
