GenomeNet

Database: UniProt
Entry: Q9HM14
LinkDB: Q9HM14
Original site: Q9HM14 
ID   XPD_THEAC               Reviewed;         602 AA.
AC   Q9HM14;
DT   14-OCT-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   16-OCT-2019, entry version 93.
DE   RecName: Full=ATP-dependent DNA helicase Ta0057;
DE            EC=3.6.4.12;
GN   OrderedLocusNames=Ta0057;
OS   Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 /
OS   NBRC 15155 / AMRC-C165).
OC   Archaea; Euryarchaeota; Diaforarchaea group; Thermoplasmata;
OC   Thermoplasmatales; Thermoplasmataceae; Thermoplasma.
OX   NCBI_TaxID=273075;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165;
RX   PubMed=11029001; DOI=10.1038/35035069;
RA   Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C.,
RA   Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.;
RT   "The genome sequence of the thermoacidophilic scavenger Thermoplasma
RT   acidophilum.";
RL   Nature 407:508-513(2000).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS), AND IRON-SULFUR CLUSTER.
RX   PubMed=18578568; DOI=10.1371/journal.pbio.0060149;
RA   Wolski S.C., Kuper J., Hanzelmann P., Truglio J.J., Croteau D.L.,
RA   Van Houten B., Kisker C.;
RT   "Crystal structure of the FeS cluster-containing nucleotide excision
RT   repair helicase XPD.";
RL   PLoS Biol. 6:E149-E149(2008).
CC   -!- FUNCTION: ATP-dependent 5'-3' DNA helicase involved in nucleotide
CC       excision repair (NER) of DNA. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC       Note=Binds 1 [4Fe-4S] cluster.;
CC   -!- SIMILARITY: Belongs to the helicase family. RAD3/XPD subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAC11205.1; Type=Erroneous initiation; Evidence={ECO:0000305};
DR   EMBL; AL445063; CAC11205.1; ALT_INIT; Genomic_DNA.
DR   PDB; 2VSF; X-ray; 2.90 A; A=1-602.
DR   PDB; 4A15; X-ray; 2.20 A; A=2-602.
DR   PDB; 5H8W; X-ray; 2.20 A; A=1-597.
DR   PDBsum; 2VSF; -.
DR   PDBsum; 4A15; -.
DR   PDBsum; 5H8W; -.
DR   SMR; Q9HM14; -.
DR   STRING; 273075.Ta0057m; -.
DR   EnsemblBacteria; CAC11205; CAC11205; CAC11205.
DR   KEGG; tac:Ta0057; -.
DR   eggNOG; arCOG00770; Archaea.
DR   eggNOG; COG1199; LUCA.
DR   KO; K10844; -.
DR   OMA; PYFTARR; -.
DR   EvolutionaryTrace; Q9HM14; -.
DR   Proteomes; UP000001024; Chromosome.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.30.20; -; 1.
DR   InterPro; IPR006555; ATP-dep_Helicase_C.
DR   InterPro; IPR010614; DEAD_2.
DR   InterPro; IPR010643; HBB.
DR   InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR   InterPro; IPR006554; Helicase-like_DEXD_c2.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR042493; XPD_DNA_FeS.
DR   Pfam; PF06733; DEAD_2; 1.
DR   Pfam; PF06777; HBB; 1.
DR   Pfam; PF13307; Helicase_C_2; 1.
DR   SMART; SM00488; DEXDc2; 1.
DR   SMART; SM00491; HELICc2; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   1: Evidence at protein level;
KW   3D-structure; 4Fe-4S; ATP-binding; Complete proteome; DNA damage;
KW   DNA repair; DNA-binding; Helicase; Hydrolase; Iron; Iron-sulfur;
KW   Metal-binding; Nucleotide-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN         1    602       ATP-dependent DNA helicase Ta0057.
FT                                /FTId=PRO_0000352310.
FT   DOMAIN        1    247       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      421    602       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND      11     18       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       193    196       DEAH box.
FT   METAL        74     74       Iron-sulfur (4Fe-4S).
FT   METAL        95     95       Iron-sulfur (4Fe-4S).
FT   METAL       110    110       Iron-sulfur (4Fe-4S).
FT   METAL       146    146       Iron-sulfur (4Fe-4S).
FT   STRAND        4     10       {ECO:0000244|PDB:4A15}.
FT   STRAND       13     16       {ECO:0000244|PDB:2VSF}.
FT   HELIX        17     32       {ECO:0000244|PDB:4A15}.
FT   STRAND       35     42       {ECO:0000244|PDB:4A15}.
FT   HELIX        43     59       {ECO:0000244|PDB:4A15}.
FT   STRAND       64     66       {ECO:0000244|PDB:4A15}.
FT   HELIX        70     73       {ECO:0000244|PDB:4A15}.
FT   HELIX        77     80       {ECO:0000244|PDB:4A15}.
FT   HELIX        88    103       {ECO:0000244|PDB:4A15}.
FT   HELIX       107    109       {ECO:0000244|PDB:2VSF}.
FT   HELIX       115    118       {ECO:0000244|PDB:4A15}.
FT   HELIX       120    129       {ECO:0000244|PDB:4A15}.
FT   HELIX       133    142       {ECO:0000244|PDB:4A15}.
FT   HELIX       147    154       {ECO:0000244|PDB:4A15}.
FT   HELIX       155    157       {ECO:0000244|PDB:4A15}.
FT   STRAND      159    164       {ECO:0000244|PDB:4A15}.
FT   HELIX       165    168       {ECO:0000244|PDB:4A15}.
FT   HELIX       171    181       {ECO:0000244|PDB:4A15}.
FT   HELIX       185    187       {ECO:0000244|PDB:4A15}.
FT   STRAND      188    192       {ECO:0000244|PDB:4A15}.
FT   HELIX       195    197       {ECO:0000244|PDB:4A15}.
FT   HELIX       198    206       {ECO:0000244|PDB:4A15}.
FT   STRAND      208    211       {ECO:0000244|PDB:4A15}.
FT   HELIX       212    224       {ECO:0000244|PDB:4A15}.
FT   STRAND      229    231       {ECO:0000244|PDB:4A15}.
FT   HELIX       236    254       {ECO:0000244|PDB:4A15}.
FT   STRAND      256    258       {ECO:0000244|PDB:4A15}.
FT   STRAND      260    262       {ECO:0000244|PDB:4A15}.
FT   HELIX       265    275       {ECO:0000244|PDB:4A15}.
FT   HELIX       279    302       {ECO:0000244|PDB:4A15}.
FT   HELIX       310    322       {ECO:0000244|PDB:4A15}.
FT   TURN        326    328       {ECO:0000244|PDB:4A15}.
FT   STRAND      329    334       {ECO:0000244|PDB:4A15}.
FT   HELIX       336    338       {ECO:0000244|PDB:4A15}.
FT   STRAND      340    345       {ECO:0000244|PDB:4A15}.
FT   HELIX       349    352       {ECO:0000244|PDB:4A15}.
FT   HELIX       353    357       {ECO:0000244|PDB:4A15}.
FT   STRAND      358    366       {ECO:0000244|PDB:4A15}.
FT   HELIX       370    377       {ECO:0000244|PDB:4A15}.
FT   STRAND      383    385       {ECO:0000244|PDB:4A15}.
FT   HELIX       392    394       {ECO:0000244|PDB:4A15}.
FT   STRAND      395    400       {ECO:0000244|PDB:4A15}.
FT   HELIX       407    409       {ECO:0000244|PDB:5H8W}.
FT   HELIX       412    429       {ECO:0000244|PDB:4A15}.
FT   STRAND      433    438       {ECO:0000244|PDB:4A15}.
FT   HELIX       440    446       {ECO:0000244|PDB:4A15}.
FT   HELIX       464    473       {ECO:0000244|PDB:4A15}.
FT   STRAND      479    483       {ECO:0000244|PDB:4A15}.
FT   STRAND      489    491       {ECO:0000244|PDB:5H8W}.
FT   HELIX       496    498       {ECO:0000244|PDB:5H8W}.
FT   STRAND      501    506       {ECO:0000244|PDB:4A15}.
FT   HELIX       514    527       {ECO:0000244|PDB:4A15}.
FT   HELIX       530    534       {ECO:0000244|PDB:4A15}.
FT   HELIX       536    548       {ECO:0000244|PDB:4A15}.
FT   STRAND      553    555       {ECO:0000244|PDB:2VSF}.
FT   STRAND      558    563       {ECO:0000244|PDB:4A15}.
FT   HELIX       565    573       {ECO:0000244|PDB:4A15}.
FT   STRAND      578    581       {ECO:0000244|PDB:4A15}.
FT   HELIX       583    595       {ECO:0000244|PDB:4A15}.
SQ   SEQUENCE   602 AA;  69169 MW;  CE13FA7D1F3A0DD8 CRC64;
     MQKSYGVALE SPTGSGKTIM ALKSALQYSS ERKLKVLYLV RTNSQEEQVI KELRSLSSTM
     KIRAIPMQGR VNMCILYRMV DDLHEINAES LAKFCNMKKR EVMAGNEAAC PYFNFKIRSD
     ETKRFLFDEL PTAEEFYDYG ERNNVCPYES MKAALPDADI VIAPYAYFLN RSVAEKFLSH
     WGVSRNQIVI ILDEAHNLPD IGRSIGSFRI SVESLNRADR EAQAYGDPEL SQKIHVSDLI
     EMIRSALQSM VSERCGKGDV RIRFQEFMEY MRIMNKRSER EIRSLLNYLY LFGEYVENEK
     EKVGKVPFSY CSSVASRIIA FSDQDEEKYA AILSPEDGGY MQAACLDPSG ILEVLKESKT
     IHMSGTLDPF DFYSDITGFE IPFKKIGEIF PPENRYIAYY DGVSSKYDTL DEKELDRMAT
     VIEDIILKVK KNTIVYFPSY SLMDRVENRV SFEHMKEYRG IDQKELYSML KKFRRDHGTI
     FAVSGGRLSE GINFPGNELE MIILAGLPFP RPDAINRSLF DYYERKYGKG WEYSVVYPTA
     IKIRQEIGRL IRSAEDTGAC VILDKRAGQF RKFIPDMKKT SDPASDIYNF FISAQAREKY
     GA
//
DBGET integrated database retrieval system