ID Q9HSH6_HALSA Unreviewed; 356 AA.
AC Q9HSH6;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE SubName: Full=Probable periplasmic serine protease {ECO:0000313|EMBL:DAC77516.1};
DE EC=3.4.21.- {ECO:0000313|EMBL:DAC77516.1};
DE SubName: Full=Serine proteinase {ECO:0000313|EMBL:AAG18830.1};
GN Name=htrA {ECO:0000313|EMBL:AAG18830.1};
GN Synonyms=degP {ECO:0000313|EMBL:DAC77516.1};
GN OrderedLocusNames=VNG_0226G {ECO:0000313|EMBL:AAG18830.1};
OS Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS (Halobacterium halobium).
OC Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC Halobacteriaceae; Halobacterium; Halobacterium salinarum NRC-34001.
OX NCBI_TaxID=64091 {ECO:0000313|EMBL:AAG18830.1, ECO:0000313|Proteomes:UP000000554};
RN [1] {ECO:0000313|EMBL:AAG18830.1, ECO:0000313|Proteomes:UP000000554}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700922 / JCM 11081 / NRC-1
RC {ECO:0000313|Proteomes:UP000000554}, and NRC-1
RC {ECO:0000313|EMBL:AAG18830.1};
RX PubMed=11016950; DOI=10.1073/pnas.190337797;
RA Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA Spudich J.L., Jung K.W., Alam M., Freitas T., Hou S., Daniels C.J.,
RA Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA DasSarma S.;
RT "Genome sequence of Halobacterium species NRC-1.";
RL Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN [2] {ECO:0000313|EMBL:DAC77516.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRC-1 {ECO:0000313|EMBL:DAC77516.1};
RX PubMed=18313895; DOI=.1016/j.ygeno.2008.01.001;
RA Pfeiffer F., Schuster S.C., Broicher A., Falb M., Palm P., Rodewald K.,
RA Ruepp A., Soppa J., Tittor J., Oesterhelt D.;
RT "Evolution in the laboratory: the genome of Halobacterium salinarum strain
RT R1 compared to that of strain NRC-1.";
RL Genomics 91:335-346(2008).
RN [3] {ECO:0000313|EMBL:DAC77516.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRC-1 {ECO:0000313|EMBL:DAC77516.1};
RX PubMed=26042526;
RA Pfeiffer F., Oesterhelt D.;
RT "A manual curation strategy to improve genome annotation: application to a
RT set of haloarchael genomes.";
RL Life 5:1427-1444(2015).
RN [4] {ECO:0000313|EMBL:DAC77516.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NRC-1 {ECO:0000313|EMBL:DAC77516.1};
RA Pfeiffer F., Marchfelder A., Habermann B.H., Dyall-Smith M.;
RT "The genome of the Halobacterium salinarum type strain is closely related
RT to that of the laboratory strains NRC-1 and R1.";
RL Microbiol. Resour. Announc. 0:0-0(2019).
CC -!- SIMILARITY: Belongs to the peptidase S1C family.
CC {ECO:0000256|ARBA:ARBA00010541}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE004437; AAG18830.1; -; Genomic_DNA.
DR EMBL; BK010829; DAC77516.1; -; Genomic_DNA.
DR PIR; B84183; B84183.
DR RefSeq; WP_010902123.1; NC_002607.1.
DR AlphaFoldDB; Q9HSH6; -.
DR STRING; 64091.VNG_0226G; -.
DR PaxDb; 64091-VNG_0226G; -.
DR GeneID; 5954416; -.
DR KEGG; hal:VNG_0226G; -.
DR PATRIC; fig|64091.14.peg.163; -.
DR HOGENOM; CLU_020120_2_2_2; -.
DR OrthoDB; 350578at2157; -.
DR Proteomes; UP000000554; Chromosome.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00987; PDZ_serine_protease; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 2.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001940; Peptidase_S1C.
DR InterPro; IPR006311; TAT_signal.
DR InterPro; IPR028301; V8_his_AS.
DR PANTHER; PTHR43343; PEPTIDASE S12; 1.
DR PANTHER; PTHR43343:SF3; PROTEASE DO-LIKE 8, CHLOROPLASTIC; 1.
DR Pfam; PF13180; PDZ_2; 1.
DR Pfam; PF13365; Trypsin_2; 1.
DR PRINTS; PR00834; PROTEASES2C.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
DR PROSITE; PS51318; TAT; 1.
DR PROSITE; PS00672; V8_HIS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:DAC77516.1};
KW Protease {ECO:0000313|EMBL:DAC77516.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000554}.
FT DOMAIN 245..350
FT /note="PDZ"
FT /evidence="ECO:0000259|Pfam:PF13180"
SQ SEQUENCE 356 AA; 36243 MW; 3C450337D19BF9DA CRC64;
MPSRRDVLRL GAGVLAAGTA GCTDTAPNRV AAAETAATTT RETTTDSRSE SPYTAVYRDV
IDSVVMIRTQ SGQGTGWLYN DTTLVTNAHV VGRSETVNVR FNDGTWETGR VRGTDPNSDL
AAVTVTDTPA AATPLALRTA SPVAGTEVVA IGNPFALNGT VTTGIISGTN RAIPAPTGYR
IPDAVQTDAA VNPGNSGGPL VSLDGDVVAV VNSGGGDNIA FGISAALTDR VVPSLIDTGD
YEHAYLGVSF TPVTPTVADA NGLTESRGLL VMSVDPSGPS AGRLVGSDAT TIVDGGAVRV
GGDIVLAVNG TRVHTLEDVL SLLALHTSPG DTVSVRLLRD GDRRTVDVEL GARPSG
//
