ID   Q9HUE4_PSEAE            Unreviewed;       425 AA.
AC   Q9HUE4;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   27-MAR-2024, entry version 116.
DE   SubName: Full=Homocysteine synthase {ECO:0000313|EMBL:AAG08410.1};
GN   Name=metY {ECO:0000313|EMBL:AAG08410.1};
GN   OrderedLocusNames=PA5025 {ECO:0000313|EMBL:AAG08410.1};
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964 {ECO:0000313|EMBL:AAG08410.1, ECO:0000313|Proteomes:UP000002438};
RN   [1] {ECO:0000313|EMBL:AAG08410.1, ECO:0000313|Proteomes:UP000002438}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC   1C / PRS 101 / PAO1 {ECO:0000313|Proteomes:UP000002438};
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.Q., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R., Smith K.,
RA   Spencer D., Wong G.K., Wu Z., Paulsen I.T., Reizer J., Saier M.H.,
RA   Hancock R.E., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU362118};
CC   -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC       {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR   EMBL; AE004091; AAG08410.1; -; Genomic_DNA.
DR   PIR; E83018; E83018.
DR   RefSeq; NP_253712.1; NC_002516.2.
DR   RefSeq; WP_003114564.1; NZ_QZGE01000002.1.
DR   AlphaFoldDB; Q9HUE4; -.
DR   SMR; Q9HUE4; -.
DR   STRING; 208964.PA5025; -.
DR   PaxDb; 208964-PA5025; -.
DR   GeneID; 881205; -.
DR   KEGG; pae:PA5025; -.
DR   PATRIC; fig|208964.12.peg.5268; -.
DR   PseudoCAP; PA5025; -.
DR   HOGENOM; CLU_018986_4_0_6; -.
DR   InParanoid; Q9HUE4; -.
DR   OrthoDB; 9805807at2; -.
DR   PhylomeDB; Q9HUE4; -.
DR   BioCyc; PAER208964:G1FZ6-5141-MONOMER; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
DR   GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR   CDD; cd00614; CGS_like; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR   InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR   PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR   PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR   Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR   PIRSF; PIRSF001434; CGS; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE   3: Inferred from homology;
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|PIRSR:PIRSR001434-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002438}.
FT   MOD_RES         204
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ   SEQUENCE   425 AA;  45178 MW;  88A38689E0575B09 CRC64;
     MKLETLAVHA GYSPDPTTRA VAVPIYQTTS YAFDDTQHGA DLFDLKVPGN IYTRIMNPTN
     DVLEQRVAAL EGGVGALAVA SGMAAITYAI QTVAEAGDNI VSVAKLYGGT YNLLAHTLPR
     IGIQARFAAH DDVAALEALI DERTKAVFCE TIGNPAGNII DLQALADAAH RHGVPLIVDN
     TVATPVLCRP FEHGADIVVH SLTKYMGGHG TSIGGIVVDS GKFDWAANKS RFPLLNTPDP
     SYHGVTYTEA FGPAAFIGRC RVVPLRNMGA ALSPFNAFLI LQGLETLALR MERHCDNALA
     VARYLQQHPQ VAWVKYAGLA DNPEHALARR YLGGRPAAIL SFGIQGGSAA GARFIDALKL
     VVRLVNIGDA KSLACHPAST THRQLNAEEL ARAGVSDDMV RLSIGIEHID DILADLDQAL
     AAAAR
//