ID Q9HWZ1_PSEAE Unreviewed; 766 AA.
AC Q9HWZ1;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 143.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN OrderedLocusNames=PA4036 {ECO:0000313|EMBL:AAG07423.1};
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964 {ECO:0000313|EMBL:AAG07423.1, ECO:0000313|Proteomes:UP000002438};
RN [1] {ECO:0000313|EMBL:AAG07423.1, ECO:0000313|Proteomes:UP000002438}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC 1C / PRS 101 / PAO1 {ECO:0000313|Proteomes:UP000002438};
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.Q., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R., Smith K.,
RA Spencer D., Wong G.K., Wu Z., Paulsen I.T., Reizer J., Saier M.H.,
RA Hancock R.E., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; AE004091; AAG07423.1; -; Genomic_DNA.
DR PIR; H83141; H83141.
DR RefSeq; NP_252725.1; NC_002516.2.
DR RefSeq; WP_003114910.1; NZ_QZGE01000013.1.
DR AlphaFoldDB; Q9HWZ1; -.
DR SMR; Q9HWZ1; -.
DR STRING; 208964.PA4036; -.
DR PaxDb; 208964-PA4036; -.
DR GeneID; 879031; -.
DR KEGG; pae:PA4036; -.
DR PATRIC; fig|208964.12.peg.4227; -.
DR PseudoCAP; PA4036; -.
DR HOGENOM; CLU_016084_0_0_6; -.
DR InParanoid; Q9HWZ1; -.
DR OrthoDB; 9806704at2; -.
DR PhylomeDB; Q9HWZ1; -.
DR BioCyc; PAER208964:G1FZ6-4109-MONOMER; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009927; F:histidine phosphotransfer kinase activity; IBA:GO_Central.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IBA:GO_Central.
DR CDD; cd00075; HATPase; 1.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR007890; CHASE2.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013656; PAS_4.
DR InterPro; IPR004358; Sig_transdc_His_kin-like_C.
DR InterPro; IPR017181; Sig_transdc_His_kin_CHASE2.
DR PANTHER; PTHR43047:SF72; OSMOSENSING HISTIDINE PROTEIN KINASE SLN1; 1.
DR PANTHER; PTHR43047; TWO-COMPONENT HISTIDINE PROTEIN KINASE; 1.
DR Pfam; PF05226; CHASE2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF08448; PAS_4; 1.
DR PIRSF; PIRSF037347; STHK_CHASE2_PAS_prd; 1.
DR PRINTS; PR00344; BCTRLSENSOR.
DR SMART; SM01080; CHASE2; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00091; PAS; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000002438};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 309..328
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 333..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 357..374
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 552..763
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
SQ SEQUENCE 766 AA; 84132 MW; 930F4109A7F8CFDA CRC64;
MKALDRQDEP SQAQRLFRGL VREWLLVSLL LLPLTALLSL SSGLPLNNLL YDRLRNLAPL
AVDPRILVVA IDDRSLESLG RWPWPRSVHA ELLDRLAAAG ARSVLLDVIF SEPSSNPDSD
RQLARSLCRA GNVLLPLLRE SVPRYGEPPR EIPPTAPLAG CAAGIGHINV EADSDGTVRS
VYLREGPLGQ PRPLLAWQAF ADAGAMPMPG LDDMRNLPGW QRDHAIRIPF IGADAGFPSV
PYVSVLRGEV PDSLLRDRLV LVGATAPGLG DRYVTPLSAS LGTTPGVEIQ ANILNGLLQQ
RTAVDLQPWL AALLSAASVA LLLGLMLFRS RHALLLTLAC AALALGLSWA LLLNGWWWSP
LASLVGLLLA YLIWSWRRLN AVLAYFGWEL ARLDREPKVL PERASPPRAG NDPLQNRIAA
LEQAVSRTRD SRRFMADGLE GLPVATLICD PQGQILLANR KARDLFGGEL RGAELRQRLA
ELGHPSLAGG ARPTLETLEA IEFRDHRERD LRLDLARLLP VESETAIGWL VSLIDLSAER
DAERQRATLL RFLSHDLRAP HSAILALLDV RPAEDEAGQQ VYRQIEQQVR RALGLTDAFV
QLAKAESDAY RFEACMFTML AMDAADQLWP LAQQKDIDLR RDWDDEQEPM VWADPGLLTR
ALFNLLENAV KYSPAGTVVS LSIRLEGDWL SCRIVDQGKG IAAAELPRLF SQYQRFASAE
GSAGLGLGLA MVKTVIDRHG GRIGCQSQVG QGTTFEIRLP LLKGEE
//
