ID Q9I1A8_PSEAE Unreviewed; 849 AA.
AC Q9I1A8;
DT 01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2001, sequence version 1.
DT 27-MAR-2024, entry version 131.
DE SubName: Full=Probable ClpA/B-type protease {ECO:0000313|EMBL:AAG05759.1};
GN OrderedLocusNames=PA2371 {ECO:0000313|EMBL:AAG05759.1};
OS Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=208964 {ECO:0000313|EMBL:AAG05759.1, ECO:0000313|Proteomes:UP000002438};
RN [1] {ECO:0000313|EMBL:AAG05759.1, ECO:0000313|Proteomes:UP000002438}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
RC 1C / PRS 101 / PAO1 {ECO:0000313|Proteomes:UP000002438};
RX PubMed=10984043; DOI=10.1038/35023079;
RA Stover C.K., Pham X.Q., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA Hickey M.J., Brinkman F.S., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R., Smith K.,
RA Spencer D., Wong G.K., Wu Z., Paulsen I.T., Reizer J., Saier M.H.,
RA Hancock R.E., Lory S., Olson M.V.;
RT "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT pathogen.";
RL Nature 406:959-964(2000).
CC -!- SIMILARITY: Belongs to the ClpA/ClpB family.
CC {ECO:0000256|ARBA:ARBA00008675}.
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DR EMBL; AE004091; AAG05759.1; -; Genomic_DNA.
DR PIR; E83349; E83349.
DR RefSeq; NP_251061.1; NC_002516.2.
DR RefSeq; WP_003114516.1; NZ_QZGE01000021.1.
DR AlphaFoldDB; Q9I1A8; -.
DR SMR; Q9I1A8; -.
DR STRING; 208964.PA2371; -.
DR PaxDb; 208964-PA2371; -.
DR GeneID; 877948; -.
DR KEGG; pae:PA2371; -.
DR PATRIC; fig|208964.12.peg.2482; -.
DR PseudoCAP; PA2371; -.
DR HOGENOM; CLU_005070_4_0_6; -.
DR InParanoid; Q9I1A8; -.
DR OrthoDB; 9803641at2; -.
DR PhylomeDB; Q9I1A8; -.
DR BioCyc; PAER208964:G1FZ6-2410-MONOMER; -.
DR Proteomes; UP000002438; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0034605; P:cellular response to heat; IBA:GO_Central.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd19499; RecA-like_ClpB_Hsp104-like; 1.
DR Gene3D; 1.10.1780.10; Clp, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR017729; ATPase_T6SS_ClpV1.
DR InterPro; IPR019489; Clp_ATPase_C.
DR InterPro; IPR036628; Clp_N_dom_sf.
DR InterPro; IPR004176; Clp_R_dom.
DR InterPro; IPR001270; ClpA/B.
DR InterPro; IPR018368; ClpA/B_CS1.
DR InterPro; IPR041546; ClpA/ClpB_AAA_lid.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR03345; VI_ClpV1; 1.
DR PANTHER; PTHR11638; ATP-DEPENDENT CLP PROTEASE; 1.
DR PANTHER; PTHR11638:SF184; ATPASE WITH CHAPERONE ACTIVITY-RELATED; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF07724; AAA_2; 1.
DR Pfam; PF17871; AAA_lid_9; 1.
DR Pfam; PF02861; Clp_N; 1.
DR Pfam; PF10431; ClpB_D2-small; 1.
DR PRINTS; PR00300; CLPPROTEASEA.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF81923; Double Clp-N motif; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00870; CLPAB_1; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Hydrolase {ECO:0000313|EMBL:AAG05759.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protease {ECO:0000313|EMBL:AAG05759.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002438};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 215..360
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 612..754
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 155..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 849 AA; 92425 MW; 79C8F4D20F464416 CRC64;
MELAALIGRL NPDCRRALER AAQRCLQRTH HYVEIEHLLL ELLDIDGGDF ACLLPRFGLE
RDALVAEINL SLELFKAGNT RTPALSAHTI GLLEDAVVHA SVLGQAQIRS GLLLLALLDR
EERRALLLNS ASSLLRIPHE ALQANLLEWI QASREQPPAP NRPAAGGDKP ESAPDPLLDQ
YTQDLTAEAR AGRIDPIVGR DGEIRQCVDI LLRRRQNNPI LVGAPGVGKT AVVEGLALRI
AAGEVPPSLQ EVILRVLDLG LLQAGASMKG EFEQRLKGVI DAVRNSAQPI ILFIDEAHTL
IGAGGAEGGS DAANLLKPAL ARGELRTLAA TTWLEYKKYF EKDPALTRRF QLVQVEEPDE
ATAVEMLRGV AGKLELHHGV QIMDAAIVDA VKLSHRYISG RQLPDKAISV LDTACARVAL
GQHDVPPPLE SLRHREQALE EELQRLRREQ ATGLDHSARI TALESESGDN RRTIRELETR
WDEEREAVRE LLDIRRELLA LSESADAAKP DEELDGRIDH LAAELARLAA GLEAIRQDDP
LVPEQVDSRT VAAVIAGWTG IPVGKMLADE AHAIRSLAQR MGQRVMGQEA ALGAIAQRIQ
AYRAGLSDPA KPVGVFLLPG PTGVGKTETA YALADALYGG ERNLISINLS EYQEAHTVSQ
LKGAPPGYVG YGSGGVLTEA VRRKPYSVVL LDEIEKAHPD VLEAFYNVFD KGVMEDGTGL
VVDFRNTVIL ATSNVGAELL LDSPAEQVAT PAFDERLRKV LLQTFRPAFL ARMTVVPYRP
LEEATLEGIV VAKLEKLRER YKAATGKQFD FDPAIVKAVL AKCSAAGARD IENVLMAQVT
GKLAEWVLE
//
