ID   SPIB_PALPA              Reviewed;         265 AA.
AC   Q9I8M6;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   22-FEB-2023, entry version 73.
DE   RecName: Full=Transcription factor Spi-B-like;
OS   Paleosuchus palpebrosus (Cuvier's smooth-fronted caiman) (Dwarf caiman).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Crocodylia; Alligatoridae; Caimaninae;
OC   Paleosuchus.
OX   NCBI_TaxID=84099;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10840049; DOI=10.1073/pnas.110505597;
RA   Shintani S., Terzic J., Sato A., Saraga-Babic M., O'hUigin C., Tichy H.,
RA   Klein J.;
RT   "Do lampreys have lymphocytes? The Spi evidence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:7417-7422(2000).
CC   -!- FUNCTION: May act as a sequence specific transcriptional activator.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
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DR   EMBL; AF247364; AAF78906.1; -; mRNA.
DR   AlphaFoldDB; Q9I8M6; -.
DR   SMR; Q9I8M6; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR046328; ETS_fam.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11849; ETS; 1.
DR   PANTHER; PTHR11849:SF174; TRANSCRIPTION FACTOR SPI-B; 1.
DR   Pfam; PF00178; Ets; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..265
FT                   /note="Transcription factor Spi-B-like"
FT                   /id="PRO_0000204139"
FT   DNA_BIND        169..252
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT   REGION          1..31
FT                   /note="TAD1 (Acidic)"
FT   REGION          42..63
FT                   /note="TAD2"
FT   REGION          127..160
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   265 AA;  29313 MW;  2E6142E476E6AC82 CRC64;
     MLTLEASQLD GPHPSYMFSD SSFYDLDSCK PLPTFPHCLM EAEPPTDPCA GWLELAEPGY
     EPFDSGQLAP LHTVTVPYGH GPYPPAPSDA IYSLEGPLPA PSHCPVLPEE YGAQPYTLYS
     PCPLPSTPLS EDDDFPTDAP ALEVSDSDSD ENLSPGGSLD LDSGSRRKLR LYQFLLGLLQ
     RGDMQECVWW VEHDSGVFQF SSKHKEALAH RWGQQKGNRK AMTYQKMARA LRNYGKTGEI
     RKVKKKLTYQ FGHKLLGLSG PRAPS
//