ID OTOR_CHICK Reviewed; 132 AA.
AC Q9I8P6;
DT 21-FEB-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 24-JAN-2024, entry version 108.
DE RecName: Full=Otoraplin;
DE Flags: Precursor;
GN Name=OTOR;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10873378; DOI=10.1006/geno.2000.6224;
RA Robertson N.G., Heller S., Lin J.S., Resendes B.L., Weremowicz S.,
RA Denis C.S., Bell A.M., Hudspeth A.J., Morton C.C.;
RT "A novel conserved cochlear gene, OTOR: identification, expression
RT analysis, and chromosomal mapping.";
RL Genomics 66:242-248(2000).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Highly expressed in cochlea.
CC -!- SIMILARITY: Belongs to the MIA/OTOR family. {ECO:0000305}.
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DR EMBL; AF233518; AAF82727.1; -; mRNA.
DR RefSeq; NP_990063.1; NM_204732.1.
DR AlphaFoldDB; Q9I8P6; -.
DR SMR; Q9I8P6; -.
DR STRING; 9031.ENSGALP00000014195; -.
DR PaxDb; 9031-ENSGALP00000014195; -.
DR Ensembl; ENSGALT00000014211; ENSGALP00000014195; ENSGALG00000008732.
DR Ensembl; ENSGALT00010046607.1; ENSGALP00010027758.1; ENSGALG00010019275.1.
DR Ensembl; ENSGALT00015049168; ENSGALP00015028613; ENSGALG00015020133.
DR GeneID; 395484; -.
DR KEGG; gga:395484; -.
DR CTD; 64693; -.
DR VEuPathDB; HostDB:geneid_395484; -.
DR eggNOG; ENOG502S18Q; Eukaryota.
DR GeneTree; ENSGT00950000182767; -.
DR HOGENOM; CLU_158739_0_1_1; -.
DR InParanoid; Q9I8P6; -.
DR OMA; LCADDDC; -.
DR OrthoDB; 5342070at2759; -.
DR PhylomeDB; Q9I8P6; -.
DR TreeFam; TF332724; -.
DR PRO; PR:Q9I8P6; -.
DR Proteomes; UP000000539; Chromosome 3.
DR Bgee; ENSGALG00000008732; Expressed in skeletal muscle tissue and 5 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0001502; P:cartilage condensation; IBA:GO_Central.
DR CDD; cd11891; MIAL; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR042801; OTOR.
DR InterPro; IPR035554; Otoraplin_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR47146; OTORAPLIN; 1.
DR PANTHER; PTHR47146:SF1; OTORAPLIN; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Reference proteome; Secreted; SH3 domain; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT CHAIN 24..132
FT /note="Otoraplin"
FT /id="PRO_0000019035"
FT DOMAIN 42..114
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DISULFID 35..40
FT /evidence="ECO:0000250"
FT DISULFID 58..131
FT /evidence="ECO:0000250"
SQ SEQUENCE 132 AA; 15177 MW; 9D1CB07FD353CE1C CRC64;
MTQRVYSIVL FLCFGLMNPF ATGIFMDKLA SKKLCADDDC VYTISLVRAE EDYNAPDCRF
INIKKGQLIY VYSKLVKEKE SGEFWAGSVY GEEYEDHMGT VGYFPRSLVS EQHVYQEANK
TIPTTDIDFF CE
//
