ID RX1_PSAFA Reviewed; 334 AA.
AC Q9I9D5;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 22-FEB-2023, entry version 96.
DE RecName: Full=Retinal homeobox protein Rx1;
GN Name=rx1;
OS Psalidodon fasciatus (Banded astyanax) (Astyanax fasciatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Characiformes;
OC Characoidei; Characidae; Psalidodon.
OX NCBI_TaxID=223369;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12068949;
RA Strickler A.G., Famuditimi K., Jeffery W.R.;
RT "Retinal homeobox genes and the role of cell proliferation in cavefish eye
RT degeneration.";
RL Int. J. Dev. Biol. 46:285-294(2002).
CC -!- FUNCTION: Plays a critical role in eye formation by regulating the
CC initial specification of retinal cells and/or their subsequent
CC proliferation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000255|PROSITE-ProRule:PRU00138}.
CC -!- SIMILARITY: Belongs to the paired homeobox family. Bicoid subfamily.
CC {ECO:0000305}.
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DR EMBL; AF264703; AAF72201.1; -; mRNA.
DR AlphaFoldDB; Q9I9D5; -.
DR SMR; Q9I9D5; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR InterPro; IPR043562; RAX/RAX2.
DR PANTHER; PTHR46271; HOMEOBOX PROTEIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR46271:SF2; RETINA AND ANTERIOR NEURAL FOLD HOMEOBOX PROTEIN 2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Transcription;
KW Transcription regulation.
FT CHAIN 1..334
FT /note="Retinal homeobox protein Rx1"
FT /id="PRO_0000049282"
FT DNA_BIND 142..201
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 76..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 118..147
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 37..44
FT /note="Octapeptide motif"
FT MOTIF 311..324
FT /note="OAR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00138"
FT MOTIF 317..321
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 118..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 334 AA; 37547 MW; 4D86BDADFD0652DE CRC64;
MHLSLDTMNM VDDSCLSPGN FPEMVKGGMA AIGNRVHSID VILGFTKDQG PTLLNPGANT
LTVPQKVEVE SLGQLGKQDH PTHPYGQLPL RDSSEQPAFH GTLDTEIFSN KCESELGEVR
KVSDSDRKSP EQGDEEQPKK KHRRNRTTFT TYQLHELERA FEKSHYPDVY SREELAMKVN
LPEVRVQVWF QNRRAKWRRQ EKMDASAVKL HDSPMLSFNR PPMHTNVGPM SNSLPLDPWL
TSPLTSTTPV HSIPGFMGPS QGLQAGYPGH GFLNTPQSMG QSMQPMAPPP YQCPAVFTDK
YPLEDTNQRS SSIASLRMKA KEHIQSMDKT WQPM
//
