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Database: UniProt
Entry: Q9I9E8_DANRE
LinkDB: Q9I9E8_DANRE
Original site: Q9I9E8_DANRE 
ID   Q9I9E8_DANRE            Unreviewed;       455 AA.
AC   Q9I9E8;
DT   01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2000, sequence version 1.
DT   16-OCT-2019, entry version 163.
DE   SubName: Full=E4tf1-60 transcription factor {ECO:0000313|EMBL:AAF71747.1};
DE   SubName: Full=GA-binding protein transcription factor subunit alpha {ECO:0000313|Ensembl:ENSDARP00000091473};
DE   SubName: Full=GA-binding protein transcription factor, alpha subunit {ECO:0000313|EMBL:AAH66501.1};
DE   SubName: Full=Gabpa protein {ECO:0000313|EMBL:AAH55494.1};
GN   Name=gabpa {ECO:0000313|EMBL:AAH55494.1,
GN   ECO:0000313|Ensembl:ENSDARP00000091473,
GN   ECO:0000313|ZFIN:ZDB-GENE-011010-2};
GN   Synonyms=e4tf {ECO:0000313|EMBL:AAF71747.1,
GN   ECO:0000313|ZFIN:ZDB-GENE-011010-2};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|EMBL:AAF71747.1};
RN   [1] {ECO:0000313|EMBL:AAF71747.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Slavov D.B., Gardiner K.;
RT   "An e4tf cDNA from Zebrafish (Danio rerio).";
RL   Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAH55494.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney {ECO:0000313|EMBL:AAH66501.1}, PCR rescue
RC   {ECO:0000313|EMBL:AAI65340.1}, and Whole body
RC   {ECO:0000313|EMBL:AAH55494.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSDARP00000091473}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000091473};
RG   Ensembl;
RL   Submitted (FEB-2012) to UniProtKB.
RN   [4] {ECO:0000313|Ensembl:ENSDARP00000091473, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000091473,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [5] {ECO:0000313|Ensembl:ENSDARP00000150776}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000150776};
RG   Ensembl;
RL   Submitted (APR-2018) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004019,
CC       ECO:0000256|SAAS:SAAS00594387}.
CC   -!- SIMILARITY: Belongs to the ETS family.
CC       {ECO:0000256|RuleBase:RU004019, ECO:0000256|SAAS:SAAS00594391}.
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DR   EMBL; CR759841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AF257741; AAF71747.1; -; mRNA.
DR   EMBL; BC055494; AAH55494.1; -; mRNA.
DR   EMBL; BC066501; AAH66501.1; -; mRNA.
DR   EMBL; BC165340; AAI65340.1; -; mRNA.
DR   RefSeq; NP_001315341.1; NM_001328412.1.
DR   RefSeq; NP_571662.1; NM_131587.2.
DR   RefSeq; XP_005167910.1; XM_005167853.3.
DR   STRING; 7955.ENSDARP00000091474; -.
DR   Ensembl; ENSDART00000100700; ENSDARP00000091473; ENSDARG00000069289.
DR   Ensembl; ENSDART00000100701; ENSDARP00000091474; ENSDARG00000069289.
DR   Ensembl; ENSDART00000182404; ENSDARP00000150776; ENSDARG00000069289.
DR   Ensembl; ENSDART00000193640; ENSDARP00000154460; ENSDARG00000069289.
DR   GeneID; 58110; -.
DR   KEGG; dre:58110; -.
DR   CTD; 2551; -.
DR   ZFIN; ZDB-GENE-011010-2; gabpa.
DR   eggNOG; KOG3806; Eukaryota.
DR   eggNOG; ENOG410Z0ZF; LUCA.
DR   GeneTree; ENSGT00940000155799; -.
DR   HOGENOM; HOG000285952; -.
DR   KO; K09441; -.
DR   OMA; DLFWTHL; -.
DR   OrthoDB; 526256at2759; -.
DR   TreeFam; TF350537; -.
DR   Proteomes; UP000000437; Chromosome 9.
DR   Bgee; ENSDARG00000069289; Expressed in 31 organ(s), highest expression level in gastrula.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR024668; GABP_asu_N.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR016312; TF_GA-bd_asu.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF11620; GABP-alpha; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PIRSF; PIRSF001703; GABP_alpha; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   1: Evidence at protein level;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   DNA-binding {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594397};
KW   Nucleus {ECO:0000256|RuleBase:RU004019,
KW   ECO:0000256|SAAS:SAAS00594400};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:Q9I9E8};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT   DOMAIN      162    245       PNT. {ECO:0000259|PROSITE:PS51433}.
FT   DOMAIN      310    390       ETS. {ECO:0000259|PROSITE:PS50061}.
FT   REGION      284    306       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   455 AA;  51045 MW;  DC23A5927F566E7F CRC64;
     MSKSETEEMI EIEIDGREKQ ECLEEGIEEQ TITAAELITQ DIDINEPIGN LKKLLEPRLQ
     IPLDGYDICL QDIQLHPDHS LFDQGVKTDG TVQLSVQIVT KPGEEKLNIL EIVKPVETVE
     VVIDPDAAAG EEAHLVEDGQ VIAVERAALP DETSEQVTRW AAALEGYRKE QVRLNIPYDP
     VQWTADQVIH WAVWVMKEFG IDEMEVGGIH IPGRQLCGFS QEEFLQRVPS GEILWSHLEL
     LRKYVLASQD QSQEATVTID QPVQIIPAPV QQATPTAIKV MKHNKTPRAP RISGEERSSP
     GNRTGNNGQI QLWQFLLELL TDKDSRDCIS WVGEEGEFKL NQPELVAQKW GQRKNKPTMN
     YEKLSRALRY YYDGDMISKV QGKRFVYKFV CDLRTLIGYS AAELNNLVTE CEQKKLARVQ
     LQGLGQPVNT VTLATATGQP VTTVTLAAAA LDKDS
//
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