ID OBP_VZVO Reviewed; 835 AA.
AC Q9J3N7;
DT 22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 88.
DE RecName: Full=Replication origin-binding protein;
DE Short=OBP;
DE AltName: Full=OriBP;
GN ORFNames=ORF51;
OS Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Varicellovirus;
OC Varicellovirus humanalpha3; Human herpesvirus 3.
OX NCBI_TaxID=341980;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=V-Oka(Biken);
RX PubMed=10720545; DOI=10.1086/315335;
RA Argaw T., Cohen J.I., Klutch M., Lekstrom K., Yoshikawa T., Asano Y.,
RA Krause P.R.;
RT "Nucleotide sequences that distinguish Oka vaccine from parental Oka and
RT other varicella-zoster virus isolates.";
RL J. Infect. Dis. 181:1153-1157(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Isolate Human/Japan/P-Oka/1970, and
RC Oka varicella vaccine Biken (V-Oka-Biken);
RX PubMed=12388706; DOI=10.1128/jvi.76.22.11447-11459.2002;
RA Gomi Y., Sunamachi H., Mori Y., Nagaike K., Takahashi M., Yamanishi K.;
RT "Comparison of the complete DNA sequences of the Oka varicella vaccine and
RT its parental virus.";
RL J. Virol. 76:11447-11459(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Oka varicella vaccine VarilRix (V-Oka-GSK), and
RC Oka varicella vaccine Varivax (V-Oka-Merck);
RX PubMed=18787000; DOI=10.1128/jvi.00777-08;
RA Tillieux S.L., Halsey W.S., Thomas E.S., Voycik J.J., Sathe G.M.,
RA Vassilev V.;
RT "Complete DNA sequences of two oka strain varicella-zoster virus genomes.";
RL J. Virol. 82:11023-11044(2008).
CC -!- FUNCTION: Functions as a docking protein to recruit essential
CC components of the viral replication machinery to viral DNA origins. In
CC the presence of the major DNA-binding protein, opens dsDNA leading to a
CC conformational change in the origin that facilitates DNA unwinding and
CC subsequent replication (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. Interacts with the major DNA-binding protein.
CC Interacts with the helicase/primase component 52 and the polymerase
CC accessory protein (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the herpesviridae OriBP family. {ECO:0000305}.
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DR EMBL; AF206304; AAF61652.1; -; Genomic_DNA.
DR EMBL; AB097932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB097933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DQ008354; AAY57660.1; -; Genomic_DNA.
DR EMBL; DQ008355; AAY57731.1; -; Genomic_DNA.
DR IntAct; Q9J3N7; 2.
DR MINT; Q9J3N7; -.
DR Proteomes; UP000002603; Genome.
DR Proteomes; UP000008504; Genome.
DR Proteomes; UP000008505; Genome.
DR Proteomes; UP000008506; Genome.
DR GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003450; Replication_origin-bd.
DR Pfam; PF02399; Herpes_ori_bp; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA replication; DNA-binding; Host nucleus;
KW Nucleotide-binding.
FT CHAIN 1..835
FT /note="Replication origin-binding protein"
FT /id="PRO_0000385141"
FT DOMAIN 54..215
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT BINDING 67..74
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 835 AA; 94384 MW; B0386877ACEA9FFB CRC64;
MSPNTGESNA AVYASSTQLA RALYGGDLVS WIKHTHPGIS LELQLDVPVK LIKPGMSQTR
PVTVVRAPMG SGKTTALLEW LQHALKADIS VLVVSCRRSF TQTLIQRFND AGLSGFVTYL
TSETYIMGFK RLIVQLESLH RVSSEAIDSY DVLILDEVMS VIGQLYSPTM RRLSAVDSLL
YRLLNRCSQI IAMDATVNSQ FIDLISGLRG DENIHTIVCT YAGVGFSGRT CTILRDMGID
TLVRVIKRSP EHEDVRTIHQ LRGTFFDELA LRLQCGHNIC IFSSTLSFSE LVAQFCAIFT
DSILILNSTR PLCNVNEWKH FRVLVYTTVV TVGLSFDMAH FHSMFAYIKP MSYGPDMVSV
YQSLGRVRLL LLNEVLMYVD GSRTRCGPLF SPMLLNFTIA NKFQWFPTHT QITNKLCCAF
RQRCANAFTR SNTHLFSRFK YKHLFERCSL WSLADSINIL QTLLASNQIL VVLDGMGPIT
DVSPVQFCAF IHDLRHSANA VASCMRSLRQ DNDSCLTDFG PSGFMADNIT AFMEKYLMES
INTEEQIKVF KALACPIEQP RLVNTAILGA CIRIPEALEA FDVFQKIYTH YASGWFPVLD
KTGEFSIATI TTAPNLTTHW ELFRRCAYIA KTLKWNPSTE GCVTQVLDTD INTLFNQHGD
SLAQLIFEVM RCNVTDAKII LNRPVWRTTG FLDGCHNQCF RPIPTKHEYN IALFRLIWEQ
LFGARVTKST QTFPGSTRVK NLKKKDLETL LDSINVDRSA CRTYRQLYNL LMSHRHSFSQ
QRYKITAPAW ARHVYFQAHQ MHLAPHAEAM LQLALSELSP GSWPRINGAV NFESL
//
