GenomeNet

Database: UniProt
Entry: Q9JI18
LinkDB: Q9JI18
Original site: Q9JI18 
ID   LRP1B_MOUSE             Reviewed;        4599 AA.
AC   Q9JI18; Q8BZD3; Q8BZM7;
DT   26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   07-NOV-2018, entry version 139.
DE   RecName: Full=Low-density lipoprotein receptor-related protein 1B;
DE            Short=LRP-1B;
DE   AltName: Full=Low-density lipoprotein receptor-related protein-deleted in tumor;
DE            Short=LRP-DIT;
DE   Flags: Precursor;
GN   Name=Lrp1b; Synonyms=Lrpdit;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Yaklichkin S., Lisitsyn N.;
RT   "The structure of the mouse homologue of the human candidate tumor
RT   suppressor gene LRP1B/LRP-DIT.";
RL   Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3770-4599.
RC   STRAIN=C57BL/6J; TISSUE=Cerebellum;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and
RT   expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Potential cell surface proteins that bind and
CC       internalize ligands in the process of receptor-mediated
CC       endocytosis.
CC   -!- SUBUNIT: Binds LRPAP1, PLAU, PLAT and SERPINE1; binding is
CC       followed by internalization and degradation of the ligands.
CC       {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q9WVI9-1:Mapk8ip1; NbExp=3; IntAct=EBI-8294317, EBI-288461;
CC       Q80VC8:Pick1; NbExp=4; IntAct=EBI-8294317, EBI-8521477;
CC       P69566:Ranbp9; NbExp=2; IntAct=EBI-8294317, EBI-772305;
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the LDLR family. {ECO:0000305}.
DR   EMBL; AF270884; AAF81758.1; -; mRNA.
DR   EMBL; AK035795; BAC29188.1; -; mRNA.
DR   EMBL; AK034122; BAC28594.1; -; mRNA.
DR   CCDS; CCDS84520.1; -.
DR   UniGene; Mm.441398; -.
DR   ProteinModelPortal; Q9JI18; -.
DR   IntAct; Q9JI18; 7.
DR   MINT; Q9JI18; -.
DR   STRING; 10090.ENSMUSP00000054275; -.
DR   iPTMnet; Q9JI18; -.
DR   PhosphoSitePlus; Q9JI18; -.
DR   PaxDb; Q9JI18; -.
DR   PRIDE; Q9JI18; -.
DR   MGI; MGI:2151136; Lrp1b.
DR   eggNOG; KOG1215; Eukaryota.
DR   eggNOG; ENOG410XP34; LUCA.
DR   HOVERGEN; HBG006292; -.
DR   InParanoid; Q9JI18; -.
DR   ChiTaRS; Lrp1b; mouse.
DR   PRO; PR:Q9JI18; -.
DR   Proteomes; UP000000589; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IDA:MGI.
DR   GO; GO:0043235; C:receptor complex; ISO:MGI.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005041; F:low-density lipoprotein particle receptor activity; IDA:MGI.
DR   GO; GO:0050750; F:low-density lipoprotein particle receptor binding; IDA:MGI.
DR   GO; GO:0001701; P:in utero embryonic development; IMP:MGI.
DR   CDD; cd00112; LDLa; 30.
DR   Gene3D; 2.120.10.30; -; 8.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR026823; cEGF.
DR   InterPro; IPR032485; DUF5050.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   Pfam; PF12662; cEGF; 1.
DR   Pfam; PF16472; DUF5050; 1.
DR   Pfam; PF00008; EGF; 1.
DR   Pfam; PF07645; EGF_CA; 2.
DR   Pfam; PF00057; Ldl_recept_a; 31.
DR   Pfam; PF00058; Ldl_recept_b; 10.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00181; EGF; 24.
DR   SMART; SM00179; EGF_CA; 6.
DR   SMART; SM00192; LDLa; 32.
DR   SMART; SM00135; LY; 36.
DR   SUPFAM; SSF57184; SSF57184; 3.
DR   SUPFAM; SSF57424; SSF57424; 32.
DR   PROSITE; PS00010; ASX_HYDROXYL; 4.
DR   PROSITE; PS00022; EGF_1; 5.
DR   PROSITE; PS01186; EGF_2; 9.
DR   PROSITE; PS50026; EGF_3; 9.
DR   PROSITE; PS01187; EGF_CA; 3.
DR   PROSITE; PS01209; LDLRA_1; 27.
DR   PROSITE; PS50068; LDLRA_2; 32.
DR   PROSITE; PS51120; LDLRB; 36.
PE   1: Evidence at protein level;
KW   Calcium; Complete proteome; Disulfide bond; EGF-like domain;
KW   Endocytosis; Glycoprotein; Membrane; Receptor; Reference proteome;
KW   Repeat; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL        1     20       {ECO:0000255}.
FT   CHAIN        21   4599       Low-density lipoprotein receptor-related
FT                                protein 1B.
FT                                /FTId=PRO_0000017320.
FT   TOPO_DOM     21   4444       Extracellular. {ECO:0000255}.
FT   TRANSMEM   4445   4467       Helical. {ECO:0000255}.
FT   TOPO_DOM   4468   4599       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       31     70       LDL-receptor class A 1.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN       76    114       LDL-receptor class A 2.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN      116    154       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      155    194       EGF-like 2; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   REPEAT      295    337       LDL-receptor class B 1.
FT   REPEAT      338    381       LDL-receptor class B 2.
FT   REPEAT      382    425       LDL-receptor class B 3.
FT   DOMAIN      471    517       EGF-like 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT      568    610       LDL-receptor class B 4.
FT   REPEAT      611    656       LDL-receptor class B 5.
FT   REPEAT      657    706       LDL-receptor class B 6.
FT   REPEAT      707    750       LDL-receptor class B 7.
FT   DOMAIN      794    834       EGF-like 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      844    882       LDL-receptor class A 3.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN      885    923       LDL-receptor class A 4.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN      926    963       LDL-receptor class A 5.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN      966   1003       LDL-receptor class A 6.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1005   1043       LDL-receptor class A 7.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1052   1089       LDL-receptor class A 8.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1094   1132       LDL-receptor class A 9.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1135   1174       LDL-receptor class A 10.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1174   1213       EGF-like 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     1214   1253       EGF-like 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT     1300   1346       LDL-receptor class B 8.
FT   REPEAT     1347   1389       LDL-receptor class B 9.
FT   REPEAT     1390   1436       LDL-receptor class B 10.
FT   REPEAT     1437   1480       LDL-receptor class B 11.
FT   REPEAT     1481   1522       LDL-receptor class B 12.
FT   DOMAIN     1527   1570       EGF-like 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT     1618   1660       LDL-receptor class B 13.
FT   REPEAT     1661   1704       LDL-receptor class B 14.
FT   REPEAT     1705   1744       LDL-receptor class B 15.
FT   REPEAT     1745   1787       LDL-receptor class B 16.
FT   DOMAIN     1834   1875       EGF-like 8. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT     1922   1964       LDL-receptor class B 17.
FT   REPEAT     1965   2007       LDL-receptor class B 28.
FT   REPEAT     2008   2051       LDL-receptor class B 19.
FT   REPEAT     2052   2095       LDL-receptor class B 20.
FT   DOMAIN     2143   2183       EGF-like 9. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT     2239   2280       LDL-receptor class B 21.
FT   REPEAT     2281   2329       LDL-receptor class B 22.
FT   REPEAT     2330   2374       LDL-receptor class B 23.
FT   REPEAT     2375   2416       LDL-receptor class B 24.
FT   REPEAT     2417   2459       LDL-receptor class B 25.
FT   DOMAIN     2464   2504       EGF-like 10. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     2509   2548       LDL-receptor class A 11.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2551   2587       LDL-receptor class A 12.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2590   2626       LDL-receptor class A 13.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2629   2675       LDL-receptor class A 14.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2681   2717       LDL-receptor class A 15.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2719   2757       LDL-receptor class A 16.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2760   2800       LDL-receptor class A 17.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2804   2841       LDL-receptor class A 18.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2844   2885       LDL-receptor class A 19.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2890   2926       LDL-receptor class A 20.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2927   2967       EGF-like 11. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     2968   3008       EGF-like 12; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   REPEAT     3055   3098       LDL-receptor class B 26.
FT   REPEAT     3099   3141       LDL-receptor class B 27.
FT   REPEAT     3142   3185       LDL-receptor class B 28.
FT   REPEAT     3186   3224       LDL-receptor class B 29.
FT   REPEAT     3225   3268       LDL-receptor class B 30.
FT   DOMAIN     3273   3314       EGF-like 13. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     3316   3353       LDL-receptor class A 21.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3356   3392       LDL-receptor class A 22.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3395   3432       LDL-receptor class A 23.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3435   3472       LDL-receptor class A 24.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3475   3511       LDL-receptor class A 25.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3514   3550       LDL-receptor class A 26.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3552   3588       LDL-receptor class A 27.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3593   3629       LDL-receptor class A 28.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3631   3668       LDL-receptor class A 29.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3673   3711       LDL-receptor class A 30.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3714   3752       LDL-receptor class A 31.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3761   3797       LDL-receptor class A 32.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3801   3843       EGF-like 14. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     3844   3881       EGF-like 15. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT     3933   3980       LDL-receptor class B 31.
FT   REPEAT     3981   4038       LDL-receptor class B 32.
FT   REPEAT     4039   4082       LDL-receptor class B 33.
FT   REPEAT     4083   4127       LDL-receptor class B 34.
FT   DOMAIN     4171   4208       EGF-like 16. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     4213   4249       EGF-like 17. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     4249   4285       EGF-like 18. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     4285   4321       EGF-like 19. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     4321   4357       EGF-like 20. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     4357   4392       EGF-like 21. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     4390   4427       EGF-like 22. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   MOTIF      4492   4495       Endocytosis signal. {ECO:0000255}.
FT   MOTIF      4559   4562       Endocytosis signal. {ECO:0000255}.
FT   CARBOHYD    134    134       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    190    190       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    220    220       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    313    313       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    360    360       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    443    443       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    725    725       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    758    758       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    829    829       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    883    883       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    919    919       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1041   1041       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1089   1089       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1145   1145       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1209   1209       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1298   1298       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1502   1502       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1549   1549       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1636   1636       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1754   1754       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1816   1816       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1921   1921       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1983   1983       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2105   2105       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2458   2458       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2488   2488       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2507   2507       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2549   2549       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2626   2626       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2647   2647       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2802   2802       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2892   2892       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3034   3034       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3066   3066       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3076   3076       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3164   3164       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3310   3310       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3316   3316       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3682   3682       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3877   3877       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3894   3894       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3906   3906       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4017   4017       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4204   4204       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4381   4381       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4420   4420       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     32     45       {ECO:0000250}.
FT   DISULFID     39     58       {ECO:0000250}.
FT   DISULFID     52     69       {ECO:0000250}.
FT   DISULFID     77     90       {ECO:0000250}.
FT   DISULFID     84    103       {ECO:0000250}.
FT   DISULFID     97    113       {ECO:0000250}.
FT   DISULFID    159    169       {ECO:0000250}.
FT   DISULFID    165    178       {ECO:0000250}.
FT   DISULFID    180    193       {ECO:0000250}.
FT   DISULFID    798    809       {ECO:0000250}.
FT   DISULFID    805    818       {ECO:0000250}.
FT   DISULFID    820    833       {ECO:0000250}.
FT   DISULFID    845    857       {ECO:0000250}.
FT   DISULFID    852    870       {ECO:0000250}.
FT   DISULFID    864    881       {ECO:0000250}.
FT   DISULFID    886    898       {ECO:0000250}.
FT   DISULFID    893    911       {ECO:0000250}.
FT   DISULFID    905    922       {ECO:0000250}.
FT   DISULFID    927    939       {ECO:0000250}.
FT   DISULFID    934    952       {ECO:0000250}.
FT   DISULFID    946    962       {ECO:0000250}.
FT   DISULFID    967    980       {ECO:0000250}.
FT   DISULFID    975    993       {ECO:0000250}.
FT   DISULFID    987   1002       {ECO:0000250}.
FT   DISULFID   1006   1018       {ECO:0000250}.
FT   DISULFID   1013   1031       {ECO:0000250}.
FT   DISULFID   1025   1042       {ECO:0000250}.
FT   DISULFID   1053   1066       {ECO:0000250}.
FT   DISULFID   1060   1079       {ECO:0000250}.
FT   DISULFID   1073   1088       {ECO:0000250}.
FT   DISULFID   1095   1109       {ECO:0000250}.
FT   DISULFID   1103   1122       {ECO:0000250}.
FT   DISULFID   1116   1131       {ECO:0000250}.
FT   DISULFID   1136   1150       {ECO:0000250}.
FT   DISULFID   1143   1163       {ECO:0000250}.
FT   DISULFID   1157   1173       {ECO:0000250}.
FT   DISULFID   1176   1187       {ECO:0000250}.
FT   DISULFID   1183   1197       {ECO:0000250}.
FT   DISULFID   1199   1212       {ECO:0000250}.
FT   DISULFID   1531   1544       {ECO:0000250}.
FT   DISULFID   1540   1554       {ECO:0000250}.
FT   DISULFID   1556   1569       {ECO:0000250}.
FT   DISULFID   1838   1849       {ECO:0000250}.
FT   DISULFID   1845   1859       {ECO:0000250}.
FT   DISULFID   1861   1874       {ECO:0000250}.
FT   DISULFID   2147   2158       {ECO:0000250}.
FT   DISULFID   2154   2168       {ECO:0000250}.
FT   DISULFID   2170   2182       {ECO:0000250}.
FT   DISULFID   2510   2523       {ECO:0000250}.
FT   DISULFID   2518   2536       {ECO:0000250}.
FT   DISULFID   2530   2547       {ECO:0000250}.
FT   DISULFID   2552   2564       {ECO:0000250}.
FT   DISULFID   2559   2577       {ECO:0000250}.
FT   DISULFID   2571   2586       {ECO:0000250}.
FT   DISULFID   2591   2603       {ECO:0000250}.
FT   DISULFID   2598   2616       {ECO:0000250}.
FT   DISULFID   2610   2625       {ECO:0000250}.
FT   DISULFID   2630   2652       {ECO:0000250}.
FT   DISULFID   2646   2665       {ECO:0000250}.
FT   DISULFID   2659   2674       {ECO:0000250}.
FT   DISULFID   2682   2694       {ECO:0000250}.
FT   DISULFID   2689   2707       {ECO:0000250}.
FT   DISULFID   2701   2716       {ECO:0000250}.
FT   DISULFID   2720   2732       {ECO:0000250}.
FT   DISULFID   2727   2745       {ECO:0000250}.
FT   DISULFID   2739   2756       {ECO:0000250}.
FT   DISULFID   2761   2774       {ECO:0000250}.
FT   DISULFID   2768   2787       {ECO:0000250}.
FT   DISULFID   2781   2799       {ECO:0000250}.
FT   DISULFID   2805   2817       {ECO:0000250}.
FT   DISULFID   2812   2830       {ECO:0000250}.
FT   DISULFID   2824   2840       {ECO:0000250}.
FT   DISULFID   2845   2857       {ECO:0000250}.
FT   DISULFID   2852   2871       {ECO:0000250}.
FT   DISULFID   2865   2884       {ECO:0000250}.
FT   DISULFID   2891   2903       {ECO:0000250}.
FT   DISULFID   2898   2916       {ECO:0000250}.
FT   DISULFID   2910   2925       {ECO:0000250}.
FT   DISULFID   2930   2942       {ECO:0000250}.
FT   DISULFID   2938   2951       {ECO:0000250}.
FT   DISULFID   2953   2966       {ECO:0000250}.
FT   DISULFID   2972   2982       {ECO:0000250}.
FT   DISULFID   2978   2991       {ECO:0000250}.
FT   DISULFID   2993   3007       {ECO:0000250}.
FT   DISULFID   3317   3329       {ECO:0000250}.
FT   DISULFID   3324   3342       {ECO:0000250}.
FT   DISULFID   3336   3352       {ECO:0000250}.
FT   DISULFID   3357   3369       {ECO:0000250}.
FT   DISULFID   3364   3382       {ECO:0000250}.
FT   DISULFID   3376   3391       {ECO:0000250}.
FT   DISULFID   3396   3409       {ECO:0000250}.
FT   DISULFID   3403   3422       {ECO:0000250}.
FT   DISULFID   3416   3431       {ECO:0000250}.
FT   DISULFID   3436   3449       {ECO:0000250}.
FT   DISULFID   3443   3462       {ECO:0000250}.
FT   DISULFID   3456   3471       {ECO:0000250}.
FT   DISULFID   3476   3488       {ECO:0000250}.
FT   DISULFID   3483   3501       {ECO:0000250}.
FT   DISULFID   3495   3510       {ECO:0000250}.
FT   DISULFID   3515   3527       {ECO:0000250}.
FT   DISULFID   3522   3540       {ECO:0000250}.
FT   DISULFID   3534   3549       {ECO:0000250}.
FT   DISULFID   3553   3565       {ECO:0000250}.
FT   DISULFID   3560   3578       {ECO:0000250}.
FT   DISULFID   3572   3587       {ECO:0000250}.
FT   DISULFID   3594   3606       {ECO:0000250}.
FT   DISULFID   3601   3619       {ECO:0000250}.
FT   DISULFID   3613   3628       {ECO:0000250}.
FT   DISULFID   3632   3645       {ECO:0000250}.
FT   DISULFID   3639   3658       {ECO:0000250}.
FT   DISULFID   3652   3667       {ECO:0000250}.
FT   DISULFID   3674   3686       {ECO:0000250}.
FT   DISULFID   3681   3699       {ECO:0000250}.
FT   DISULFID   3693   3710       {ECO:0000250}.
FT   DISULFID   3715   3729       {ECO:0000250}.
FT   DISULFID   3723   3742       {ECO:0000250}.
FT   DISULFID   3736   3751       {ECO:0000250}.
FT   DISULFID   3762   3774       {ECO:0000250}.
FT   DISULFID   3769   3787       {ECO:0000250}.
FT   DISULFID   3781   3796       {ECO:0000250}.
FT   DISULFID   3805   3818       {ECO:0000250}.
FT   DISULFID   3812   3827       {ECO:0000250}.
FT   DISULFID   3829   3842       {ECO:0000250}.
FT   DISULFID   3848   3858       {ECO:0000250}.
FT   DISULFID   3854   3867       {ECO:0000250}.
FT   DISULFID   4217   4227       {ECO:0000250}.
FT   DISULFID   4221   4237       {ECO:0000250}.
FT   DISULFID   4239   4248       {ECO:0000250}.
FT   DISULFID   4253   4263       {ECO:0000250}.
FT   DISULFID   4257   4273       {ECO:0000250}.
FT   DISULFID   4275   4284       {ECO:0000250}.
FT   DISULFID   4289   4299       {ECO:0000250}.
FT   DISULFID   4293   4309       {ECO:0000250}.
FT   DISULFID   4311   4320       {ECO:0000250}.
FT   DISULFID   4325   4335       {ECO:0000250}.
FT   DISULFID   4329   4345       {ECO:0000250}.
FT   DISULFID   4347   4356       {ECO:0000250}.
FT   DISULFID   4394   4404       {ECO:0000250}.
FT   DISULFID   4398   4415       {ECO:0000250}.
FT   DISULFID   4417   4426       {ECO:0000250}.
FT   CONFLICT   4521   4553       Missing (in Ref. 2; BAC29188).
FT                                {ECO:0000305}.
FT   CONFLICT   4552   4552       F -> S (in Ref. 2; BAC28594).
FT                                {ECO:0000305}.
SQ   SEQUENCE   4599 AA;  513634 MW;  11462A3354FFB200 CRC64;
     MSQLLLAILT LSGLLPNAEV LIVGANQDQH LCDPGEFLCH DHVTCVSQSW LCDGDPDCPD
     QSDESLDTCP EEVEIKCPLN HIACHGSSAC VHLSKLCNGV VDCPDGFDEG GHCQELLPSC
     QQLNCQFKCA MVRNATRCYC EDGFEVAEDG RSCKDQDECS IYGICSQTCK NTYGSYACSC
     VEGYIMQSDN RSCKVKHEPT DKAPMLLISS LETIELFYIN GSKMTTLSSA NRNEIHTLDF
     IYSEEMICWI ESRESSNQLK CGQITKAGRL TDQRIINSLQ SFQNVEQMAF DWLTRNIYFV
     DHVSDRIFVC NFNGSVCVTL IESELHNPKA IAADPIAGKL FFTDYGNVPK IERCDLDGMN
     RTRIVYSKAE QPSALALDLV NRLVYWVDLY LDYVGVVDYQ GKNRHTIVQG RQVKHLYGIT
     VFEDYLYATS SDNFNIIRIN RFNGTDIHSI IKMESARGIR TYQKRTQPTV RSHACEVDAY
     GMPGGCSHIC LLSSSYKTRT CRCRTGFNMG SDGRSCKRPK NELFLFYGKG RPGIVRGMDL
     NTKIADECMI PIENLVNPRA LDFHAEANYI YFADTTSFLI GRQKIDGTER ETILKDDLDN
     VEGIAVDWIG NNLYWTNDGH RKTINVARLE KASQSRKTLL EGGMSHPRAI VVDPVNGWMY
     WTDWKEDKID DSVGRIEKAW MDGVNRQVFV TSKMLWPNGL TLDFHTSTLY WCDAYYDHIE
     KVFLNGTHRK VVYSGKELNH PFGLSHHGNY VFWTDYMNGS IFQLDLMTNE VTLLRHERAP
     LFGLQIYDPR KQQGDNMCRI NNGGCGTLCL AIPAGRVCAC ADNQLLDENG TTCTFNPEEI
     RFHICKPGEF RCKNKHCIQA RWKCDGDDDC LDGSDEDSVT CFNHSCPDDQ FKCQNNRCIP
     KRWLCDGAND CGSNEDESNQ TCTARTCQAD QFSCGNGRCI PTAWLCDRED DCGDQTDEVA
     SCEFPTCEPL TQFICKSGRC ISNKWHCDTD DDCGDRSDEV GCVHSCLDDQ FRCSSGRCIP
     GHWACDGDND CGDFSDETHI NCTKEEARSP AGCIGNEFQC RPDGNCIPDL WRCDGEKDCE
     DGSDEKGCNG TIRLCDHKTK FSCRSTGRCI NNAWVCDGDV DCEDQSDEED CDSFLCGPPK
     YPCANDTSVC LQPEKLCNGR KDCPDGSDEG DLCDECSLNN GGCSNHCSVV PGRGIVCSCP
     EGHQLKKDNR TCEIVDYCAS HLRCSQVCEQ QKHMVKCSCY EGWALGTDGE SCTSVDSFEA
     FIIFSIRHEI RRIDLHKGDY SLLVPGLRNT IALDFHFNQS LLYWTDVVED RIYRGKLSES
     GGVSAIEVVV EHGLATPEGL TVDWIAGNIY WIDSNLDQIE VSKLDGSLRA TLIAGAMEHP
     RAIALDPRYG ILFWTDWDAN FPRIESASMS GAGRKTIYKD MKTGAWPNGL TVDHFERRIV
     WTDARSDAIY SAFYDGTNMI EIIRGHEYLS HPFAVSLYGS EVYWTDWRTN TLAKANKWTG
     QNVSVIQKTS AQPFDLQIYH PSRQPQAPNP CAANEGRGPC SHLCLINHNR SAACACPHLM
     KLSSDKKTCY EMKKFLLYAR RSEIRGVDID NPYVNFITAF TVPDIDDVAV IDFDASEERL
     YWTDIKTQTI TRAFINGTGL ETVISRDIQS IRGLAVDWVS RNLYWISSEF DETQINVARL
     DGSLKTSIIH GIDKPQCLAA HPVRGKLYWT DGNTINMANM DGSNSKILFQ NQKEPVGLSI
     DYVENKLYWI SSGNGTINRC NLDGGNLEVI ESMKEELTKA TALTIMDKKL WWADQNLAQL
     GTCNKRDGRN PSILRNKTSG VVHMKVYDKE AQQGSNSCQV NNGGCSQLCL PTSETTRTCM
     CTVGYYLQKN RMSCQGIESF LMYSVHEGIR GIPLEPRDKV DALMPISGAA FAVGIDFHAE
     NDTIYWTDMG LNKISRAKRD QTWKEDVVTN GLGRVEGIAV DWIAGNIYWT DHGFNLIEVA
     RLNGSFRYVI ISQGLDQPRS IAVHPEKGFL FWTEWGQVPC IGKARLDGSE KVMIVSVGIT
     WPNGISIDYE ENKLYWCDAR SDKIERIDLD TGANREVLLS GSNVDLFSVA VFGAYIYWSD
     RAHANGSVRR GHKNDATETV TMRTGLGVNL KEIKIFNRVR EKGTNVCAKE NGGCQQLCLY
     RGNSRRTCAC AHGYLAGDGV TCLRHEGYLL YSGRTILKSI HLSDETNLNS PVRPYENPNY
     FKNIIALAFD YNQRREGTNR IFYSDAHFGN IQLIKDNWED RQVIVENVGS VEGLAYHRAW
     DTLYWTSSST SSITRHTVDQ TRPGAIDREA VITMSEDDHP HVLALDECQN LMFWTNWNEQ
     HPSIMRATLT GKNAHVVVST DILTPNGLTI DHRAEKLYFS DGSLGKIERC EYDGSQRHVI
     VKSGPGTFLS LAVYDSYIFW SDWGRRAILR SNKYTGGETK ILRSDIPHQP MGIIAVANDT
     NSCELSPCAL LNGGCHDLCL LTPDGRVNCS CRGDRVLLAN NRCVTKNSSC NIYSEFECGN
     GDCVDYVLTC DGIPHCKDKS DEKLLYCENR SCRSGFKPCY NRRCVPHGKL CDGTNDCGDS
     SDELDCKVST CSTVEFRCAD GTCIPRSARC NQNMDCSDAS DEKGCNNTDC THFYKLGVKS
     TGFIRCNSTS LCVLPSWICD GSNDCGDYSD ELKCPVQNKH KCEENYFGCP SGRCILNTWV
     CDGQKDCEDG LDELHCDSSC SWNQFACSVK KCISKHWICD GEDDCGDSLD ESDSICGAVT
     CAADMFSCQG SHACVPQHWL CDGERDCPDG SDELSSAGCA PNNTCDENAF MCHNKVCIPK
     QFVCDHDDDC GDGSDEFLQC GYRQCGPEEF RCADGRCLVN TLWQCDGDFD CPDSSDEAPI
     NPRCRSAEHS CNSSFFMCKN GRCIPSDGLC DIRDDCGDGS DETNCHINEC LSKKISGCSQ
     DCQDLPVSYK CKCWPGFQLK DDGKTCVDID ECSSGFPCSQ QCINTYGTYK CHCAEGYETQ
     PDNPNGCRSL SDEEPFLILA DQHEIRKIST DGSNYTLLKQ GLNNVIALDF DYREEFIYWI
     DSSRPNGSRI NRMCLNGSDI KVVHNTAVPN ALAVDWIGKN LYWSDTEKRI IEVSKLNGLY
     PTVLVSKRLK FPRDLSLDPR AGNLYWIDCC EYPHIGRVGM DGTNQSVVIE TKISRPMALT
     IDYVNHRLYW ADENHIEFSN MDGSHRHKVP NQDIPGVIAL TLFEDYIYWT DGKTKSLSRV
     HKTSGADRLS LINSWHAITD IQVYHSYRQP DVSKHLCTVN NGGCSHLCLL GPGKTHTCAC
     PTNFYLAADN RTCLSNCTAS QFRCKTDKCI PFWWKCDTVD DCGDGSDEPD DCPEFKCQPG
     RFQCGTGLCA LPAFICDGEN DCGDNSDELN CDTHVCLAGQ FKCTKNKKCI PVNLRCNGQD
     DCGDEEDEKD CPENSCSPDY FQCKTTKHCI SKLWVCDEDP DCADASDEAN CDKKTCGPHE
     FQCKNNNCIP DHWRCDNQND CSDNSDEDNC KPQTCTLKDF LCSNGDCVSS RFWCDGEFDC
     ADGSDEKNCE TSCSKDQFQC SNGQCLSAKW KCDGHEDCKY GEDEKNCEPA FPVCSSSEYM
     CASGGCLSAS LKCNGEPDCV DGSDEMDCVI ECKEDQFQCK NKAYCIPIRW LCDGIYDCVD
     GSDEETCGRG GSICRDDEFL CNNSLCKLHF WVCDGEDDCG DNSDEAPDMC VKFLCPPTRP
     YRCRNDRICL QLEKICNGIN DCGDNSDEEH CSGKLSLKSK PCKKDEFTCS NRNCIPMELQ
     CDSLDDCGDG SDEQGCLKTP IEHTCENNGN PCGDDAYCNQ IKTSVFCRCK PGFQRNMKGR
     ECADLNECLL FGICSHHCLN TRGSYKCVCD QNFQEKNNSC IAKGSEDQAL YIANDTDILG
     FVYPFNYSGG HQQISHVEHN SRITGMDVHY QRNVIVWSTQ FNPGGIFYKM IDAREKRQAN
     SGLICPEFKR PRDIAVDWVA GNVYWTDHSR MHWFSYYTTH WTSLRYSINV GQLNGPNCTR
     LLTNMAGEPY AIAVNPKRGM MYWTVIGDHS HIEEAAMDGT LRRVLVQKNL QRPTGLTVDH
     FGERIYWADF ELSIIGSVLY DGSSPVVSVS SKQGLLHPHR IDVFEDYIYG AGPKNGIFRV
     QKFGHGSVEV LALGVDKTKS ILVSHRYKQL NLPNPCLDLS CDFLCLLNPS GATCICPEGK
     YMMNGTCHDD SLLDDSCKLT CENGGRCILN EKGDLRCHCW PSYSGGRCEV NHCSNYCQNG
     GTCIPSTLGR PTCICALGFT GPNCGKAVCE DSCHNGGSCV VTAGNQPYCH CQADYTGDRC
     QYYVCHHYCV NSESCTIGND GSVECVCPTR YEGPKCEIDK CVRCHGGHCI INKDNEDIFC
     NCTNGKIASS CQLCDGYCYN GGTCQLDPET SIPVCVCSTN WSGTQCERPA PKSSKSEHIS
     TRSIAIIVPL VLLVTLVTTL VIGLVVCKRK RRTKTIRRQP IINGGINVEI GNPSYNMYEV
     DHDHSDGGLL EPSFMIDPVK SRYIGGGSSA FKLPHTAPPI YLNSDLKGPL TFGPTNYSNP
     VYAKLYMDGQ NCRNSLASVD ERKELLPKKI EIGIRETVA
//
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