ID UVRA_NEIMA Reviewed; 948 AA.
AC Q9JUS4; A1IRH9;
DT 26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 132.
DE RecName: Full=UvrABC system protein A {ECO:0000255|HAMAP-Rule:MF_00205};
DE Short=UvrA protein {ECO:0000255|HAMAP-Rule:MF_00205};
DE AltName: Full=Excinuclease ABC subunit A {ECO:0000255|HAMAP-Rule:MF_00205};
GN Name=uvrA {ECO:0000255|HAMAP-Rule:MF_00205}; OrderedLocusNames=NMA1159;
OS Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 /
OS Z2491).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=122587;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 15465 / Z2491;
RX PubMed=10761919; DOI=10.1038/35006655;
RA Parkhill J., Achtman M., James K.D., Bentley S.D., Churcher C.M.,
RA Klee S.R., Morelli G., Basham D., Brown D., Chillingworth T., Davies R.M.,
RA Davis P., Devlin K., Feltwell T., Hamlin N., Holroyd S., Jagels K.,
RA Leather S., Moule S., Mungall K.L., Quail M.A., Rajandream M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Whitehead S., Spratt B.G.,
RA Barrell B.G.;
RT "Complete DNA sequence of a serogroup A strain of Neisseria meningitidis
RT Z2491.";
RL Nature 404:502-506(2000).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein.
CC A damage recognition complex composed of 2 UvrA and 2 UvrB subunits
CC scans DNA for abnormalities. When the presence of a lesion has been
CC verified by UvrB, the UvrA molecules dissociate. {ECO:0000255|HAMAP-
CC Rule:MF_00205}.
CC -!- SUBUNIT: Forms a heterotetramer with UvrB during the search for
CC lesions. {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00205}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC {ECO:0000255|HAMAP-Rule:MF_00205}.
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DR EMBL; AL157959; CAM08365.1; -; Genomic_DNA.
DR PIR; B81883; B81883.
DR RefSeq; WP_002244995.1; NC_003116.1.
DR AlphaFoldDB; Q9JUS4; -.
DR SMR; Q9JUS4; -.
DR EnsemblBacteria; CAM08365; CAM08365; NMA1159.
DR KEGG; nma:NMA1159; -.
DR HOGENOM; CLU_001370_0_2_4; -.
DR Proteomes; UP000000626; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd03270; ABC_UvrA_I; 1.
DR CDD; cd03271; ABC_UvrA_II; 1.
DR Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 2.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_00205; UvrA; 1.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004602; UvrA.
DR InterPro; IPR041552; UvrA_DNA-bd.
DR InterPro; IPR041102; UvrA_inter.
DR NCBIfam; TIGR00630; uvra; 1.
DR PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR PANTHER; PTHR43152:SF3; UVRABC SYSTEM PROTEIN A; 1.
DR Pfam; PF17755; UvrA_DNA-bind; 1.
DR Pfam; PF17760; UvrA_inter; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; DNA damage; DNA excision; DNA repair; DNA-binding;
KW Excision nuclease; Metal-binding; Nucleotide-binding; Repeat; SOS response;
KW Zinc; Zinc-finger.
FT CHAIN 1..948
FT /note="UvrABC system protein A"
FT /id="PRO_0000093072"
FT DOMAIN 319..596
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT DOMAIN 616..945
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 262..289
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT ZN_FING 748..774
FT /note="C4-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 42..49
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
FT BINDING 649..656
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00205"
SQ SEQUENCE 948 AA; 105192 MW; E98717DF762B9A0D CRC64;
MCNHHPKHSH GNDTIRIRGA RTHNLKNVDL DIPRHKLVVV TGLSGSGKSS LAFDTLYAEG
QRRYVESLSA YARQFLQMMD KPDVDLIEGL SPAISIEQKS TSHNPRSTVG TVTEIHDYLR
LLYARVGTPY CPEHKLPLSS QTVSQMVDAV LKLPEDTRVM ILAPAVRERK GEFVDFFADL
QAQGFARVRV DGEVYQLDEV PKLEKNIKHN IDVVIDRVKV KADIKQRLAE SFETALRHGN
ERALAMEMDS GEEHWFSARF ACPVCSYSLP ELEPRLFSFN NPMGSCPTCD GLGNTNFFDP
EKVVAHPELS LASGAIDGWD KRNQFYFQMI QSLARHYGFD VQAAWETLPA KIKKVVLHGS
GKEVIDFTYL SERGTTFNRS HAFEGIIPNL ERRYRETDSE TVREKLREYQ NHRACPSCGG
ARLRKEARYV YVSGEPLHEV SAWPLTKTHR FFETLDLDGN KKQIAEKILK EITERLGFLI
NVGLDYLNLS RSAETLSGGE AQRIRLASQI GSGLTGVMYV LDEPSIGLHQ RDNDRLLATL
KRLRDLGNSV IVVEHDEDAI READFVVDMG PGAGEHGGNV LIADTPENVA KCENSVTGQY
LSGKKSIAVP SERTPVNPGR MLVLKGARGN NLKNVTLELP LGLITCITGV SGSGKSTLIN
DTLAKITARE LNRAQEEPAP YDDIRGLEHL DKVINVDQSP IGRTPRSNPA TYTGLFTPIR
ELFASVPLSR ERGYNVGRFS FNVKGGRCEA CQGDGVIKVE MHFLPDVYVP CEVCHGKRYN
RETLEIQYKG KNISQVLDMT VEEACEFFDA VPTVSRKLQT LMDVGLGYIR LGQSATTLSG
GEAQRVKLAL ELSKRDTGRT LYILDEPTTG LHFADIALLL EVIGRLKGKG NSIVIIEHNL
DVIKTADWIV DLGPEGGDGG GRIIASGSPE EVAKVKGSYT GKYLKNIL
//
