ID Q9JX98_NEIMB Unreviewed; 322 AA.
AC Q9JX98;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE RecName: Full=Lipopolysaccharide heptosyltransferase 1 {ECO:0000256|ARBA:ARBA00044190};
DE EC=2.4.99.23 {ECO:0000256|ARBA:ARBA00044041};
DE AltName: Full=ADP-heptose:lipopolysaccharide heptosyltransferase I {ECO:0000256|ARBA:ARBA00044330};
GN Name=rfaC {ECO:0000313|EMBL:AAF42464.1};
GN OrderedLocusNames=NMB2156 {ECO:0000313|EMBL:AAF42464.1};
OS Neisseria meningitidis serogroup B (strain MC58).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=122586 {ECO:0000313|EMBL:AAF42464.1, ECO:0000313|Proteomes:UP000000425};
RN [1] {ECO:0000313|EMBL:AAF42464.1, ECO:0000313|Proteomes:UP000000425}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC58 {ECO:0000313|EMBL:AAF42464.1,
RC ECO:0000313|Proteomes:UP000000425};
RX PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA Tettelin H., Saunders N.J., Heidelberg J., Jeffries A.C., Nelson K.E.,
RA Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA Gwinn M.L., DeBoy R., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L.,
RA White O., Fleischmann R.D., Dougherty B.A., Mason T., Ciecko A.,
RA Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA Utterback T.R., Khouri H., Qin H., Vamathevan J., Gill J., Scarlato V.,
RA Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA Moxon E.R., Rappuoli R., Venter J.C.;
RT "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT MC58.";
RL Science 287:1809-1815(2000).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ADP-L-glycero-beta-D-manno-heptose + an alpha-Kdo-(2->4)-
CC alpha-Kdo-(2->6)-lipid A = ADP + an L-alpha-D-Hep-(1->5)-[alpha-Kdo-
CC (2->4)]-alpha-Kdo-(2->6)-lipid A + H(+); Xref=Rhea:RHEA:74067,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:61506, ChEBI:CHEBI:176431,
CC ChEBI:CHEBI:193068, ChEBI:CHEBI:456216; EC=2.4.99.23;
CC Evidence={ECO:0000256|ARBA:ARBA00043802};
CC -!- PATHWAY: Bacterial outer membrane biogenesis; LPS core biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004713}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004515}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004515}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004515}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 9 family.
CC {ECO:0000256|ARBA:ARBA00043995}.
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DR EMBL; AE002098; AAF42464.1; -; Genomic_DNA.
DR PIR; B81001; B81001.
DR RefSeq; NP_275141.1; NC_003112.2.
DR RefSeq; WP_002218264.1; NC_003112.2.
DR AlphaFoldDB; Q9JX98; -.
DR STRING; 122586.NMB2156; -.
DR CAZy; GT9; Glycosyltransferase Family 9.
DR PaxDb; 122586-NMB2156; -.
DR KEGG; nme:NMB2156; -.
DR PATRIC; fig|122586.8.peg.2750; -.
DR HOGENOM; CLU_038371_6_0_4; -.
DR InParanoid; Q9JX98; -.
DR OrthoDB; 9767552at2; -.
DR Proteomes; UP000000425; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0008713; F:ADP-heptose-lipopolysaccharide heptosyltransferase activity; IBA:GO_Central.
DR GO; GO:0009244; P:lipopolysaccharide core region biosynthetic process; IBA:GO_Central.
DR CDD; cd03789; GT9_LPS_heptosyltransferase; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR002201; Glyco_trans_9.
DR InterPro; IPR011908; LipoPS_heptosylTferase-I.
DR NCBIfam; TIGR02193; heptsyl_trn_I; 1.
DR PANTHER; PTHR30160:SF19; LIPOPOLYSACCHARIDE HEPTOSYLTRANSFERASE 1; 1.
DR PANTHER; PTHR30160; TETRAACYLDISACCHARIDE 4'-KINASE-RELATED; 1.
DR Pfam; PF01075; Glyco_transf_9; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
PE 3: Inferred from homology;
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Lipopolysaccharide biosynthesis {ECO:0000256|ARBA:ARBA00022985};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000000425};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
SQ SEQUENCE 322 AA; 36198 MW; FAD48F2D05C6CC71 CRC64;
MKILLVRLSS MGDLIHTLPA IEDLARQCPD VELHWLCEAG FADIARLHPF VKKIHVMKWR
QWRKHLFRAE TWREMGHLKQ TLRQEVFDFV LDSQGLIKSA CFAKMAKSPI CGLDKNSARE
GWAALAYVKT YAVPKGKNAV WRNRELFAQV FGYVMPETQV FGLTVPEAGR LKNLAQPYYA
ALHATSRDSK LWPVENWRSL LQKLNEEQQC NIYLPWGNED EKTRAKQIAD GLPFAIVCDK
INLLQAAYLL KYAVGIVGVD TGLLHLANAL EKPVVGIYTD TDPIKTGVQV SPIAKNLGNI
GQIPTADLVY QALMDCVAAD KG
//
