ID Q9JXL3_NEIMB Unreviewed; 714 AA.
AC Q9JXL3;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 133.
DE SubName: Full=Iron-regulated outer membrane protein FrpB {ECO:0000313|EMBL:AAF42315.1};
GN Name=frpB {ECO:0000313|EMBL:AAF42315.1};
GN OrderedLocusNames=NMB1988 {ECO:0000313|EMBL:AAF42315.1};
OS Neisseria meningitidis serogroup B (strain MC58).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=122586 {ECO:0000313|EMBL:AAF42315.1, ECO:0000313|Proteomes:UP000000425};
RN [1] {ECO:0000313|EMBL:AAF42315.1, ECO:0000313|Proteomes:UP000000425}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC58 {ECO:0000313|EMBL:AAF42315.1,
RC ECO:0000313|Proteomes:UP000000425};
RX PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA Tettelin H., Saunders N.J., Heidelberg J., Jeffries A.C., Nelson K.E.,
RA Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA Gwinn M.L., DeBoy R., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L.,
RA White O., Fleischmann R.D., Dougherty B.A., Mason T., Ciecko A.,
RA Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA Utterback T.R., Khouri H., Qin H., Vamathevan J., Gill J., Scarlato V.,
RA Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA Moxon E.R., Rappuoli R., Venter J.C.;
RT "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT MC58.";
RL Science 287:1809-1815(2000).
CC -!- SUBCELLULAR LOCATION: Cell outer membrane
CC {ECO:0000256|ARBA:ARBA00004571}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004571}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC {ECO:0000256|ARBA:ARBA00009810, ECO:0000256|RuleBase:RU003357}.
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DR EMBL; AE002098; AAF42315.1; -; Genomic_DNA.
DR PIR; C81018; C81018.
DR RefSeq; NP_274980.1; NC_003112.2.
DR RefSeq; WP_010981016.1; NC_003112.2.
DR AlphaFoldDB; Q9JXL3; -.
DR SMR; Q9JXL3; -.
DR STRING; 122586.NMB1988; -.
DR PaxDb; 122586-NMB1988; -.
DR KEGG; nme:NMB1988; -.
DR PATRIC; fig|122586.8.peg.2540; -.
DR HOGENOM; CLU_008287_19_4_4; -.
DR InParanoid; Q9JXL3; -.
DR OrthoDB; 9790771at2; -.
DR Proteomes; UP000000425; Chromosome.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0044718; P:siderophore transmembrane transport; IBA:GO_Central.
DR Gene3D; 2.40.170.20; TonB-dependent receptor, beta-barrel domain; 1.
DR Gene3D; 2.170.130.10; TonB-dependent receptor, plug domain; 1.
DR InterPro; IPR012910; Plug_dom.
DR InterPro; IPR037066; Plug_dom_sf.
DR InterPro; IPR039426; TonB-dep_rcpt-like.
DR InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR InterPro; IPR010917; TonB_rcpt_CS.
DR InterPro; IPR010105; TonB_sidphr_rcpt.
DR NCBIfam; TIGR01783; TonB-siderophor; 1.
DR PANTHER; PTHR30069:SF41; TONB-DEPENDENT HEME RECEPTOR A; 1.
DR PANTHER; PTHR30069; TONB-DEPENDENT OUTER MEMBRANE RECEPTOR; 1.
DR Pfam; PF07715; Plug; 1.
DR Pfam; PF00593; TonB_dep_Rec; 1.
DR SUPFAM; SSF56935; Porins; 1.
DR PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE 3: Inferred from homology;
KW Cell outer membrane {ECO:0000256|ARBA:ARBA00023237};
KW Ion transport {ECO:0000256|ARBA:ARBA00022496};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron transport {ECO:0000256|ARBA:ARBA00022496};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003357};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000000425};
KW Signal {ECO:0000256|SAM:SignalP};
KW TonB box {ECO:0000256|ARBA:ARBA00023077, ECO:0000256|RuleBase:RU003357};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane beta strand {ECO:0000256|ARBA:ARBA00022452};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..714
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004327676"
FT DOMAIN 46..144
FT /note="TonB-dependent receptor plug"
FT /evidence="ECO:0000259|Pfam:PF07715"
FT DOMAIN 282..683
FT /note="TonB-dependent receptor-like beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF00593"
SQ SEQUENCE 714 AA; 79150 MW; F8BABF5BDB14CDFE CRC64;
MNTPLFRLSL LSLTLAAGFA HAAENNAKVV LDTVTVKGDR QGSKIRTNIV TLQQKDESTA
TDMRELLKEE PSIDFGGGNG TSQFLTLRGM GQNSVDIKVD NAYSDSQILY HQGRFIVDPA
LVKVVSVQKG AGSASAGIGA TNGAIITKTV DAQDLLKGLD KNWGVRLNSG FASNEGVSYG
ASVFGKEGNF DGLFSYNRNN EKDYEAGKGF RNNFNGGKTV PYSALDKRSY LAKIGTSFGD
GDHRIVLSHM KDQHRGIRTV REEFTVGGDK ERISMERQAP AYRETTQSNT NLAYTGKNLG
FVEKLDANAY VLEKERYSAD DSGTGYAGNV KGPNHTQITT RGMNFNFDSR LAEQTLLKYG
INYRHQEIKP QAFLNSQFKI EDKEKATDEE KNKNRENEKI AKAYRLTNPT KTDTGAYIEA
IHEIDGFTLT GGLRYDRFKV KTHDGKTVSS NNLNPSFGVI WQPHEHWSFS ASHNYASRSP
RLYDALQTHG KRGIISIADG TKAERARNTE IGFNYNDGTF AANGSYFWQT IKDALANPQN
RHDSVAVREA VNAGYIKNHG YELGASYRTG GLTAKVGVSH SKPRFYDTHK DKLLSANPEF
GAQVGRTWTA SLAYRFQNPN LEIGWRGRYV QKAVGSILVA GQKDRNGKLE NVVRKGFGVN
DVFANWKPLG KDTLNVNLSV NNVFNTFYYP HSQRWTNTLP GVGRDVRLGV NYKF
//
