ID Q9K022_NEIMB Unreviewed; 221 AA.
AC Q9K022;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE SubName: Full=NAD(P)H nitroreductase {ECO:0000313|EMBL:AAF41217.1};
GN OrderedLocusNames=NMB0804 {ECO:0000313|EMBL:AAF41217.1};
OS Neisseria meningitidis serogroup B (strain MC58).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=122586 {ECO:0000313|EMBL:AAF41217.1, ECO:0000313|Proteomes:UP000000425};
RN [1] {ECO:0000313|EMBL:AAF41217.1, ECO:0000313|Proteomes:UP000000425}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC58 {ECO:0000313|EMBL:AAF41217.1,
RC ECO:0000313|Proteomes:UP000000425};
RX PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA Tettelin H., Saunders N.J., Heidelberg J., Jeffries A.C., Nelson K.E.,
RA Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA Gwinn M.L., DeBoy R., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L.,
RA White O., Fleischmann R.D., Dougherty B.A., Mason T., Ciecko A.,
RA Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA Utterback T.R., Khouri H., Qin H., Vamathevan J., Gill J., Scarlato V.,
RA Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA Moxon E.R., Rappuoli R., Venter J.C.;
RT "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT MC58.";
RL Science 287:1809-1815(2000).
CC -!- COFACTOR:
CC Name=FMN; Xref=ChEBI:CHEBI:58210;
CC Evidence={ECO:0000256|ARBA:ARBA00001917};
CC -!- SIMILARITY: Belongs to the nitroreductase family.
CC {ECO:0000256|ARBA:ARBA00007118}.
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DR EMBL; AE002098; AAF41217.1; -; Genomic_DNA.
DR PIR; C81155; C81155.
DR RefSeq; NP_273846.1; NC_003112.2.
DR RefSeq; WP_002225416.1; NC_003112.2.
DR AlphaFoldDB; Q9K022; -.
DR STRING; 122586.NMB0804; -.
DR PaxDb; 122586-NMB0804; -.
DR KEGG; nme:NMB0804; -.
DR PATRIC; fig|122586.8.peg.1016; -.
DR HOGENOM; CLU_070764_4_1_4; -.
DR InParanoid; Q9K022; -.
DR OrthoDB; 9809288at2; -.
DR Proteomes; UP000000425; Chromosome.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0018545; F:NAD(P)H nitroreductase activity; IBA:GO_Central.
DR GO; GO:0046256; P:2,4,6-trinitrotoluene catabolic process; IBA:GO_Central.
DR CDD; cd02149; NfsB-like; 1.
DR Gene3D; 3.40.109.10; NADH Oxidase; 1.
DR InterPro; IPR033878; NfsB-like.
DR InterPro; IPR029479; Nitroreductase.
DR InterPro; IPR000415; Nitroreductase-like.
DR PANTHER; PTHR23026; NADPH NITROREDUCTASE; 1.
DR PANTHER; PTHR23026:SF125; OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE; 1.
DR Pfam; PF00881; Nitroreductase; 1.
DR SUPFAM; SSF55469; FMN-dependent nitroreductase-like; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000000425}.
FT DOMAIN 14..200
FT /note="Nitroreductase"
FT /evidence="ECO:0000259|Pfam:PF00881"
SQ SEQUENCE 221 AA; 24703 MW; A1B9E6C21F0F4C3D CRC64;
MTVLSKEQVL SAFKNRKSCR HYDAARKISA EDFQFILELG RLSPSSVGSE PWQFIVVQNP
EIRQAIKPFS WGMADALDTA SHLVVFLAKK NARSDSPFML ESLKRRGVTE PDAVAKSLAR
YQAFQADDIK ILDDSRALFD WCCRQTYIAL ANMMTGAAMA GIDSCPVEGF NYAEMERILS
GQFGLFDAAE WGVSVAATFG YRVQEIATKA RRPLEETVIW A
//
