ID Q9K0A9_NEIMB Unreviewed; 315 AA.
AC Q9K0A9;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 24-JAN-2024, entry version 105.
DE SubName: Full=Transporter {ECO:0000313|EMBL:AAF41122.1};
GN OrderedLocusNames=NMB0705 {ECO:0000313|EMBL:AAF41122.1};
OS Neisseria meningitidis serogroup B (strain MC58).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=122586 {ECO:0000313|EMBL:AAF41122.1, ECO:0000313|Proteomes:UP000000425};
RN [1] {ECO:0000313|EMBL:AAF41122.1, ECO:0000313|Proteomes:UP000000425}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC58 {ECO:0000313|EMBL:AAF41122.1,
RC ECO:0000313|Proteomes:UP000000425};
RX PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA Tettelin H., Saunders N.J., Heidelberg J., Jeffries A.C., Nelson K.E.,
RA Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA Gwinn M.L., DeBoy R., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L.,
RA White O., Fleischmann R.D., Dougherty B.A., Mason T., Ciecko A.,
RA Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA Utterback T.R., Khouri H., Qin H., Vamathevan J., Gill J., Scarlato V.,
RA Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA Moxon E.R., Rappuoli R., Venter J.C.;
RT "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT MC58.";
RL Science 287:1809-1815(2000).
RN [2] {ECO:0007829|PDB:3ZUX, ECO:0007829|PDB:3ZUY}
RP X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS).
RX PubMed=21976025; DOI=10.1038/nature10450;
RA Hu N.J., Iwata S., Cameron A.D., Drew D.;
RT "Crystal structure of a bacterial homologue of the bile acid sodium
RT symporter ASBT.";
RL Nature 478:408-411(2011).
RN [3] {ECO:0007829|PDB:8OYF, ECO:0007829|PDB:8OYG}
RP X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS).
RX DOI=10.1101/2023.06.02.543391;
RA Becker P., Naughton F.B., Brotherton D.H., Pacheco-Gomez R., Beckstein O.,
RA Cameron A.D.;
RT "Mechanism of substrate binding and transport in BASS transporters.";
RL bioRxiv 0:0-0(2023).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AE002098; AAF41122.1; -; Genomic_DNA.
DR PIR; B81168; B81168.
DR RefSeq; NP_273747.1; NC_003112.2.
DR RefSeq; WP_002244055.1; NC_003112.2.
DR PDB; 3ZUX; X-ray; 2.20 A; A=1-315.
DR PDB; 3ZUY; X-ray; 2.20 A; A=1-315.
DR PDB; 8OYF; X-ray; 2.10 A; A=1-315.
DR PDB; 8OYG; X-ray; 2.30 A; A=1-315.
DR PDBsum; 3ZUX; -.
DR PDBsum; 3ZUY; -.
DR AlphaFoldDB; Q9K0A9; -.
DR SMR; Q9K0A9; -.
DR STRING; 122586.NMB0705; -.
DR TCDB; 2.A.28.2.4; the bile acid:na(+) symporter (bass) family.
DR PaxDb; 122586-NMB0705; -.
DR KEGG; nme:NMB0705; -.
DR PATRIC; fig|122586.8.peg.898; -.
DR HOGENOM; CLU_034788_1_1_4; -.
DR InParanoid; Q9K0A9; -.
DR OMA; QFTIMPL; -.
DR OrthoDB; 9806785at2; -.
DR EvolutionaryTrace; Q9K0A9; -.
DR Proteomes; UP000000425; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.1530.20; -; 1.
DR InterPro; IPR002657; BilAc:Na_symport/Acr3.
DR InterPro; IPR004710; Bilac:Na_transpt.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR PANTHER; PTHR10361:SF28; RH04535P; 1.
DR PANTHER; PTHR10361; SODIUM-BILE ACID COTRANSPORTER; 1.
DR Pfam; PF01758; SBF; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3ZUX, ECO:0007829|PDB:3ZUY};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000425};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 38..57
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 69..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..151
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..244
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 265..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 315 AA; 32937 MW; 6AB4546AB1CDF486 CRC64;
MNILSKISSF IGKTFSLWAA LFAAAAFFAP DTFKWAGPYI PWLLGIIMFG MGLTLKPSDF
DILFKHPKVV IIGVIAQFAI MPATAWLLSK LLNLPAEIAV GVILVGCCPG GTASNVMTYL
ARGNVALSVA VTSVSTLISP LLTPAIFLML AGEMLEIQAA GMLMSIVKMV LLPIVLGLIV
HKVLGSKTEK LTDALPLVSV AAIVLIIGAV VGASKGKIME SGLLIFAVVV LHNGIGYLLG
FFAAKWTGLP YDAQKTLTIE VGMQNSGLAA ALAAAHFAAA PVVAVPGALF SVWHNISGSL
LATYWAAKAG KHKKP
//