ID Q9K1E6_NEIMB Unreviewed; 658 AA.
AC Q9K1E6;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 138.
DE SubName: Full=Glutathione-regulated potassium-efflux system protein {ECO:0000313|EMBL:AAF40666.1};
GN Name=kefB {ECO:0000313|EMBL:AAF40666.1};
GN OrderedLocusNames=NMB0209 {ECO:0000313|EMBL:AAF40666.1};
OS Neisseria meningitidis serogroup B (strain MC58).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Neisseriales; Neisseriaceae;
OC Neisseria.
OX NCBI_TaxID=122586 {ECO:0000313|EMBL:AAF40666.1, ECO:0000313|Proteomes:UP000000425};
RN [1] {ECO:0000313|EMBL:AAF40666.1, ECO:0000313|Proteomes:UP000000425}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MC58 {ECO:0000313|EMBL:AAF40666.1,
RC ECO:0000313|Proteomes:UP000000425};
RX PubMed=10710307; DOI=10.1126/science.287.5459.1809;
RA Tettelin H., Saunders N.J., Heidelberg J., Jeffries A.C., Nelson K.E.,
RA Eisen J.A., Ketchum K.A., Hood D.W., Peden J.F., Dodson R.J., Nelson W.C.,
RA Gwinn M.L., DeBoy R., Peterson J.D., Hickey E.K., Haft D.H., Salzberg S.L.,
RA White O., Fleischmann R.D., Dougherty B.A., Mason T., Ciecko A.,
RA Parksey D.S., Blair E., Cittone H., Clark E.B., Cotton M.D.,
RA Utterback T.R., Khouri H., Qin H., Vamathevan J., Gill J., Scarlato V.,
RA Masignani V., Pizza M., Grandi G., Sun L., Smith H.O., Fraser C.M.,
RA Moxon E.R., Rappuoli R., Venter J.C.;
RT "Complete genome sequence of Neisseria meningitidis serogroup B strain
RT MC58.";
RL Science 287:1809-1815(2000).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AE002098; AAF40666.1; -; Genomic_DNA.
DR PIR; B81225; B81225.
DR RefSeq; NP_273267.1; NC_003112.2.
DR RefSeq; WP_002243958.1; NC_003112.2.
DR AlphaFoldDB; Q9K1E6; -.
DR STRING; 122586.NMB0209; -.
DR PaxDb; 122586-NMB0209; -.
DR DNASU; 902317; -.
DR KEGG; nme:NMB0209; -.
DR PATRIC; fig|122586.8.peg.258; -.
DR HOGENOM; CLU_005126_9_0_4; -.
DR InParanoid; Q9K1E6; -.
DR OrthoDB; 9781411at2; -.
DR Proteomes; UP000000425; Chromosome.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:UniProtKB-KW.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR46157; K(+) EFFLUX ANTIPORTER 3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR46157:SF4; K(+) EFFLUX ANTIPORTER 3, CHLOROPLASTIC; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR PROSITE; PS51202; RCK_C; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 4: Predicted;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000000425};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 31..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 55..74
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 86..108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 114..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..170
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..234
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 328..347
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 359..382
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 410..532
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
FT DOMAIN 572..656
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 658 AA; 71197 MW; B216DBD029219BCB CRC64;
MNEFSLAPIV IVLLVSVITV ILCRKFNIPS MLGYLLVGFL AGPGMLSLIP KSHATDYLGE
IGIVFLMFSI GLEFSLPKLR AMRRLVFGLG GLQVGITMLS VMGILMLTGV PFNWAFAVSG
ALAMSSTAIV SRILSEKTEL GQPHGQMAMG VLLMQDIAVV PLMILIPALA GGGDGNIWAA
LGLAFAKMLL TLGLLFFVGS KIMSRWFRMV AKRKSSELFM INVLLVTLGV AYLTELEGLS
MALGAFVAGM LLSETEYRFQ VEDDIRPFRD ILLGFFFITV GMKLDIQALI GGWRQVLMLL
AMLLVLKALV VFAIAFKMKH SVGDSLKTAL YLAQGGEFGF VMLAIAGQLD MVSPEWEQAA
TAAVLLSMII APFLLGGSDA LVGRLVKSSW DMKSLDLHSM LVETMSKSDH VLIVGFGRGG
QTVGRVLAQE DIPYFALDLD IARVQVARSA GEPVSFGDAK RREVLEAAGL GRAKMVVVTL
NNMHETQHVL DNVLSMYPNM PVYVRATNDD YVKTFTDIGA EEAVSDTKET GLVLAGYAML
GNGASYRHVY QTMANIRHSR YAALEGLFVG SDDEAGFGEN GETVRHAFPL AAEAYAVGKT
VGTLPMAAYG IKLLFVRRRT GRIENPDASF TLEGGDVLVV AGKKEEIISF ENWSLQGI
//
