ID Q9K3H7_STRCO Unreviewed; 295 AA.
AC Q9K3H7;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 130.
DE SubName: Full=ECF-sigma factor {ECO:0000313|EMBL:CAB99143.1};
GN OrderedLocusNames=SCO1263 {ECO:0000313|EMBL:CAB99143.1};
GN ORFNames=2SCG18.10c {ECO:0000313|EMBL:CAB99143.1};
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226 {ECO:0000313|EMBL:CAB99143.1, ECO:0000313|Proteomes:UP000001973};
RN [1] {ECO:0000313|EMBL:CAB99143.1, ECO:0000313|Proteomes:UP000001973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145
RC {ECO:0000313|Proteomes:UP000001973};
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
CC -!- SUBUNIT: Interacts transiently with the RNA polymerase catalytic core
CC formed by RpoA, RpoB, RpoC and RpoZ (2 alpha, 1 beta, 1 beta' and 1
CC omega subunit) to form the RNA polymerase holoenzyme that can initiate
CC transcription. {ECO:0000256|ARBA:ARBA00011344}.
CC -!- SIMILARITY: Belongs to the sigma-70 factor family. ECF subfamily.
CC {ECO:0000256|ARBA:ARBA00010641}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL939108; CAB99143.1; -; Genomic_DNA.
DR RefSeq; NP_625550.1; NC_003888.3.
DR RefSeq; WP_003977567.1; NZ_VNID01000006.1.
DR AlphaFoldDB; Q9K3H7; -.
DR STRING; 100226.gene:17758846; -.
DR PaxDb; 100226-SCO1263; -.
DR PATRIC; fig|100226.15.peg.1263; -.
DR eggNOG; COG1595; Bacteria.
DR HOGENOM; CLU_047691_22_0_11; -.
DR InParanoid; Q9K3H7; -.
DR OrthoDB; 3211555at2; -.
DR PhylomeDB; Q9K3H7; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016987; F:sigma factor activity; IBA:GO_Central.
DR GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR Gene3D; 1.10.1740.10; -; 1.
DR Gene3D; 3.10.450.50; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR032710; NTF2-like_dom_sf.
DR InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR InterPro; IPR014303; RNA_pol_sigma-70_ECF.
DR InterPro; IPR007627; RNA_pol_sigma70_r2.
DR InterPro; IPR013249; RNA_pol_sigma70_r4_t2.
DR InterPro; IPR013325; RNA_pol_sigma_r2.
DR InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR02937; sigma70-ECF; 1.
DR NCBIfam; TIGR02957; SigX4; 1.
DR PANTHER; PTHR30173:SF36; ECF-FAMILY RNA POLYMERASE SIGMA FACTOR-RELATED; 1.
DR PANTHER; PTHR30173; SIGMA 19 FACTOR; 1.
DR Pfam; PF04542; Sigma70_r2; 1.
DR Pfam; PF08281; Sigma70_r4_2; 1.
DR SUPFAM; SSF54427; NTF2-like; 1.
DR SUPFAM; SSF88946; Sigma2 domain of RNA polymerase sigma factors; 1.
DR SUPFAM; SSF88659; Sigma3 and sigma4 domains of RNA polymerase sigma factors; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001973};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 10..73
FT /note="RNA polymerase sigma-70 region 2"
FT /evidence="ECO:0000259|Pfam:PF04542"
FT DOMAIN 112..162
FT /note="RNA polymerase sigma factor 70 region 4 type 2"
FT /evidence="ECO:0000259|Pfam:PF08281"
SQ SEQUENCE 295 AA; 32267 MW; E06F5DAD68315ECA CRC64;
MTTDTATDVF EEHRPVLLGV AYRMLGRLAD AEDVVQEAWL RWSGADRAAV REPRGYLVRV
TTRLAIDRLR QVKSRGETYV GPWLPEPYVT DFGDAVPDTA ERAVLADSVS LAVLVVLESL
SPLERAVFVL REAFGYPYAE IAAMLERGEA AVRQLAGRAR KHVDERRPRY DVDPAQRRDL
TERFLAAAAE GDLAGLLATL APDVRLVGDS GGRSKAPLRV LESSDKVGRF LLGVARQGVP
DATFHFLELN GGPALLVRSG GKPDSVVQVD VVDGRIQSMY IIRNPDKLVS LAGVL
//
