ID Q9K4L9_STRCO Unreviewed; 988 AA.
AC Q9K4L9;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 136.
DE SubName: Full=LuxR-family regulator {ECO:0000313|EMBL:CAB93733.1};
GN OrderedLocusNames=SCO7295 {ECO:0000313|EMBL:CAB93733.1};
GN ORFNames=SC5F8.05c {ECO:0000313|EMBL:CAB93733.1};
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226 {ECO:0000313|EMBL:CAB93733.1, ECO:0000313|Proteomes:UP000001973};
RN [1] {ECO:0000313|EMBL:CAB93733.1, ECO:0000313|Proteomes:UP000001973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145
RC {ECO:0000313|Proteomes:UP000001973};
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL939131; CAB93733.1; -; Genomic_DNA.
DR RefSeq; NP_631350.1; NC_003888.3.
DR RefSeq; WP_011031572.1; NZ_VNID01000019.1.
DR AlphaFoldDB; Q9K4L9; -.
DR STRING; 100226.gene:17764955; -.
DR PaxDb; 100226-SCO7295; -.
DR PATRIC; fig|100226.15.peg.7397; -.
DR eggNOG; COG2197; Bacteria.
DR eggNOG; COG3899; Bacteria.
DR HOGENOM; CLU_006850_0_2_11; -.
DR InParanoid; Q9K4L9; -.
DR OrthoDB; 5476461at2; -.
DR PhylomeDB; Q9K4L9; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0004016; F:adenylate cyclase activity; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd06170; LuxR_C_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR041664; AAA_16.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR16305; TESTICULAR SOLUBLE ADENYLYL CYCLASE; 1.
DR PANTHER; PTHR16305:SF35; TRANSCRIPTIONAL ACTIVATOR DOMAIN; 1.
DR Pfam; PF13191; AAA_16; 1.
DR Pfam; PF00196; GerE; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001973}.
FT DOMAIN 913..978
FT /note="HTH luxR-type"
FT /evidence="ECO:0000259|PROSITE:PS50043"
SQ SEQUENCE 988 AA; 105356 MW; E655EB9390988CD4 CRC64;
MGGVPQTSLT SPLVGREDEL ARLTGVLERA RAGEARAVLV AGDAGVGKTR TLHEAAGRAA
AAGTTVLTGH CVDLGDVGLP YLPFTEILGV LAADERFAAV LAGHPVADRL LGGGPDDGTD
AAPSRLRLFE GVAALLTELA DVAPLLLVLE DLHWADQSSR DLLRFLLGRG VLQRPAGGAP
GHRLALFASY RADDLHRRHP LRPLLAELVR LPGVERLELR PLPDSDVARL VRLLRERRLP
DSTVRRIVER AEGNAFYAEE LVAATDAPAG GVPSGLADVL LIRFEQLSET AQQVLRTAAV
AGRRVGHDLL RDAVGLPEEE LESALREAVE RQLLVSGDGG AYSFRHALAR EAVYADLLPG
ERARLHGAFA RLLAGPDRRS DSAAERAHHY RESHDLPEAL AASLEAADHA QRVGAPAEEL
RHVEAALDLW TAVDAAARPA GPDAVTLTLR ASAAAVHAGE LHRAVSLTRS ALAGLGQDAD
LELAARVRYT LAGNLLSVDN LESAYAYSSE ALGLIPAEPP SSTWVWAAAT HVTAARQVGE
NETALRVARR ALRAAEELAV TDARADLLIS LTSLEGGNRS TPEGRERLLE ARELARRAGN
APVELRALFN LAIGCFESGD LEECLPWASE GLDRARRSGL LSSPYPREMR YLRLLVQYTL
GHWDEVLRES AEHAGERSAV DGHALGPGLY VALARGDSGV ADRARALLNG PFDWMARMVA
GVVLTDAAAL RGDAEDAVRW MRSSVETLTE AGTRPTVTLR LATLALSAVA DTVTELRRAG
DDAGVARWSD TAAELLADAR WSAGHGYDDM PQGPEGQAWL ARAEAEWSRV AGAAPDPAAW
ERAVAAFTYG DTYERARCRL RLADALLAAD RREEAATEAG GVRREADRLG ATVLRERVDD
LVRRGRLAGP ARAGAGAAVL TAREQDVLRL LALGHSNRRI GEELFISAKT ASVHVSNILA
KLNAASRTEA VAVAHRQGLV APEPTSSH
//
