ID Q9KLH2_VIBCH Unreviewed; 400 AA.
AC Q9KLH2;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 109.
DE RecName: Full=Aromatic amino acid permease {ECO:0000256|RuleBase:RU367149};
GN OrderedLocusNames=VC_A0772 {ECO:0000313|EMBL:AAF96670.1};
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277 {ECO:0000313|EMBL:AAF96670.1, ECO:0000313|Proteomes:UP000000584};
RN [1] {ECO:0000313|EMBL:AAF96670.1, ECO:0000313|Proteomes:UP000000584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961
RC {ECO:0000313|Proteomes:UP000000584};
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D., Ermolaeva M.D.,
RA Vamathevan J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.,
RA Utterback T., Fleishmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
CC -!- FUNCTION: Involved in transporting aromatic amino acids across the
CC cytoplasmic membrane. {ECO:0000256|RuleBase:RU367149}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429, ECO:0000256|RuleBase:RU367149}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004429,
CC ECO:0000256|RuleBase:RU367149}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.
CC Mtr/TnaB/TyrP permease subfamily. {ECO:0000256|ARBA:ARBA00005452,
CC ECO:0000256|RuleBase:RU367149}.
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DR EMBL; AE003853; AAF96670.1; -; Genomic_DNA.
DR PIR; D82419; D82419.
DR RefSeq; NP_233158.1; NC_002506.1.
DR RefSeq; WP_000194442.1; NZ_LT906615.1.
DR AlphaFoldDB; Q9KLH2; -.
DR STRING; 243277.VC_A0772; -.
DR DNASU; 2612325; -.
DR EnsemblBacteria; AAF96670; AAF96670; VC_A0772.
DR KEGG; vch:VC_A0772; -.
DR PATRIC; fig|243277.26.peg.3396; -.
DR eggNOG; COG0814; Bacteria.
DR HOGENOM; CLU_038102_3_0_6; -.
DR Proteomes; UP000000584; Chromosome 2.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015173; F:aromatic amino acid transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR018227; Amino_acid_transport_2.
DR InterPro; IPR013061; Trp/try_permease_CS.
DR InterPro; IPR013059; Trp_tyr_transpt.
DR NCBIfam; TIGR00837; araaP; 1.
DR PANTHER; PTHR46997; LOW AFFINITY TRYPTOPHAN PERMEASE-RELATED; 1.
DR PANTHER; PTHR46997:SF2; TYROSINE-SPECIFIC TRANSPORT SYSTEM; 1.
DR Pfam; PF03222; Trp_Tyr_perm; 1.
DR PRINTS; PR00166; AROAAPRMEASE.
DR PROSITE; PS00594; AROMATIC_AA_PERMEASE_1; 1.
PE 3: Inferred from homology;
KW Amino-acid transport {ECO:0000256|ARBA:ARBA00022970,
KW ECO:0000256|RuleBase:RU367149};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519,
KW ECO:0000256|RuleBase:RU367149};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367149};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367149};
KW Reference proteome {ECO:0000313|Proteomes:UP000000584};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367149};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367149};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU367149}.
FT TRANSMEM 6..28
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367149"
FT TRANSMEM 40..62
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367149"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367149"
FT TRANSMEM 123..143
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367149"
FT TRANSMEM 149..170
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367149"
FT TRANSMEM 182..208
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367149"
FT TRANSMEM 214..233
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367149"
FT TRANSMEM 271..294
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367149"
FT TRANSMEM 306..327
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367149"
FT TRANSMEM 333..354
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367149"
FT TRANSMEM 374..399
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367149"
SQ SEQUENCE 400 AA; 42263 MW; 64D10B8216ED8F02 CRC64;
MTQSKLLGST LIIAGTTIGA GMLALPLASA GIGFSTSLMI MLGLWMLMAF TALLMVEIHQ
YADKEATLHT LAKQILGDKG KWVATFAMLF LFYSLCAAYI AGGGAQFTQR ITDFTGVNVE
SSSGTLLFTL IVALVVTVGT GTVDRVNRVL FAGKMIAMVA VLFFLAPNVS QSYLLSMPIQ
QGLIVAAIPV IFTSFGFHGS IPAIVNYLDG DTPALRKAIL IGSAIPLVIY IFWQLVTLGV
VSQSALLDNM GLTALIGVLS TTVHQSNLGN IIGVFADLAL LTSFLGVSLG LFEFMGDSLR
NQQGKMNRPL ASVVTFLPPL IFALFYPQGF IMALGYAAIA LAILAIFLPL VMVIKVRQQA
TEQHYQVTGG NGALLVTGLV GLLIIGAQLL ITLGILPALG
//
