ID Q9KSB8_VIBCH Unreviewed; 632 AA.
AC Q9KSB8;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=PrpE protein {ECO:0000313|EMBL:AAF94498.1};
GN OrderedLocusNames=VC_1340 {ECO:0000313|EMBL:AAF94498.1};
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277 {ECO:0000313|EMBL:AAF94498.1, ECO:0000313|Proteomes:UP000000584};
RN [1] {ECO:0000313|EMBL:AAF94498.1, ECO:0000313|Proteomes:UP000000584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961
RC {ECO:0000313|Proteomes:UP000000584};
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D., Ermolaeva M.D.,
RA Vamathevan J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.,
RA Utterback T., Fleishmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; AE003852; AAF94498.1; -; Genomic_DNA.
DR PIR; D82213; D82213.
DR RefSeq; NP_230984.1; NC_002505.1.
DR AlphaFoldDB; Q9KSB8; -.
DR STRING; 243277.VC_1340; -.
DR DNASU; 2614794; -.
DR EnsemblBacteria; AAF94498; AAF94498; VC_1340.
DR KEGG; vch:VC_1340; -.
DR PATRIC; fig|243277.26.peg.1277; -.
DR eggNOG; COG0365; Bacteria.
DR HOGENOM; CLU_000022_3_6_6; -.
DR Proteomes; UP000000584; Chromosome 1.
DR GO; GO:0050218; F:propionate-CoA ligase activity; IBA:GO_Central.
DR CDD; cd05967; PrpE; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43347; ACYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR43347:SF3; ACYL-COA SYNTHETASE SHORT-CHAIN FAMILY MEMBER 3, MITOCHONDRIAL; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000584}.
FT DOMAIN 11..63
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 72..454
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 517..596
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 632 AA; 70108 MW; 0F4B7EDB946E9838 CRC64;
MRARSNAMSA YQEQYQWAKE QPEAFWRKQA QQIDWFQPPQ TILANDEHGI ERWFPDGVLN
TCWLALDYHC EQGRGDHTAL IYDSPVTGKK QRYSYSALRD SVAKIAGMLA AQGVSKGDRV
IIYMPMIPEA AMAMLACARL GAIHSVVFGG FAPNELAVRI EDAEPKVIMT ASCGVEINKV
IPYKPMVDKA IMDSRWKPEK VLVYQRSECR AELTHARDLE WNTVVQSATP HGCVPVLATD
PLYILYTSGT TGKPKGVVRD NGGHAVALKY SMQIIYNMPQ DGVFWAASDV GWVVGHSYIV
YAPLIHGCTT ILYEGKPVRT PDPGAFWRVC QEYQVTALFS APTAFRAIKK EDPNGDYLKK
YDLSALTTIF MAGERLDPPT LEWVQSKTGK PVIDHWWQTE TGWAIAGNPT GLESMPIKAG
SATKPIPGYQ VEILNELGEN MPANQQGFVA LKRPLPPSCL PTVWRNHDRF ESGYLAQFPG
YYVSGDGGYL DDDGYLFIMG RIDDVINVAG HRLSTGEMEE IVGAHPAVAE CAVIGVHDEL
KGQLPLGLVV LKDGVKIDAQ TLEQELVASV RNQIGAVACF KHAIVVERLP KTRSGKILRR
IIRQIADGES YTIPSTIDDP MSLNELENLF QH
//
