ID Q9KVR7_VIBCH Unreviewed; 768 AA.
AC Q9KVR7;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 116.
DE SubName: Full=Sensory box/GGDEF family protein {ECO:0000313|EMBL:AAF93250.1};
GN OrderedLocusNames=VC_0072 {ECO:0000313|EMBL:AAF93250.1};
OS Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=243277 {ECO:0000313|EMBL:AAF93250.1, ECO:0000313|Proteomes:UP000000584};
RN [1] {ECO:0000313|EMBL:AAF93250.1, ECO:0000313|Proteomes:UP000000584}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 39315 / El Tor Inaba N16961
RC {ECO:0000313|Proteomes:UP000000584};
RX PubMed=10952301; DOI=10.1038/35020000;
RA Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA Nelson K.E., Read T.D., Tettelin H., Richardson D., Ermolaeva M.D.,
RA Vamathevan J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.,
RA Utterback T., Fleishmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT cholerae.";
RL Nature 406:477-483(2000).
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DR EMBL; AE003852; AAF93250.1; -; Genomic_DNA.
DR PIR; H82367; H82367.
DR RefSeq; NP_229731.1; NC_002505.1.
DR AlphaFoldDB; Q9KVR7; -.
DR STRING; 243277.VC_0072; -.
DR DNASU; 2612952; -.
DR EnsemblBacteria; AAF93250; AAF93250; VC_0072.
DR KEGG; vch:VC_0072; -.
DR PATRIC; fig|243277.26.peg.70; -.
DR eggNOG; COG2199; Bacteria.
DR eggNOG; COG2200; Bacteria.
DR eggNOG; COG2202; Bacteria.
DR HOGENOM; CLU_000445_70_20_6; -.
DR Proteomes; UP000000584; Chromosome 1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd01948; EAL; 1.
DR CDD; cd01949; GGDEF; 1.
DR CDD; cd00130; PAS; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.20.20.450; EAL domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR001633; EAL_dom.
DR InterPro; IPR035919; EAL_sf.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR NCBIfam; TIGR00254; GGDEF; 1.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR44757:SF11; DIGUANYLATE CYCLASE DGCE-RELATED; 1.
DR PANTHER; PTHR44757; DIGUANYLATE CYCLASE DGCP; 1.
DR Pfam; PF00563; EAL; 1.
DR Pfam; PF00990; GGDEF; 1.
DR Pfam; PF13426; PAS_9; 1.
DR SMART; SM00052; EAL; 1.
DR SMART; SM00267; GGDEF; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF141868; EAL domain-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50883; EAL; 1.
DR PROSITE; PS50887; GGDEF; 1.
DR PROSITE; PS50112; PAS; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000584};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 57..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 214..269
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 368..501
FT /note="GGDEF"
FT /evidence="ECO:0000259|PROSITE:PS50887"
FT DOMAIN 512..767
FT /note="EAL"
FT /evidence="ECO:0000259|PROSITE:PS50883"
SQ SEQUENCE 768 AA; 88089 MW; 3EE2F1E1E886CADF CRC64;
MESDLSRLRH WYNKYALPLA VGLGCFWTAN LVAQEPTLSS QPLDNLGTSR VPWDSELAAN
AMLWIVALVA IMVLSILTVR QYHYIQRLRT NQKLLESIFD QSTHYIGIFD LEGRIISCNG
KLQGLLYRHG ESLLRPIWQH KGWEDSAVEH IQNYFSESVP QTRQFNAEIW HPELGAIVLE
CQFKPLPTRE ESQILLEAQD ITWRKITEDK LFQREASLRH YYDQQPVMML TLDERNHIQQ
VNHFAEQLLG YPADVMLGHH IRDFYQDEEV LTPRQMLLLP SRHASSVWRR EVCYRHHSGE
TVWVRENIRP LVETGTLLIV GEDITETRQL ADQLAYQARY DLLTHTLNRN QFELELAKAL
KETDSQLRTH AMLYLDLDQL KVLNDTAGHD AGDGAIQFCA SMLEDVLPFK ATLARMGGDE
FSVLLRDCTE RDAVLVAQSI IHALSEVAFV WEHIRFNLTC SIGIRMIDHT ATSPQMVHAQ
ADTACHAAKE EGRNRFNLYR QDDEDLRRRQ LEMESVNLVH DALANERIEL FAQRIVPLNQ
PDVLLHFEVL VRIKNAAGEY VSPGIFVPAS ERYNLAHRLD RKIVEQTFNW LEARPQVLDK
LGRVSINLSG NSIGNPDFVA FLLERLRDSR IPCSKVCFEI TETAAMRNLN QAIKVLSQLK
SLGCVLALDD FGSGLSSFGY LQKLPVDIVK IDGIFVCDMD KNEMDRLMVR SIHELTKQMG
KSTVAEFVEN QQILEALQQI GVDYAQGYLF SRPQPIADWV AEQLKEKA
//
