ID Q9KYF4_STRCO Unreviewed; 1114 AA.
AC Q9KYF4;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 151.
DE SubName: Full=AfsR-like regulatory protein {ECO:0000313|EMBL:CAB92369.1};
GN OrderedLocusNames=SCO4116 {ECO:0000313|EMBL:CAB92369.1};
GN ORFNames=SCD72A.02 {ECO:0000313|EMBL:CAB92369.1};
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226 {ECO:0000313|EMBL:CAB92369.1, ECO:0000313|Proteomes:UP000001973};
RN [1] {ECO:0000313|EMBL:CAB92369.1, ECO:0000313|Proteomes:UP000001973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145
RC {ECO:0000313|Proteomes:UP000001973};
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
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DR EMBL; AL939118; CAB92369.1; -; Genomic_DNA.
DR RefSeq; NP_628294.1; NC_003888.3.
DR AlphaFoldDB; Q9KYF4; -.
DR STRING; 100226.gene:17761757; -.
DR PaxDb; 100226-SCO4116; -.
DR PATRIC; fig|100226.15.peg.4177; -.
DR eggNOG; COG3629; Bacteria.
DR eggNOG; COG3903; Bacteria.
DR HOGENOM; CLU_004665_1_3_11; -.
DR InParanoid; Q9KYF4; -.
DR OrthoDB; 499349at2; -.
DR PhylomeDB; Q9KYF4; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd15831; BTAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR47691:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED; 1.
DR PANTHER; PTHR47691; REGULATOR-RELATED; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00028; TPR; 2.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU01091};
KW Reference proteome {ECO:0000313|Proteomes:UP000001973};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 2..102
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 2..102
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
FT REGION 248..271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1049..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1053..1068
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1114 AA; 118781 MW; 4BB3F939C6574305 CRC64;
MPAPHRCGDN DSVRYRILGV TQTEDHGTVV NPGGPRLRAL LTALALRPGD VVTPTTLIDE
VWAEDDPPQD APAALQALVG RLRRTVGKDA VASAPGGYRL AATRDDVDLF VFERLVRRGT
AALAHGDAAT AARHLDEALA LWRGPALADL PGHAARPDAL RLEATRARIE AGLRLGDAHD
AVPRLRELTA AHPYDEPLHA LLIAALRAAG RDADALAAYE SARRTLADGL GTEPGPRLRA
LHAELLGTGG AQRPSPAPGR APSDGRKGNI RPRLTTFVGR EPELDALRSE LPGARLVTLT
GPGGSGKTRL AEEAAAGLDQ AWLVELAPLD RPEAVPGAIV NALGLRETVL LTGDRPAGQD
DPVALLVEYC APRSQLLVLD NCEHVIGAAA RLVETLLTRC PGLTVLATSR EPLGVPGESV
RPVEPLTQEQ AQRLFTARAG AVRPDADAVL RDEEAVAEIC RRLDGLPLAI ELAAARLRLL
TPREIADRLD DRFRLLTSGS RTVLPRQQTL RAVVDWSWDL LDEAERTLLR ELSVFAGGWD
LAAAEAVGTG PAADLLGALV DKSLVVADPG ADGAAMRYRL LETIHEYAGE RAAETPGLRD
AAERAHRAWA RTLAQEADAQ LRSAGQLPYI SRLEDEHDNI RAALDRSLAA GDEPEAAALA
LAMGWFWWLR NYRHEGVRWL ERVLRLGAAL DAGGGERVPG ADVLARRTAA ADHVGALLEG
SGGGSGHPLH ALRMQVRMMH ILLTFETAPR EGLLDERMRR YVRRVRDHFA AGGPEAARVP
GLIWPLTEFF VSDSGDVQGS MDASVANCRV YGGEWEIAAS LMFRTHAVVD ISGTPVGIDA
DLAEMRVLSR RVGDRLVEAQ VCSAFGEAAM VRGRYEEARA EYAEALRLAE EVGAFAEAPF
LIARLAEIAY REGDHGTALG VLDKAGAAAD RYGVVDSKAF VLMLRAGLAV ADEEFARARV
LWEAAREECL RGTPPPQFLA MLGLVDALVT AGESGPGAAL PLLTGTLRTA VEERCAELVL
ATLADSAAGL LSDLGDQARA VRLLGAAGHW RGDRPRPMPD RAHAERAEAA ARGALGPQRY
AAEVAAGAGL TPGDVVGELE TAVRRPVPQA PTRR
//
