ID Q9KZ42_STRCO Unreviewed; 748 AA.
AC Q9KZ42;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 105.
DE SubName: Full=Integral membrane protein {ECO:0000313|EMBL:CAB89762.1};
GN OrderedLocusNames=SCO7090 {ECO:0000313|EMBL:CAB89762.1};
GN ORFNames=SC3A4.16c {ECO:0000313|EMBL:CAB89762.1};
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226 {ECO:0000313|EMBL:CAB89762.1, ECO:0000313|Proteomes:UP000001973};
RN [1] {ECO:0000313|EMBL:CAB89762.1, ECO:0000313|Proteomes:UP000001973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145
RC {ECO:0000313|Proteomes:UP000001973};
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AL939130; CAB89762.1; -; Genomic_DNA.
DR RefSeq; NP_631151.1; NC_003888.3.
DR RefSeq; WP_011031424.1; NZ_VNID01000012.1.
DR AlphaFoldDB; Q9KZ42; -.
DR STRING; 100226.gene:17764750; -.
DR PaxDb; 100226-SCO7090; -.
DR PATRIC; fig|100226.15.peg.7192; -.
DR eggNOG; COG2409; Bacteria.
DR HOGENOM; CLU_005108_1_1_11; -.
DR InParanoid; Q9KZ42; -.
DR OrthoDB; 7051771at2; -.
DR PhylomeDB; Q9KZ42; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001973};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 181..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 208..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..252
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 532..551
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 563..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 602..623
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 644..663
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 675..700
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 198..330
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 725..748
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 748 AA; 77522 MW; 63D5C8BF463A8C84 CRC64;
MATFLYRLGR TAFRRRWLVT LLWVVVLGGV GLGAAKAPAA GDDGTSFMPG IEAQKAFDLI
GERFPGSDAN GAHARVVFIA PDGEKVTAGD YRMAVDELVS TVAEGAQVDS AVDPFKADAV
SKDASTAYAT VNYKVKADDL TDASKDGLEK AVDQARGSGL TVEVGGTALA SQPAAGGSAE
AIGIALAAVV LLITFGSLAA AGLPLLTAVI GVGVSMCAIL ALGSTLGLTM TTGTLASMLG
LAVGIDYALF VVSRYREERA NGHAPREAAG LAVGTAGSAV VFAGLTVIIA LVGLTVIGVP
MLTKMGLCAA GAVAIAVLVA LTLVPALLGM WPNAVLSRRV RKFREADKRD GNAKHHSETP
DNGGTRWARF VMRRPVAVLL LGVAVLGVLA LPATHLEMGM PGDEAKPTST TERRAYDALA
DGFGAGFNGP LTVVADVKDA TDPQAAAATM AEQIKDTDGV VSVTPPQFNE AGDTALFSAV
PATGPNTEAT KEIVQTIRAE RPGLEADTGA TFEVTGSTAM NIDVAQALQD ALVPYLAVIV
LLSLLLLLIV FRSILVPVKA ALGFLLSVLA SLGTVVAVFQ WGWGAGLLGV EQTGPIMSLM
PIFLVGIVFG LAMDYEVFLV ARMREAYVHG ERPGQAVVTG FRHSARVVAA AAVIMMAVFS
GFIGSGESMI KTIGFGLAVA VLFDAFVVRM ALVPAVLALL GEKAWWLPRW LDRVLPRVDV
EGTALTSQTR PSTSVDVEEH AQEPARTL
//
