ID Q9L2I4_STRCO Unreviewed; 1472 AA.
AC Q9L2I4;
DT 01-OCT-2000, integrated into UniProtKB/TrEMBL.
DT 01-OCT-2000, sequence version 1.
DT 27-MAR-2024, entry version 159.
DE SubName: Full=Transport ATPase {ECO:0000313|EMBL:CAB69720.1};
GN OrderedLocusNames=SCO2499 {ECO:0000313|EMBL:CAB69720.1};
GN ORFNames=SCC121.02c {ECO:0000313|EMBL:CAB69720.1};
OS Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces; Streptomyces albidoflavus group.
OX NCBI_TaxID=100226 {ECO:0000313|EMBL:CAB69720.1, ECO:0000313|Proteomes:UP000001973};
RN [1] {ECO:0000313|EMBL:CAB69720.1, ECO:0000313|Proteomes:UP000001973}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-471 / A3(2) / M145
RC {ECO:0000313|Proteomes:UP000001973};
RX PubMed=12000953; DOI=10.1038/417141a;
RA Bentley S.D., Chater K.F., Cerdeno-Tarraga A.M., Challis G.L.,
RA Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.H.,
RA Kieser T., Larke L., Murphy L., Oliver K., O'Neil S., Rabbinowitsch E.,
RA Rajandream M.A., Rutherford K., Rutter S., Seeger K., Saunders D.,
RA Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA Woodward J., Barrell B.G., Parkhill J., Hopwood D.A.;
RT "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT A3(2).";
RL Nature 417:141-147(2002).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001836};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AL939112; CAB69720.1; -; Genomic_DNA.
DR RefSeq; NP_626739.1; NC_003888.3.
DR RefSeq; WP_011028388.1; NZ_VNID01000001.1.
DR STRING; 100226.gene:17760101; -.
DR PaxDb; 100226-SCO2499; -.
DR PATRIC; fig|100226.15.peg.2544; -.
DR eggNOG; COG0474; Bacteria.
DR HOGENOM; CLU_002360_0_1_11; -.
DR InParanoid; Q9L2I4; -.
DR OrthoDB; 9814270at2; -.
DR PhylomeDB; Q9L2I4; -.
DR Proteomes; UP000001973; Chromosome.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005388; F:P-type calcium transporter activity; IBA:GO_Central.
DR Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR Gene3D; 1.20.1110.10; Calcium-transporting ATPase, transmembrane domain; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR006068; ATPase_P-typ_cation-transptr_C.
DR InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR InterPro; IPR018303; ATPase_P-typ_P_site.
DR InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR001757; P_typ_ATPase.
DR InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR NCBIfam; TIGR01494; ATPase_P-type; 2.
DR PANTHER; PTHR42861; CALCIUM-TRANSPORTING ATPASE; 1.
DR PANTHER; PTHR42861:SF31; PLASMA MEMBRANE ATPASE-RELATED; 1.
DR Pfam; PF00689; Cation_ATPase_C; 1.
DR Pfam; PF00122; E1-E2_ATPase; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR PRINTS; PR00119; CATATPASE.
DR PRINTS; PR00120; HATPASE.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00027; p-type_atpase; 1.
DR SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR PROSITE; PS00154; ATPASE_E1_E2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000001973};
KW Translocase {ECO:0000256|ARBA:ARBA00022967};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 1290..1443
FT /note="Cation-transporting P-type ATPase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00689"
FT REGION 157..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1472 AA; 151650 MW; A71389768FE4D28A CRC64;
MAGGLLTRSQ DAVTGFVLAG PRLLARGTAP AVGAAAGAAA GTARAGVRGA DFAARAARVA
RAALPGGSRD WRAGPRAHLA LRPVARDEVR RAGGTERVGR RVAAALAEHP DVLFAYWDTG
LARLVVTATE DALTDRVVDH ATELAGRHGL TRVDQADLTG LTGPGEPGDD DLVDGDLVDE
PDHPGDPAPV RVAAAALGAD VLGIAAAVTG ARLRLPPSPR LVTAVATLLR ENPAFRAWLR
ERLGDHRMDV ALAAANAAVH GAGQSPTSLV LDGALRVCQL TEAVARGAAF EVVHDRLCVP
GRDSLPAVPA LRPAPRTSPA QDYAAHASAG SVAGAAATLL VKHDLAEAAE AVLAGSPKAA
RYGPAAFHAV LSAALSRTGV LVRDPGRLRQ LEMVRTVVLH PSALRVPDAG ADPWTEDVLD
AARRAGLRVV MVEDPALADF TGLADQVVGA RRPLADVVAE LRAEGGVVTV VRPLPGDDGS
VSAGLLAGDV AVALADGDCP VAWGADVLAP QGLADVWRVL RAVPVARAVG RRSQTLARSG
AALSGLLVAV GEARGRSRGG VSSLLGMRHA PVDASAALAL LSGTRAAIGV ATARAPHPRA
RVAWHALDPQ DVRDRLERER EPEPTAVEQA TARLRAAADR AGRVPVLAPV RWSWQLARAV
RGELDDPLTP VLAVGSAASA ILGSVVDALL VVGALDLNAL VGGFQRLRAE RALSGLLAEQ
KQKARVAEEQ LRPETAEFTP EGEPRIVDAA KLHPGHVIEL RADDVVPADA RLLWEDGLEV
DESALTGESL PVDKCVDPAP RAPVAERYCM VFEGTTVVAG RARAVVVDTG DHTEAARAVA
LAARTPSAAG VQARLQELTR KALPLTLAGG AAVTGLSLLR GAPIRQAVAG GVSVAVAAVP
EGLPLVATVA QLAAARRLSR RGVLVRTPRT LEALGRMDTV CFDKTGTLTE NRLRLSRVAG
ADGTVRRSGD PETADTVRTA ARACPRLDGD GARPTHATDE AILDAAGDDP GWTQEEGLPF
ETSRGYAAAV GREDGTGAAV LVVKGAPETV LPACAGLPDH ALEVAQRLAG AGLRIIAVAR
RTLDTGERAA DVLERQPSEL EFTGLLALAD VARETSPALV RGLREAGVRP VVLTGDHPQT
AHAIAVDLGW PEDAVVVTGD ELAAADRTAR SRMLRDADVV ARVAPEQKLQ VVESLRDAGR
VVGMVGDGAN DAAAIRAADI GVGISARGSA AARNAADLVV TGDDLLVLVE AVREGRALWH
SVADAIAILI GGNAGEVGFG ILGTVLGGAA PLSTRQMLLV NLFTDLFPAM AVAVTKTGDP
EQEAADAGAP LGTAVLGEPL IRQIRHRALT TALGATAAWL LGRFTPGTRR RSTTMALCAV
VGTQLAQTLA DRRDSRLVQV TSLGSAAALV ALVQTPGASR LFGCTPLGPV AWTCVAAAIA
LALAGQRALP GVEDAIVRYW PKAAERLPRA VR
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