GenomeNet

Database: UniProt
Entry: Q9M658
LinkDB: Q9M658
Original site: Q9M658 
ID   MOM1_ARATH              Reviewed;        2001 AA.
AC   Q9M658; Q8GXZ0; Q9LN02; Q9M659;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   16-OCT-2019, entry version 90.
DE   RecName: Full=Helicase protein MOM1;
DE            EC=3.6.4.-;
DE   AltName: Full=Protein MAINTENANCE OF METHYLATION;
DE   AltName: Full=Protein MORPHEUS MOLECULE 1;
GN   Name=MOM1; Synonyms=MOM; OrderedLocusNames=At1g08060;
GN   ORFNames=T6D22.14;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae;
OC   Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
OC   Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, DISRUPTION
RP   PHENOTYPE, AND SUBCELLULAR LOCATION.
RC   STRAIN=cv. Columbia, and cv. Zurich;
RX   PubMed=10821279; DOI=10.1038/35012108;
RA   Amedeo P., Habu Y., Afsar K., Mittelsten Scheid O., Paszkowski J.;
RT   "Disruption of the plant gene MOM releases transcriptional silencing
RT   of methylated genes.";
RL   Nature 405:203-206(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S.,
RA   White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y.,
RA   Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W.,
RA   Chung M.K., Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K.,
RA   Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y.,
RA   Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L.,
RA   Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E.,
RA   Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B.,
RA   Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P.,
RA   Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A.,
RA   Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I.,
RA   Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D.,
RA   Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M.,
RA   Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M.,
RA   Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis
RT   thaliana.";
RL   Nature 408:816-820(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana
RT   reference genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1756-2001.
RC   STRAIN=cv. Columbia;
RX   PubMed=11910074; DOI=10.1126/science.1071006;
RA   Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA   Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M.,
RA   Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T.,
RA   Shibata K., Shinagawa A., Shinozaki K.;
RT   "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL   Science 296:141-145(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1769-2001.
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
RA   Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
RA   Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
RA   Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
RA   Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
RA   Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
RA   Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
RA   Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
RA   Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
RA   Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
RA   Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
RA   Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
RN   [6]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=10899982; DOI=10.1105/tpc.12.7.1165;
RA   Steimer A., Amedeo P., Afsar K., Fransz P., Mittelsten Scheid O.,
RA   Paszkowski J.;
RT   "Endogenous targets of transcriptional gene silencing in
RT   Arabidopsis.";
RL   Plant Cell 12:1165-1178(2000).
RN   [7]
RP   REVIEW.
RX   PubMed=10999407; DOI=10.1023/a:1006487529698;
RA   Mittelsten Scheid O., Paszkowski J.;
RT   "Transcriptional gene silencing mutants.";
RL   Plant Mol. Biol. 43:235-241(2000).
RN   [8]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=12370435; DOI=10.1073/pnas.202380499;
RA   Mittelsten Scheid O., Probst A.V., Afsar K., Paszkowski J.;
RT   "Two regulatory levels of transcriptional gene silencing in
RT   Arabidopsis.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:13659-13662(2002).
RN   [9]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=12609046; DOI=10.1046/j.1365-313x.2003.01667.x;
RA   Probst A.V., Fransz P.F., Paszkowski J., Mittelsten Scheid O.;
RT   "Two means of transcriptional reactivation within heterochromatin.";
RL   Plant J. 33:743-749(2003).
RN   [10]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=17082821; DOI=10.1038/sj.embor.7400791;
RA   Vaillant I., Schubert I., Tourmente S., Mathieu O.;
RT   "MOM1 mediates DNA-methylation-independent silencing of repetitive
RT   sequences in Arabidopsis.";
RL   EMBO Rep. 7:1273-1278(2006).
RN   [11]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=17082818; DOI=10.1038/sj.embor.7400835;
RA   Habu Y., Mathieu O., Tariq M., Probst A.V., Smathajitt C., Zhu T.,
RA   Paszkowski J.;
RT   "Epigenetic regulation of transcription in intermediate
RT   heterochromatin.";
RL   EMBO Rep. 7:1279-1284(2006).
RN   [12]
RP   CMM REGIONS, FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=18725928; DOI=10.1371/journal.pgen.1000165;
RA   Caikovski M., Yokthongwattana C., Habu Y., Nishimura T., Mathieu O.,
RA   Paszkowski J.;
RT   "Divergent evolution of CHD3 proteins resulted in MOM1 refining
RT   epigenetic control in vascular plants.";
RL   PLoS Genet. 4:E1000165-E1000165(2008).
RN   [13]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=19910926; DOI=10.1038/emboj.2009.328;
RA   Yokthongwattana C., Bucher E., Caikovski M., Vaillant I., Nicolet J.,
RA   Mittelsten Scheid O., Paszkowski J.;
RT   "MOM1 and Pol-IV/V interactions regulate the intensity and specificity
RT   of transcriptional gene silencing.";
RL   EMBO J. 29:340-351(2010).
RN   [14]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=21070421; DOI=10.1111/j.1365-313x.2010.04358.x;
RA   Mlotshwa S., Pruss G.J., Gao Z., Mgutshini N.L., Li J., Chen X.,
RA   Bowman L.H., Vance V.;
RT   "Transcriptional silencing induced by Arabidopsis T-DNA mutants is
RT   associated with 35S promoter siRNAs and requires genes involved in
RT   siRNA-mediated chromatin silencing.";
RL   Plant J. 64:699-704(2010).
RN   [15]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=20826701; DOI=10.1104/pp.110.162131;
RA   Zhou Y., Zhang J., Lin H., Guo G., Guo Y.;
RT   "MORPHEUS' MOLECULE1 is required to prevent aberrant RNA
RT   transcriptional read-through in Arabidopsis.";
RL   Plant Physiol. 154:1272-1280(2010).
RN   [16]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=20404545; DOI=10.4161/psb.5.6.11663;
RA   Habu Y., Yoshikawa M.;
RT   "Locus-specific dependency of endogenous silent loci on MOM1 and non-
RT   CG methylation in Arabidopsis thaliana.";
RL   Plant Signal. Behav. 5:724-726(2010).
CC   -!- FUNCTION: Required for the heritable maintenance of
CC       transcriptional gene silencing (TGS) in heterochromatin, and
CC       particularly in the intermediate bivalent heterochromatin,
CC       characterized by an unsual methylation pattern consisting in
CC       hypermethylated DNA and histone H3 'Lys-4' methylation (H3K4me)
CC       together with depletion of histone H3 'Lys-9' methylation
CC       (H3K9me), in a chromatin methylation-independent manner, in a non-
CC       CG methylation context. May play a role in the RNA polymerase IV/V
CC       (Pol-IV/V)-mediated RNA-directed DNA methylation (RdDM) leading to
CC       TGS (also called siRNA-mediated TGS pathway), probably by
CC       modulating small interfering RNA (siRNA) accumulation. Especially
CC       involved in the gene silencing of the transcriptionally silent
CC       information region (TSI), 5S ribosomal RNA genes (localized in the
CC       pericentromeric heterochromatin of chromosomes 3, 4, and 5) and of
CC       180-bp satellite repeats and 106B long terminal repeat (LTR)-like
CC       repeats of the chromocenters. Prevents the aberrant mRNA
CC       transcriptional read-through. {ECO:0000269|PubMed:10821279,
CC       ECO:0000269|PubMed:10899982, ECO:0000269|PubMed:12370435,
CC       ECO:0000269|PubMed:12609046, ECO:0000269|PubMed:17082818,
CC       ECO:0000269|PubMed:17082821, ECO:0000269|PubMed:18725928,
CC       ECO:0000269|PubMed:19910926, ECO:0000269|PubMed:20404545,
CC       ECO:0000269|PubMed:20826701, ECO:0000269|PubMed:21070421}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10821279}.
CC   -!- DISRUPTION PHENOTYPE: Reactivated transcription of heavily
CC       methylated silent loci, independently of chromatin demethylation.
CC       Releases TSI, 5S ribosomal RNA genes as well as 180-bp and 106B
CC       repeats of chromocenters silencing independently of chromatin
CC       properties. Partial derepression of 35S promoter homology-
CC       dependent TGS in transgenic plants. Abnormal aberrant mRNA
CC       transcriptional read-through. Increased expression of minor 5S
CC       rRNA species. No nuclear organization alteration.
CC       {ECO:0000269|PubMed:10821279, ECO:0000269|PubMed:10899982,
CC       ECO:0000269|PubMed:12370435, ECO:0000269|PubMed:12609046,
CC       ECO:0000269|PubMed:17082818, ECO:0000269|PubMed:17082821,
CC       ECO:0000269|PubMed:18725928, ECO:0000269|PubMed:19910926,
CC       ECO:0000269|PubMed:20404545, ECO:0000269|PubMed:20826701,
CC       ECO:0000269|PubMed:21070421}.
CC   -!- MISCELLANEOUS: Requires for the complete maintenance of the 35S
CC       promoter homology-dependent TGS induced by T-DNA construct
CC       insertion.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF79839.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=BAC42596.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
DR   EMBL; AF213627; AAF73380.1; -; mRNA.
DR   EMBL; AF213628; AAF73381.1; -; Genomic_DNA.
DR   EMBL; AC026875; AAF79839.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE28236.1; -; Genomic_DNA.
DR   EMBL; CP002684; AEE28237.1; -; Genomic_DNA.
DR   EMBL; AK117959; BAC42596.1; ALT_INIT; mRNA.
DR   EMBL; BT006219; AAP12868.1; -; mRNA.
DR   PIR; D86215; D86215.
DR   RefSeq; NP_563806.1; NM_100680.4.
DR   RefSeq; NP_849608.1; NM_179277.1.
DR   PDB; 3VEM; X-ray; 3.20 A; A/B/C/D=1700-1814.
DR   PDBsum; 3VEM; -.
DR   SMR; Q9M658; -.
DR   BioGrid; 22563; 7.
DR   IntAct; Q9M658; 4.
DR   STRING; 3702.AT1G08060.1; -.
DR   iPTMnet; Q9M658; -.
DR   PaxDb; Q9M658; -.
DR   PRIDE; Q9M658; -.
DR   EnsemblPlants; AT1G08060.1; AT1G08060.1; AT1G08060.
DR   EnsemblPlants; AT1G08060.2; AT1G08060.2; AT1G08060.
DR   GeneID; 837322; -.
DR   Gramene; AT1G08060.1; AT1G08060.1; AT1G08060.
DR   Gramene; AT1G08060.2; AT1G08060.2; AT1G08060.
DR   KEGG; ath:AT1G08060; -.
DR   Araport; AT1G08060; -.
DR   TAIR; locus:2205205; AT1G08060.
DR   eggNOG; KOG0384; Eukaryota.
DR   eggNOG; COG0553; LUCA.
DR   HOGENOM; HOG000153248; -.
DR   InParanoid; Q9M658; -.
DR   OMA; NIFWTKL; -.
DR   OrthoDB; 90545at2759; -.
DR   PhylomeDB; Q9M658; -.
DR   PRO; PR:Q9M658; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; Q9M658; baseline and differential.
DR   Genevisible; Q9M658; AT.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042803; F:protein homodimerization activity; IPI:TAIR.
DR   GO; GO:0006342; P:chromatin silencing; IMP:TAIR.
DR   GO; GO:0042742; P:defense response to bacterium; IMP:TAIR.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0006344; P:maintenance of chromatin silencing; IMP:UniProtKB.
DR   GO; GO:0045814; P:negative regulation of gene expression, epigenetic; IMP:TAIR.
DR   InterPro; IPR039322; MOM1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR35116; PTHR35116; 3.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   1: Evidence at protein level;
KW   2Fe-2S; 3D-structure; ATP-binding; Coiled coil; Complete proteome;
KW   Helicase; Hydrolase; Iron; Iron-sulfur; Metal-binding;
KW   Nucleotide-binding; Nucleus; Reference proteome;
KW   RNA-mediated gene silencing; Transcription; Transcription regulation.
FT   CHAIN         1   2001       Helicase protein MOM1.
FT                                /FTId=PRO_0000405275.
FT   DOMAIN      357    448       2Fe-2S ferredoxin-type.
FT   DOMAIN      563    722       Helicase C-terminal.
FT   REGION      953   1044       Conserved MOM1 Motif 1 (CMM1).
FT   REGION     1734   1815       Conserved MOM1 Motif 2 (CMM2), required
FT                                to mediates gene silencing maintenance.
FT   REGION     1993   2001       Conserved MOM1 Motif 3 (CMM3).
FT   COILED      693    722       {ECO:0000255}.
FT   COILED     1130   1168       {ECO:0000255}.
FT   COILED     1194   1217       {ECO:0000255}.
FT   COILED     1736   1785       {ECO:0000255}.
FT   COMPBIAS   1858   1962       Pro-rich.
FT   COMPBIAS   1973   1982       Poly-Gln.
FT   METAL       400    400       Iron-sulfur (2Fe-2S). {ECO:0000250}.
FT   METAL       409    409       Iron-sulfur (2Fe-2S). {ECO:0000250}.
FT   METAL       412    412       Iron-sulfur (2Fe-2S). {ECO:0000250}.
FT   METAL       430    430       Iron-sulfur (2Fe-2S). {ECO:0000250}.
FT   CONFLICT    705    705       K -> M (in Ref. 1; AAF73380).
FT                                {ECO:0000305}.
FT   CONFLICT   1219   1219       D -> E (in Ref. 1; AAF73380).
FT                                {ECO:0000305}.
FT   HELIX      1735   1807       {ECO:0000244|PDB:3VEM}.
FT   TURN       1808   1812       {ECO:0000244|PDB:3VEM}.
SQ   SEQUENCE   2001 AA;  218569 MW;  B9C85D4E62704441 CRC64;
     MKKDEKIGLT GRTIYTRSLA ASIPASVEQE TPGLRRSSRG TPSTKVITPA SATRKSERLA
     PSPASVSKKS GGIVKNSTPS SLRRSNRGKT EVSLQSSKGS DNSIRKGDTS PDIEQRKDSV
     EESTDKIKPI MSARSYRALF RGKLKESEAL VDASPNEEEL VVVGCSRRIP AGNDDVQGKT
     DCPPPADAGS KRLPVDETSL DKGTDFPLKS VTETEKIVLD ASPIVETGDD SVIGSPSENL
     ETQKLQDGKT DCSPPANAES KTLPVGETSL EKEYPQKFQD DNTDCLPPAN AESKRLPVGE
     TSLEKDTDFP LKSTTETGKM VLYASPIVET RDDSVICSPS TNLETQKLLV SKTGLETDIV
     LPLKRKRDTA EIELDACATV ANGDDHVMSS DGVIPSPSGC KNDNRPEMCN TCKKRQKVNG
     DCQNRSVCSC IVQPVEESDN VTQDMKETGP VTSREYEENG QIQHGKSSDP KFYSSVYPEY
     WVPVQLSDVQ LEQYCQTLFS KSLSLSSLSK IDLGALEETL NSVRKTCDHP YVMDASLKQL
     LTKNLELHEI LDVEIKASGK LHLLDKMLTH IKKNGLKAVV FYQATQTPEG LLLGNILEDF
     VGQRFGPKSY EHGIYSSKKN SAINNFNKES QCCVLLLETR ACSQTIKLLR ADAFILFGSS
     LNPSHDVKHV EKIKIESCSE RTKIFRLYSV CTVEEKALIL ARQNKRQNKA VENLNRSLTH
     ALLMWGASYL FDKLDHFHSS ETPDSGVSFE QSIMDGVIHE FSSILSSKGG EENEVKLCLL
     LEAKHAQGTY SSDSTLFGED HIKLSDEESP NIFWSKLLGG KNPMWKYPSD TPQRNRKRVQ
     YFEGSEASPK TGDGGNAKKR KKASDDVTDP RVTDPPVDDD ERKASGKDHM GALESPKVIT
     LQSSCKSSGT DGTLDGNDAF GLYSMGSHIS GIPEDMLASQ DWGKIPDESQ RRLHTVLKPK
     MAKLCQVLHL SDACTSMVGN FLEYVIENHR IYEEPATTFQ AFQIALSWIA ALLVKQILSH
     KESLVRANSE LAFKCSRVEV DYIYSILSCM KSLFLEHTQG LQFDCFGTNS KQSVVSTKLV
     NESLSGATVR DEKINTKSMR NSSEDEECMT EKRCSHYSTA TRDIEKTISG IKKKYKKQVQ
     KLVQEHEEKK MELLNMYADK KQKLETSKSV EAAVIRITCS RTSTQVGDLK LLDHNYERKF
     DEIKSEKNEC LKSLEQMHDV AKKKLAEDEA CWINRIKSWA AKLKVCVPIQ SGNNKHFSGS
     SNISQNAPDV QICNNANVEA TYADTNCMAS KVNQVPEAEN TLGTMSGGST QQVHEMVDVR
     NDETMDVSAL SREQLTKSQS NEHASITVPE ILIPADCQEE FAALNVHLSE DQNCDRITSA
     ASDEDVSSRV PEVSQSLENL SASPEFSLNR EEALVTTENR RTSHVGFDTD NILDQQNRED
     CSLDQEIPDE LAMPVQHLAS VVETRGAAES DQYGQDICPM PSSLAGKQPD PAANTESENL
     EEAIEPQSAG SETVETTDFA ASHQGDQVTC PLLSSPTGNQ PAPEANIEGQ NINTSAEPHV
     AGPDAVESGD YAVIDQETMG AQDACSLPSG SVGTQSDLGA NIEGQNVTTV AQLPTDGSDA
     VVTGGSPVSD QCAQDASPMP LSSPGNHPDT AVNIEGLDNT SVAEPHISGS DACEMEISEP
     GPQVERSTFA NLFHEGGVEH SAGVTALVPS LLNNGTEQIA VQPVPQIPFP VFNDPFLHEL
     EKLRRESENS KKTFEEKKSI LKAELERKMA EVQAEFRRKF HEVEAEHNTR TTKIEKDKNL
     VIMNKLLANA FLSKCTDKKV SPSGAPRGKI QQLAQRAAQV SALRNYIAPQ QLQASSFPAP
     ALVSAPLQLQ QSSFPAPGPA PLQPQASSFP SSVSRPSALL LNFAVCPMPQ PRQPLISNIA
     PTPSVTPATN PGLRSPAPHL NSYRPSSSTP VATATPTSSV PPQALTYSAV SIQQQQEQQP
     QQSLSSGLQS NNEVVCLSDD E
//
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