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Database: UniProt
Entry: Q9MZ41
LinkDB: Q9MZ41
Original site: Q9MZ41 
ID   KLRD1_PANTR             Reviewed;         179 AA.
AC   Q9MZ41;
DT   15-MAY-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   10-APR-2019, entry version 117.
DE   RecName: Full=Natural killer cells antigen CD94;
DE   AltName: Full=Killer cell lectin-like receptor subfamily D member 1;
DE   AltName: Full=NK cell receptor;
DE   AltName: CD_antigen=CD94;
GN   Name=KLRD1; Synonyms=CD94;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=10894168; DOI=10.1016/S1074-7613(00)80219-8;
RA   Khakoo S.I., Rajalingam R., Shum B.P., Weidenbach K., Flodin L.,
RA   Muir D.G., Canavez F., Cooper S.L., Valiante N.M., Lanier L.L.,
RA   Parham P.;
RT   "Rapid evolution of NK cell receptor systems demonstrated by
RT   comparison of chimpanzees and humans.";
RL   Immunity 12:687-698(2000).
RN   [2]
RP   ALTERNATIVE SPLICING.
RX   PubMed=11751968; DOI=10.4049/jimmunol.168.1.240;
RA   Shum B.P., Flodin L.R., Muir D.G., Rajalingam R., Khakoo S.I.,
RA   Cleland S., Guethlein L.A., Uhrberg M., Parham P.;
RT   "Conservation and variation in human and common chimpanzee CD94 and
RT   NKG2 genes.";
RL   J. Immunol. 168:240-252(2002).
CC   -!- FUNCTION: Plays a role as a receptor for the recognition of MHC
CC       class I HLA-E molecules by NK cells and some cytotoxic T-cells.
CC       {ECO:0000250|UniProtKB:Q13241}.
CC   -!- SUBUNIT: Can form disulfide-bonded heterodimer with NKG2 family
CC       members (By similarity). Interacts with the adapter protein
CC       TYROBP/DAP12; the interaction leads to natural killer cell
CC       activation (By similarity). {ECO:0000250|UniProtKB:Q13241}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass
CC       type II membrane protein {ECO:0000255}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC         Comment=Additional isoforms seem to exist.;
CC       Name=1; Synonyms=CD94-A;
CC         IsoId=Q9MZ41-1; Sequence=Displayed;
CC       Name=2; Synonyms=CD94-B;
CC         IsoId=Q9MZ41-2; Sequence=VSP_003056;
CC   -!- TISSUE SPECIFICITY: Natural killer cells.
DR   EMBL; AF259054; AAF86964.1; -; mRNA.
DR   RefSeq; NP_001009062.1; NM_001009062.1. [Q9MZ41-1]
DR   RefSeq; XP_009423053.1; XM_009424778.2. [Q9MZ41-1]
DR   RefSeq; XP_016778010.1; XM_016922521.1. [Q9MZ41-1]
DR   UniGene; Ptr.6293; -.
DR   ProteinModelPortal; Q9MZ41; -.
DR   SMR; Q9MZ41; -.
DR   STRING; 9598.ENSPTRP00000057110; -.
DR   PaxDb; Q9MZ41; -.
DR   Ensembl; ENSPTRT00000065546; ENSPTRP00000057110; ENSPTRG00000004671. [Q9MZ41-1]
DR   GeneID; 450156; -.
DR   KEGG; ptr:450156; -.
DR   CTD; 3824; -.
DR   VGNC; VGNC:8433; KLRD1.
DR   eggNOG; KOG4297; Eukaryota.
DR   eggNOG; ENOG410XPJ1; LUCA.
DR   GeneTree; ENSGT00940000160107; -.
DR   HOGENOM; HOG000220925; -.
DR   HOVERGEN; HBG099800; -.
DR   InParanoid; Q9MZ41; -.
DR   KO; K06516; -.
DR   OMA; YSEEHHA; -.
DR   OrthoDB; 1389571at2759; -.
DR   TreeFam; TF336674; -.
DR   Proteomes; UP000002277; Chromosome 12.
DR   Bgee; ENSPTRG00000004671; Expressed in 6 organ(s), highest expression level in liver.
DR   GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   GO; GO:0023024; F:MHC class I protein complex binding; IEA:Ensembl.
DR   GO; GO:0023030; F:MHC class Ib protein binding, via antigen binding groove; IEA:Ensembl.
DR   GO; GO:1990405; F:protein antigen binding; IEA:Ensembl.
DR   GO; GO:0002228; P:natural killer cell mediated immunity; IEA:Ensembl.
DR   CDD; cd03593; CLECT_NK_receptors_like; 1.
DR   Gene3D; 3.10.100.10; -; 1.
DR   InterPro; IPR001304; C-type_lectin-like.
DR   InterPro; IPR016186; C-type_lectin-like/link_sf.
DR   InterPro; IPR016187; CTDL_fold.
DR   InterPro; IPR033992; NKR-like_CTLD.
DR   Pfam; PF00059; Lectin_C; 1.
DR   SMART; SM00034; CLECT; 1.
DR   SUPFAM; SSF56436; SSF56436; 1.
DR   PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cell membrane; Complete proteome;
KW   Disulfide bond; Glycoprotein; Lectin; Membrane; Receptor;
KW   Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN         1    179       Natural killer cells antigen CD94.
FT                                /FTId=PRO_0000046589.
FT   TOPO_DOM      1     10       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     11     31       Helical; Signal-anchor for type II
FT                                membrane protein. {ECO:0000255}.
FT   TOPO_DOM     32    179       Extracellular. {ECO:0000255}.
FT   DOMAIN       68    175       C-type lectin. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00040}.
FT   CARBOHYD     83     83       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    132    132       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   DISULFID     58     70       {ECO:0000255|PROSITE-ProRule:PRU00040}.
FT   DISULFID     59     59       Interchain (with C-116 in NGK2A).
FT                                {ECO:0000255|PROSITE-ProRule:PRU00040}.
FT   DISULFID     61     72       {ECO:0000255|PROSITE-ProRule:PRU00040}.
FT   DISULFID     89    174       {ECO:0000255|PROSITE-ProRule:PRU00040}.
FT   DISULFID    152    166       {ECO:0000255|PROSITE-ProRule:PRU00040}.
FT   VAR_SEQ     105    105       L -> LQ (in isoform 2). {ECO:0000305}.
FT                                /FTId=VSP_003056.
SQ   SEQUENCE   179 AA;  20493 MW;  7244D99E8D9587E7 CRC64;
     MAVFKTTLWR LISGTLGIIC LSLMATLGIL LKNSFTKLSI EPAFTPGPNI ELQKDSDCCS
     CQEKWVGYRC NCYFISSEQK TWNESRHLCA SQKSSLLQLQ NTDELDFMSS SQQFYWIGLS
     YSEEHTAWLW ENGSALSQYL FPSFETFNPK NCIAYNPNGN ALDESCEDKN RYICKQQLI
//
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